Prostate Cancers and Mimics - Diagnosis

This video presents ten cases demonstrating the histopathological differentiation between prostate cancer and its mimics, including basal cell hyperplasia (primitive appearance with thick basal layer and cribriform pattern), adenoid cystic carcinoma (variant of basal cell carcinoma with punched-out lumens and perineural invasion), cribriform hyperplasia (uniform cells with sieve-like pattern lacking nuclear atypia), invasive ductal/endometrioid adenocarcinoma (papillary/cribriform pattern with pleomorphic nuclei), rectal adenocarcinoma (CDX2 positive, PSA negative), seminal vesicle tissue (golden brown lipofuscin pigment), nephrogenic metaplasia (Pax-8 positive, PSA negative), sclerosing adenosis (benign proliferative lesion with focal PSA positivity), Cowper glands (clear cytoplasm, small regular nuclei), and benign atypical leiomyoma (nuclear tibial pattern without necrosis or mitotic activity).