Gene Therapy Without a Virus — Using Ultrasound to Deliver DNA

Added: 2026-05-16

[00:00:00]We don't need a viral vector, we don't need an LNP, we can deliver the entire thing using a microbubble specifically to where you need it to go just by applying an ultrasound at that specific spot in your body. So, basically what you do is you inject the patient with two things at once, the genetic payload and suspension of microbubbles. The microbubbles are tiny gas-filled spheres roughly the size of a red blood cell with a lipid or protein shell, okay?

[00:00:22]They circulate harmlessly throughout your bloodstream until they reach the target tissue. When you point a focused ultrasound probe at the tissue you want to treat, the ultrasound waves pass through the skin and bone without depositing meaningful energy. But when they hit the microbubbles in the target tissue, the bubbles start to oscillate.

[00:00:37]And at the right frequency and pressure, the oscillation becomes violent. The pores and the gaps reseal within minutes, the bubbles dissolve, [music] the payload is inside of the target cells. And on top of that, since it's a literal bubble, [music] there's no immune profile at all for your body to recognize and attack next time, so it's very redosable.