Are GLP-1 Users ADDICTED to Tirzepatide? Hot Take! Honest Truth!

Added: 2026-05-10

[00:00:00]Hello and welcome to the downsize. This is our weekly weighin from Time Square, New York City. It's April. No, it's May.

[00:00:10]It's going to be May. May the 8th, 2026.

[00:00:15]And welcome to the downsides. This is a channel where we talk about weight loss with GLP-1 medications. GLP-1 medications are those things like the new foundo, the new Waggoi pill, Zepbound, Ompic, WGOI, I forgot one, Marjaro, uh, Trezeptide, Simaglutide, and everything else that's in the pipeline that's coming soon to a pharmacy near you. My name's Lorraine Durham, and I've lost over 50 pounds on a GLP-1 medication. I am here with my husband, >> Christopher Durham, and I've lost 100 pounds on a GLP-1. So, >> yep.

[00:00:50]>> Yep.

[00:00:51]>> So, you you may be wondering why are we in New York City? We are on the steps in the middle of Time Square at the very top >> the very top of the steps in in the middle of Time Square. So, if if you get a little traffic noise or noise, I hope you hang with us. That's why we're holding our microphones very close to get the least amount of interference on the microphones.

[00:01:18]>> Be careful. Yeah.

[00:01:20]>> So, as always, we're not doctors.

[00:01:21]Lorine's not a doctor. I'm not a doctor.

[00:01:23]If you need help with your weight loss journey, please talk to your doctor and get help the help that you need. And please, if you haven't already, take a moment to like and subscribe. We appreciate your support. And it tells YouTube that, you know, these videos are cool and other people should see them.

[00:01:38]>> All right.

[00:01:38]>> These videos are cool.

[00:01:39]>> Dang, >> other people should see them. You should really like and subscribe. Um, all right. So, what are we doing here, Christopher? Why are we in New York City today? Oh, well, for those of you who know, we have become full-time YouTubers. Well, this is not related to that. Essentially, there's still a small piece of our business that was honestly quite profitable that we still do. And we were here in the city to do a event on Time Square and Broadway uh and give out our package design awards competition called the Vertex Awards.

[00:02:09]And we'll actually be in Amsterdam next week doing the same thing. So, that takes couple months a year. And then we're YouTubing again.

[00:02:17]>> Then we're back to the But we're still committed to our daily YouTube video adventure. As Christopher told me this morning when we were lying in bed, he said, "Get up. We need to do the weigh-in." I was like, "All right."

[00:02:31]So, yeah. So, we're we're here in New York City. And you know, we got here yesterday and we're walking around and we're the billboard in Time Square, the main billboard right under where the ball drops. We looked up and what did we see? An ad.

[00:02:45]an ad for the new foundo pill. That's the new uh GLP-1 weight loss pill from Eli Liy. They have done very little advertising up to this point. April 1st, it got uh approved by the FDA. So, it's just now starting to get out intoarmacies and being able to be prescribed and etc. But a big big billboard in Times Square was dedicated to it. So, I was like, "Ah, look at Yeah, I'd like Christopher take my picture, but I think we got the picture of the billboard, but not of me pointing to the billboard, but that was cool to see right in the middle of uh Time Square.

[00:03:19]>> Yep. So, typically we would give you our weights on this thing and talk about all of that. And we'll give you a little bit about I didn't bring the scale. We do have a travel scale. I did not bring it for this one. So, >> well, you know, when I I guess we came Today's Friday, we got here Thursday. I did weigh uh on Wednesday and my weight was 146. So I started at 193 lbs. I got down as low as 138 pounds. Now I've been hanging out at about 146 for the past I don't know uh forever. We started this journey on September 29th of 2023 and uh I've been in maintenance now for about two years. So I lost at about a rate of an average weight of an average rate of 1.58 uh pounds per week. So you know we always want to tell people these this this is not quick weight loss, right? This is just consistent normally steady weight loss and the average is between a half a pound a week up to two pounds per week or about 1% of your body weight a week. So if you weigh 300 lb maybe you can lose three pounds a week.

[00:04:28]if you lose if you're 200 pounds, that's two pounds a week and etc. So, um just something to keep in mind as we as we go through this. But usually on this weekly weighin, we do give you our weights for what it's worth. But I'm 5'5, I'm 57, mom of three kids, ages 28, 21, and 19.

[00:04:47]>> So, I'm 57 years old. We started at the same time, and I've lost right at 100 pounds, depending on what day it is. Uh I'm on a 15 milligram dose. I've been now for more than a year. It works well for me. Sun's getting bright right here.

[00:05:03]There's garbage trucks going by. And we just keep rolling on. So I I weighed Thursday before we let got on the plane and I was at exactly 187 even. My center weight's 185 that I'm that I'm shooting for. So up or down a couple of pounds.

[00:05:19]It's been up upper a couple of pounds here since the cruise a few weeks ago, but honestly, it's fine. I'm not I'm not worried about it.

[00:05:28]>> No. And I mean it's it's so interesting to go as we as we travel, as we live our lives now. This has just become part of our lifestyle, right? So we still take our weekly shot. I'm currently doing a uh 10.0 milligram dose of compound nutreptide that I get from Mochi Health.

[00:05:45]And you know, I was on a 7.5 milligram dose for well over a year. And then after we came back from our cruise and I was up about four pounds, I just decided I need a little bit more help. So I bumped that up a little bit. So um but yeah, you know, the the dose that you take uh is the is not it's not important, you know, compared to other the dose that other people take, right?

[00:06:09]you need to find the dose that works for you along with your doctor uh to to get your best, you know, effects for in terms of weight loss and then in terms of maintenance once you reach your goal weight.

[00:06:21]>> So that's that piece of it is obviously we're we actually will actually only be in New York City a couple of days. We actually come back home to Charlotte, North Carolina tomorrow >> and we'll be live again on Tuesday and Wednesday. So the club down the club downsized is live on Tuesday.

[00:06:37]Lorraine's having a colonoscopy on Wednesday. So, we may move that one depending on how Lorraine feels. That might become a Thursday live.

[00:06:46]>> We'll see how it goes.

[00:06:47]>> We'll we'll see how it goes. But yeah, this is your You have to do them every year now, right?

[00:06:52]>> I do have to do a yearly colonoscopy.

[00:06:54]They've found things that were not good in there. So, they I just have to be yearly monitored at this point, which is fine. My grandmother died of colon cancer at age 80. So, it's just something in my history and something that I need to be aware of. And I think honestly, I think my whole struggle with constipation is kind of it's it's all related, right? So, it's important when you get to this age to stay on top of your yearly in-person doctor exams, get your blood work done, get your mammograms, get your colonoscopies, all those tests as we age. They're very important. Oh, and I got my mammogram results back and they're good.

[00:07:31]in case you wanted to know.

[00:07:33]>> There you go. We learn something new every day, don't we?

[00:07:36]>> Yeah. I don't think I told you that.

[00:07:37]>> No, you did not. I assume you would have told me if it was if it was not good.

[00:07:40]So, >> it's just really important to get those things done.

[00:07:43]>> Yep. All right. You can see we are in New York City. The later it gets, the more people get out here because this is the center of the world right now. All right. Let's take some questions.

[00:07:53]>> Let's take some questions.

[00:07:54]>> Our first question comes from Elaine Edwards, 2530, who says, "Why is compounding so important to you, Lorraine? I'm confused. Do you not want to use a quick pen or are pens more expensive in the states than compounding? Can you clarify this up here in Canada? Compounding GOP ones is not allowed and we all use quick bins.

[00:08:11]>> I guess the first part of that compounding is important to me because I've lost all my weight on compounded medication. So I've taken all my shots except one have been compounded mostly from Mochi Health. We don't we're not covered with insurance for weight loss medications. So we're paying everything completely out of pocket and the lowest cost option for us has been compounded. So Mochi is $199 a month for compound plus a $79 a month membership fee which covers your doctor's visits.

[00:08:44]So that's $278 a month and that's for any dose, right? So he's on a 15 milligram dose. I'm currently taking >> as close as you get. I'm currently taking a 10 milligram dose and it's just uh you know with the Lily direct and other you know the the vials the quick the higher the dose the higher the price so you really have to look at at all those factors right you know at some point in the future I imagine that brand names will be the same if not cheaper than compounded and when that happens we'll be the first to let you know but uh for now that's that's the best most cost effective option for us.

[00:09:24]>> Yeah. And for those of you out there who don't live in the US, compounding is a unique legal aberration of the United States. It does, however, exist in other countries. It's just called a normal pharmacy or normal chemist. And in the olden days, as they say, you'd go into a pharmacy or a chemist and they would make up a medication for you before manufacturing. And that's really what happens with GLP. once here in the US it's they're doing it more at scale now but it's there's nothing unique to it exists in every country now whether GLP1s can legally be made by them in every country is a different question so uh right now you know there's a lot of the smalleries those 503A uhies that can make personalized doses and they combined the trespatide with something else like elcartinine or nyinomide um so that's how they make it different than the brand names. Now, of course, the, you know, big pharma doesn't like that and they're trying to prevent that from happening, but so far they have not been successful in that.

[00:10:31]We use Mochi Health for our compound. If you'd like to use Mochi Health and get started, there's a link uh in the comments. If you click it, I uh get the the direct credit or if not, there's my code in the comments also. You can use my code or my link and save $40 on your first uh month of Trespatide. Yeah.

[00:10:52]>> Or some glutide if you'd rather have some glutide.

[00:10:55]>> Next question is from Jacqueline Walter 6811 who says six months on doctor's weight loss program and three months on WGO. A total of three pounds lost.

[00:11:04]>> Oh, so $150 a pound since I I think that is more due to increased walking. Any suggestion what medication people might use if WGOI has not worked? need to lose 40 pounds. No co-orbidities.

[00:11:17]>> Well, so here's the thing. I if you >> talk to your doctor because your doctor should know there are other options.

[00:11:24]Obviously, we're not doctors. We can't make prescribing recommendations, but the options that exist today are semiglutide or tzepide. So, semiglutide is oyic. Sounds like you've been on that and >> doesn't sound like it works too great for you. The other option is tzepide which is zeppelaro.

[00:11:44]>> Okay. Talk to your doctor. I mean there are different cost considerations, health considerations. You say you don't have any coorbidities. So you know but that that's the other option and many people do well. That's what we've lost our weight on.

[00:11:57]>> Yeah. So you know you do have to look at this as a long-term play for weight loss too. So you know you you need to look at it. You know, we know people who have lost very little weight on these medications until they get up to the higher doses. We know people who have done very well on the lower doses. How your body reacts is just individual to you. So, it's you can either stick it out and try to get up to that top dose and see what happens or switch to a different medication. And to be clear, because we don't know anything about your health, your titration and all that, if you did not consistently titrate up under a doctor's supervision and you are not losing weight, you're not helping yourself, >> right? I mean that, you know, these medications were the clinical trials were studied, you know, for Zepbound with a titration schedule of every four weeks. they move the the patients in the study up in the dose >> endompic >> right and so that's what's recommended by the drug manufacturers now some people stay on a dose longer than that because if a dose is working if you're losing one to two pounds a week stay on the dose right no need >> if it's not working don't hang out on a dose >> yeah maybe you just need more medication and there's nothing wrong with that I think people get caught up sometimes and say oh well I just need a I just need a small dose I just need a little bit I'm not, you know, I'm not that overweight or I'm not, you know, it it doesn't matter. It it it truly does not matter your dose and it it's just dependent upon the person.

[00:13:32]>> You want to take this one?

[00:13:33]>> If I can read, it's very bright out here.

[00:13:35]>> This is from Serena Dodd. Hi, is it possible for 1 milligram of Ampic to quiet food noise better than 15 milligrams of Mangaro?

[00:13:45]>> Maybe. I've been on Mjaro for nine months and the food noise has never really gone away. This week I tried my husband's Ozepic as I couldn't get my shot and woke up the next day with no food noise for the first time. I am two days in and no side effects and no food noise. Isn't Mandaro supposed to be better? You know, that's one of those weird things where we say everybody is different, right? And you may have unlocked what is the right thing for you. Now, you know, please don't take someone else's medication because you're really not supposed to do that. But, you know, ask your doctor maybe to switch you over. that one works better for you then it works better for you and mangaro has been proven more effective but they're both very effective for weight loss >> and semiglutide I mean has been compared more to a a hammer that just is very blunt and can stop things so it may have worked now what I would tell you is you have a sample of one one person one week so it might have just been that week your body decide to do what it wanted to do you could try again and see what happens >> try Yeah, it'd be worth a shot. But >> that that may not you may not get see that happen again week after week.

[00:14:54]>> So, but I I would I would say that's I I would definitely go after that.

[00:14:59]>> Yep. I >> But I'm not a doctor.

[00:15:02]>> Next question is from Mand P655 who says, "Hi there. Do you all think a GLP1 will be developed for women who are in maintenance but also TTC?"

[00:15:12]>> What's TTC?

[00:15:13]>> I had to look up TTC. I'm assuming what I looked up is correct.

[00:15:17]>> If it's not, >> total >> No, it's trying to conceive.

[00:15:21]>> Oh, >> if if it's not trying to conceive, the answer we're about to give you is completely wrong. So, tell us and we'll try again. Um, what I would tell you is all of the clinical research that has been done on these medications essentially says there is no real difference between how it reacts in men and women and between any age group or any ethnicity.

[00:15:44]Except for the newest research, and I'll have it in the news this week, actually says women lose a little more weight on these medications than men do.

[00:15:51]>> Not a lot, but a little bit more. women.

[00:15:54]>> Now, the trying to conceive part is a whole separate conversation.

[00:15:58]>> Yeah.

[00:15:59]>> I do not believe there is any medication in development or in trials that's specifically focused on that. And the current recommendation is that you stop taking these medications if you're trying to conceive medically. Not my recommendation. There are medical groups that have >> Right. Um, you know, it's and that kind of like kind of sucks, right? Because you know I I think about my uh my hairdresser. She I first told her about our trespide use. She got on it, her mom got on it. She uh decided she wanted to try for a second child. So she stopped taking it, you know, gained weight, gained pregnancy weight, and then as soon as uh her doctor cleared her, I think maybe six weeks out, she went back on it. and she really hated to have to go off of it, but you know, that's the current recommendation. In the future, uh, who knows? I mean, there's they're they're studying it. I I saw one uh doctor talking about its effects on breast milk and things like that. So, you know, we look forward to hearing more studies on that.

[00:17:07]>> Yeah.

[00:17:09]Next question is from Elrisa07 who says, "I" and this is on one of our Medicare videos, who says, "I can't be on Medicare for at least 20 years. So, what about us that aren't eligible for Medicare yet?"

[00:17:20]>> Yeah, what about us?

[00:17:21]>> I get it. I'm 57 years old. I'm not eligible for Medicare either. And you know, everybody always wants to know what's in it for them. This is a longer term play and it's a play that I promise if it actually works out will help.

[00:17:35]>> It'll trickle down.

[00:17:36]>> It will trickle down. And honestly, we celebrate every time somebody can get affordable access to these medications, whether it's me or not. I don't I don't have to gain from it. So, I don't look at it that way. But I do wonder when when can we, you know, get $50 meds ourselves.

[00:17:53]The theory here, and it's you've seen we've seen it over and over again with other medications, is when Medicare and the government accepts it into coverage, commercial insurance, that insurance that your employer may have for you typically follows Medicare. Now, it may be a year or something after that, but they typically follow Medicare. If Medicare doesn't take it, your insurance is never going to, >> right? So, it's it's a good thing to for Medicare to cover it. It'll help everybody eventually. Is it gonna help you in the next six months? Probably not, but maybe next year or in the next five years, certainly. So, >> so it's coming, but be patient. And like I say, we celebrate every time somebody gives access to this.

[00:18:34]>> Next question.

[00:18:35]>> Oh, one moment.

[00:18:37]>> Uh, this is from ES7140.

[00:18:40]From what I'm understanding, in your opinion, the new foundo pill is more used for maintenance. I don't think we've said that, but whereas the Zepbound shot is better for losing and/or maintenance. We we haven't said that. Some people were maybe thinking that and we were maybe even thinking that it's still not the cheapest option and the clinical trial results of foundo are less weight loss than Zepbound. So, but if you'd like a once daily pill that you can take any time of day and lose 12% of your body weight starting atund what is it $199 a month? I mean, >> yeah, if I >> I think it could well be used for maintenance and it may be worth people trying if it fits better into your budget and they did research on it and it and it did fine for maintenance.

[00:19:31]Right now, what we're seeing with all of the numbers is for both oral WGO and foundo, this is really about new starts.

[00:19:39]People who have never taken GLP1s, like 40% of these prescriptions are going to brand new people because they walk into their doctor and the doctor says, "Hey, I've got this pill. You can take it once a day. It's 149 bucks."

[00:19:52]>> Yeah.

[00:19:54]>> And all of a sudden, they can afford it.

[00:19:56]And they're not afraid of a shot. And it opens for everything. And it opens access, right? It's just not scary. I think that's where the big numbers are going to come from.

[00:20:05]>> And honestly, I don't worry about clinical trial numbers. That doesn't mean anything to me because nobody's the average.

[00:20:11]>> We've we've both >> I lost 38% on on >> Zepbound and the clinical trial says you're only supposed to do 18. So, >> yeah, >> you know, >> uh yeah, you know, your your results may vary for sure, but we've had so many people that have told us, "Oh, I'm afraid of needles." Oh, you know, maybe I don't a shot that seems so involved and complicated. So, you know, this pill could be a real gamecher for a lot of people.

[00:20:40]>> So, next question is from Rob Taylor who asked a question on Lorraine's interview with Dr. Michelle Cardell with Kyler Therapeutics, and he says, "I enjoy your channel, but this was such a huge missed opportunity. What was the study design?

[00:20:54]Did they test a hypothesis or just summarize results? How long was the survey? What were some of the questions?

[00:20:59]How were the results summarized?

[00:21:00]>> Is this the food noise?

[00:21:01]>> Yeah, this is the food noise. Did any of the study participants or all of them use a GLP1? How large and long a study?

[00:21:07]>> How the food noise correlate to the weight loss? Okay. He says, "I'd also love to know what her current employer does. If I had to guess, she has a beard for a massive telealth company that >> just does GLP ones." I'm not saying her credentials aren't valid, but I'm saying she wasn't on your show until her employer reached out and pitched her to your show. Am I correct? No, you're not.

[00:21:26]Uh, keep up. I found her. Keep up the good work, but get better. Well, Rob, >> thanks for the feedback. So, if you go back and listen to that, she actually talked about that research wasn't published yet. So, that was really just a preview. Now, I actually have the entire set of researchers that are going to come on and do a panel in the next couple of weeks and give us all of that detail. So, hang around, watch the whole video because we're always better. I promise. Well, as far as her employer shield for a tele health, that is not at all what she is. She works for a company called Chyera Therapeutics.

[00:22:00]>> They just went public, >> which just went public. They're a major drug manufacturer. They have a portfolio of GLP1s that is in development that looks remarkably similar to Eli Liy's and they're coming after Eli Liy's market. They did not reach out to us. I reached out to her. Honestly, doctors never reach out to us. Dietitians never reach out to us. If you see a professional, I had to go find one. If you're a doctor or dietitian and you want to come on and be interviewed on the downsized, uh, you know, please go to our website at the downsize.org and and you can contact us through that.

[00:22:30]We'd love to talk with you. You know, a lot of people think, oh, you know, the downsize, they know everybody. Everybody comes to them. Not true. So, you know, please, if you uh have somebody you want to send our way or if it's you yourself, like we'd love to talk with you.

[00:22:44]>> But yeah, Michelle Cardell, go look her up. She has published all kinds of stuff. We publish medical research. You always have to reveal any sort of conflicts you have. She's legit. I promise.

[00:22:55]>> Yeah. And she knows Dr. Anya. She's she she was going to connect us with Dr. Ana.

[00:23:00]>> Actually, she connected us. She already connected me to to Dr. Fatima Stanford Cody, too. So, we're working on her interview with her.

[00:23:07]>> Yeah.

[00:23:08]>> Uh, next question is an easy one for you.

[00:23:10]>> Thanks for the thanks for the softball.

[00:23:12]This is from Joe Rosal. How does Trespatide compare to Zepbound? Um, they're the same. Uh, Zepbound's active ingredient is Tracepatide. Compounded Trazeptide is Tracepide. So, Tracepide equals Trazepide. Now, a lot of people want to know is the branded Zepbound work better than the compounded compounded Treseptide. Christopher, you've taken both. What do you think?

[00:23:36]>> As a sample of one, I can tell you I have taken compound Trapide from seven different compoundingies.

[00:23:42]Branded Zeppbound and branded Mangaro, all same active ingredient, Trazepide. I could never tell a difference. I lost the same amount of weight. If I had side effects, they were the same side effects. It all work the same for me.

[00:23:54]>> All right, next question is from Deborah Deus, who says, "I've wondered about the Hume scale. Do you think it's a good deal?"

[00:24:03]Um, yes. The next question.

[00:24:08]Yeah, we we are sponsored by the Hume Body Pod. We have one. We've used one. I recently had a mishap with mine and I and they had to send me another one.

[00:24:19]>> She broke it.

[00:24:20]>> I I It was It wasn't the scale's fault.

[00:24:22]It was my fault. I dropped the handle.

[00:24:23]Don't drop the handle. It does retract back, but the little plate came off. So, uh yeah, I do think it's a good deal.

[00:24:30]And the reason why I say that is because it gives you a very accurate measure of your other measures beside just your weight, your body fat, your muscle mass, your body water percent, all these different metrics. It's like you can even see the metrics from right arm, left arm, right leg, left leg to I mean at at some point maybe it's information that's just nice to know, but you know what do you really do with it? But what I really like to see is that muscle mass number go up, that fat percent number go down. And the fat percent number on our old scale that didn't have the handle that wasn't a human body pod was not accurate. We did a DEXA scan maybe six months ago. We need to do another one.

[00:25:12]We did a de we did a DEXA scan and then we came home and weighed on our body pod and the results were within 1%. Now the DEXA scan is is the gold standard, right? It uses thousands of dollars of equipment and it it you know it's it's it's the best. So for this home device that sits in my bathroom and I can weigh on it every day if I want and get an accurate reading as a DEXA scale a DEXA scan is fantastic and definitely worth the price. So, if you'd like to see it, we actually did a video comparing the DEXA scan results to the results on the human body pod to a traditional scale.

[00:25:49]>> Yeah.

[00:25:50]>> All we weighed all in the same day. So, the numbers now we're samples of two.

[00:25:54]So, you take it for what it's worth, but we show you all the data. And yes, indeed. Actually, I think mine was a little less than 1% difference. So, >> yeah. So, you can use our code the downsized for an extra savings on the Hume body pod. Our link in our code or in the description of this video. Yeah, next question is from William Herren who says, "Do you think you both are addicted to turppetide?" So, I answered William in detail on this one, >> but I wanted to talk about it here as well.

[00:26:21]I don't know whether this is a legitimate question or you're trolling.

[00:26:24]I'll assume it's a legitimate question.

[00:26:27]Um, so Trozeptide, cotide, GLP1s are drugs that have been created and they essentially mimic a natural natural hormones in your body. There's nothing addictive about them. So medically, scientifically, these are not addictive substances. So, are we addicted to them?

[00:26:45]No. That's that's not even an accurate statement. They're not they're not opioids. They don't act on the same that same pleasure center of the brain. Uh and these are medical treatments for the disease of obesity, right? It's not a party drug. It's not it's not something else. These are prescription drugs and they are used, think of them more like blood pressure medication, >> cholesterol, >> cholesterol medication, insulin for diabetes. They're not addictive. So, the notion that that that we would be addicted to them.

[00:27:20]>> I It's just I don't know.

[00:27:22]>> I just noticed there's Eva Noazada over there on the Great Gatsby poster. She used to live in our She used to live in our neighborhood.

[00:27:29]>> Uh there's a lot for Lorraine to get distracted by. A lot going on here in Times Square. I've got a Chicago ad over here. I've got Netflix. I've got Pandora. I've got Olivia Rodrigo staring at me. I've got all kinds of things. I love Times Square.

[00:27:44]>> The Star Wars Mandalorian and Grou. We got to see that. All right. Now, back to our regularly scheduled programming.

[00:27:51]>> Yeah.

[00:27:52]>> So, no, we're not addicted. And honestly, medically, that's not the way these medications were.

[00:27:57]>> I'm addicted to being 50 pounds down and being at my goal weight.

[00:28:00]>> Sure. Okay, Ann Quitman, hey Ann, she's a long time watcher has a question. Rain and Christopher, during your weight loss journey before maintenance, did you have a month where you actually gained weight?

[00:28:13]>> A whole month?

[00:28:14]>> I don't know. If yes, was it easier for you to deal with it better on the medication compared to how you might have dealt with it pre-trazeptide? Yes, absolutely. I asked because the answer for me is yes. Yeah, you know, this this weight loss isn't linear, right? You're going to have some bumps in the road.

[00:28:30]life happens. You know, this is a longtermed uh medication, right? So, if you have a month where your weight goes up or you have something an event that happens in your life, maybe you have to go off for a surgery or something happens with your family, you're not able to something, you know, this is life, right? So, the, you know, the point is just get back to your regularly scheduled shot, get back on your regularly scheduled stuff and look at this as a long-term play, right?

[00:28:59]There have been definitely have been weeks when our weights have gone up. Um, and it and it it does bother me. It still bothers me to see that number on the scale go up. I, you know, I've been weighing myself since I was eight years old. It's not going to just magically like be okay now in my brain. So, uh, but it's okay. You know, this is a long look at your trend line. It should be going down in the weight department.

[00:29:25]And, uh, you know, we're just going to keep going. We're not going to stop taking this medication. We're not we're not stopping it. We're not, you know.

[00:29:33]So, um I guess that's that's my thought.

[00:29:37]>> Yeah, I'm with you on that one. Next question is from Connie Garvey, who says, "I must use a power wheelchair to get around. How can I exercise effectively? I'm taking Mangaro to help lose visceral fat, which is causing me to need to use oxygen 24/7."

[00:29:53]>> Wow.

[00:29:53]>> This is where we say we're not doctors again. We also say we're not physical therapists, trainers.

[00:30:00]>> I I don't know.

[00:30:01]>> Yeah, this is a hard one and I wish I could help you with this. What I would tell you is please talk to your doctor and get some other help with it.

[00:30:07]Probably a physical therapist could help you. There's generally some body weight sort of exercises that even if you can stand up and down like our friend Jamie Szler said when he was 500 plus pounds his exercise to begin with was st he stood up during every TV commercial >> cuz he was picking up 500 lb and that's weightbearing exercise right >> so you have to figure out those small things to do for you because as you say you you know you got to breathe you gota >> and I think another important thing to realize is exercise is important. I love exercise. I'm a big fan of exercise. I work out four or five times a week.

[00:30:45]Although not this week cuz, well, yesterday we walked about 10,000 steps.

[00:30:49]But anyway, I'm a big fan, right? But let me just tell you, you do not have to exercise to lose weight on these medications. It's good for you. It will help your progress, but it is not 100% required. So, if you physically are unable to exercise, but you're at least taking your shot, I mean, if that's all you can do, start where you are, right?

[00:31:11]Don't don't make yourself crazy and think you have to do all the things.

[00:31:16]Just focus on what you can do.

[00:31:19]>> Yep. And eat well. Make sure you're getting good nutrition, >> right? The food is the most important thing for weight loss. What you're eating, that's the number one most important thing.

[00:31:28]>> The number one is the is your medication, but number two is food.

[00:31:31]Well, yeah, that that >> next question was on your interview with Susie.

[00:31:36]>> Susie, shout out to Susie in New York City. She's she's out of town or we would have met up with her this week.

[00:31:42]>> Uh who says, "Thanks for the convo on maintenance. I've been on Mjo for a year now and nearing my goal weight. My doctor is talking about gradually tapering my dose. I'm on 10 right now, down to 2.5 for maintenance. Have you heard of anyone being successful tapering down? When I look online, I can see testimonies of people staying on the same dose and spreading out the time between injections. I appreciate any insight you might have.

[00:32:06]>> Yeah. You know, I I hear this all the time about doctors telling their patients, "Oh, you know, once you hit your goal weight, we're going to taper you down and then you're going to stop taking it." I am not a doctor. Okay. Um and I did I tapered down. I would ended on 12.5. I dropped to 10. I dropped to 7.5. I dropped to five. that was too low. I had too much food noise. I went back up to 7.5 and stayed there for over a year and just recently went up to 10.

[00:32:34]Um, you have to figure out what works best for you. I was dropping down a dose really in a thought that maybe I could save some money if I was on a lower dose if if you know I ever had to switch to branded. And, you know, now I I don't think that way, but the dose that I'm on is working for me. Now, Christopher never went off a 15 milligram dose >> and don't plan on it.

[00:32:58]>> So, the doctors that we've talked to, you know, they kind of have both theories. Um, but you know, I'm also on LinkedIn. You can follow me, Lorraine Durham and Christopher Durham. We're on LinkedIn, which is a business platform.

[00:33:12]And a lot of obesity doctors are also on that platform. And Dr. Robert Kushner is a big obesity uh doctor, care advocate.

[00:33:22]He does a lot of work with the O obesity action coalition and uh just the other day I saw him post an article he had written about, you know, how these are long-term medications and doctors need to tell patients that, you know, maybe they don't come off of these medications. And I I put a note on there. I'm like, "Thank you, Dr. Kushner, for promoting this among physicians because a lot of doctors have not gotten this message. they just don't have the the training or the understanding of how these obesity medications work.

[00:33:57]>> And what I would tell you is advocate for yourself. So at the end of the day, it doesn't really matter which dose you're on unless there's a pricing consideration. The right dose for you is the right dose that works.

[00:34:08]>> Yeah.

[00:34:08]>> If 2.5 works, that's great.

[00:34:11]>> Yeah. Like Susie 2.5, >> that's great. But if you need five, 7.5, what whatever you need, it doesn't there's no moral implication. There are pricing implications for some doses, but >> so but you have to be an advocate for yourself with your doctor. And honestly, the best doctors want to have the conversation and work with you to get to the right place.

[00:34:31]>> Yeah.

[00:34:32]>> It shouldn't be just this is what you get. It should be let's talk about it.

[00:34:36]How are your feelings? What are your side effects? You know, and it's it's a conversation. Well, you know, obesity medicine certified doctors are a different breed of doctors. And if you're lucky enough to work with one of those, uh, it's a very different experience from what we understand because we've only listened to those doctors like speak at, uh, conferences and things like that. But patients, I know uh one of our watchers, Lisa, recently went and met with an obesity medicine doctor and she described the experience as so understanding and caring and knowledgeable and it was just, you know, it wasn't just your doctor uh you know, you sitting on the exam table and your doctor saying, "Well, you just need to diet and exercise." You know, that and that's what uh you know, I got for years.

[00:35:27]Final question for today is from Pony Girl 5716.

[00:35:31]>> Like Pony Boy, stay golden. Yeah, stay gold.

[00:35:33]>> Say gold. Stay gold, Pony Boy. We're outsiders this way.

[00:35:35]>> Pony Girl, I think wins for the longest com question we've ever gotten.

[00:35:40]>> Like two pages.

[00:35:41]>> That's I I think it's about a thousand words. That's fine. We appreciate all the information. I'm not going to read all of the question, but she does say, "I missed the live, but I do have a question that I'm hoping you'll be able to answer to. I'm going to jump considerably down through it."

[00:35:55]>> All right. Uh, and she says, "My main question is, I'm having a hard time understanding why so many people keep saying weight loss is not about calories in, calories out, >> but yet they are able to lose weight on GLP1. To my knowledge, it seems like what GLP1's do, they make it easier for us to eat fewer calories. They make it easier to avoid overeating. To my knowledge, and definitely, correct me if I'm wrong, it doesn't do much adapting metabolism or other magic tricks on its own. So, we burn more calories from the drug alone. Food intake intake being decreased. calories in it uh is what causes the weight loss. Correct? Um sort of is the answer.

[00:36:32]>> Can I just point her toward a book called Enough by Dr. Ana Jesterbuff and Oprah Winfrey, which really explains how in a person with obesity, calories in, calories out does not work like it does in a person without obesity. When you have obesity, your body is storing any calories you eat as fat, no matter how little calories you're eating. And so it, you know, Oprah describes a time when she was hiking six miles a day, eating 5 to 600 calories and gaining weight. Now, that's not mathematically possible in that calories in calories out model because your your body doesn't work that way.

[00:37:11]So, I would encourage you to read that book. It's available on our Amazon store or wherever you get your books.

[00:37:17]The the challenge of it is it sounds logical, >> but it's a dramatic oversimplification.

[00:37:23]So, calories in, calories out assumes that there's this little small enclosed model. I described it a couple of weeks ago as kind of like you start a fire in a little pot and you put one piece of wood in and that wood's like food and you light the fire and the fire burns the wood and that's the food being digested, right? Fuel.

[00:37:40]>> So, fuel in, calories in, calories out, they burn.

[00:37:44]>> Okay. The challenge of that is our bodies don't actually work like that.

[00:37:47]Our bodies are designed like little ecosystems and there's minerals and water and they're designed to protect themselves at all cost in that calories in calories out model.

[00:38:01]You just assume it all burns. Well, that's not what happens. What really happens is your body says, "Ah, I think I'm dying. I think there's a famine. I need to save this for later." Regardless of how many calories you ate, if you have the disease of obesity, your body is in save mode, >> it's in uh I'm going to keep you alive mode no matter what. And I >> it will store even those 500 calories and go up. I'm putting it right here.

[00:38:27]>> You know, obesity is metabolic dysfunction, right? And obesity is caused by all kinds of things. It can be caused by genetics, environment, who knows what. And really, you know, who cares? uh people, they're the worst. Uh um and and who knows what has caused your obesity. And really, it it doesn't matter, but it's metabolic dysfunction, right? And these medications help your body correct that dysfunction and get you without food noise. People are who are at their normal weight, most of them don't have food noise. 99% of them don't have food noise. They don't even know what we're talking about when we describe food noise because they've never felt it. they've never heard it and they don't understand it. So it's >> so yeah >> metabolically does it speed things up?

[00:39:16]No, it does not do that. However, it does get things in better alignment. So at the end of the day, this is really a a communication problem. It's really your body going feed me, feed me, save me, save me, save me, and it's not sending the correct signal to your brain. That stomachtobrain connection. So there's it's missing and this is evening out your metabolism and saying you're okay.

[00:39:41]Stay calm. You can digest this. This food can go away.

[00:39:46]>> You can release some of this weight now because you're not starving to death.

[00:39:49]There's no famine. There's no uh you know it's it's okay. So >> beyond that, these medications do more than just keep you from from eating, right? They also have a tremendous benefit on inflammation. Inflammation can cause you to to store weight in a different way as well. It can be water gain. It can there there's all kinds of things. And many people report early on the inflammation subsiding and losing weight just from the inflammation subsiding, right? You can feel it a lot of times in the first couple of days.

[00:40:20]>> Yeah, for sure.

[00:40:22]>> Inflammation.

[00:40:22]>> It's just not as simple as that. I wish >> Oh, there's the foundo. Did you see it?

[00:40:26]It popped up on the screen.

[00:40:29]>> All right. All right. A lot going on here in Time Square.

[00:40:31]>> So, that's it for us today. As a million people converge, hopefully you have actually been able to hear this. We'll know when the sound is back.

[00:40:38]>> Yeah.

[00:40:39]>> Um there's like a foot behind me and somebody just walked behind us. I'm like, "Okay, >> you know, I'm going to stand back here.

[00:40:47]It's all good."

[00:40:48]>> All right. That's a public space. Now, we tried to record in the in our hotel.

[00:40:53]Uh, and there's a there's a conference room and there's a concierge desk right in front of the conference room. And we said, oh, can you mind if we go in there for an hour and uh, you know, we need we need to take a conference call. And the answer was, how much would they want us to pay?

[00:41:08]>> $1,500.

[00:41:09]>> $1,500. I'm like, better Renaissance, Marriott. Okay. Anyway, that was annoying. So, that's why we're out here in Times Square, but it's been uh it's been kind of fun out here in Time Square.

[00:41:18]>> It has. If you have a question, you can leave a question for us underneath this video. Make sure you use a question mark, >> right? And maybe we'll answer your question in the next video.

[00:41:27]>> All right. We also have our downsized at sea cruise coming up June 4th through the 8th. And there are still cabins available. We'll be sailing out of Miami, Florida to Nassau, Bahamas, and uh the private island Coco K. Got about 80 people joining us if you'd like to hang out with us, watch us film some shows, do some meet and greets.

[00:41:49]Go to the beach, have dinner, the whole nine yards. Come and join us. Go to the downsize.org and you can learn all about it. Sounds good. Yeah, you can also check out our Amazon store. It's on the downsize.org.

[00:42:05]Guys, so loud behind me. Uh I've uh curated some products that I like on this GLP1 journey. We do earn a small commission off of each purchase, so we we thank you for that. It helps uh support us in our quest to be full-time >> GLP wonders YouTubers.

[00:42:22]>> Oh, well, I think we already that. So, I'm not sure why we have a quest.

[00:42:26]>> I'm still on a quest. Well, on our quest to be that What is that noise? It's so loud. There's so much going on in here.

[00:42:32]All right, we'll wrap this up.

[00:42:34]>> That's it for us this day from Times Square, New York City. My name is Christopher Durham.

[00:42:40]>> I'm Lorraine Durham.

[00:42:41]>> If you haven't already, please take a moment to like and subscribe. Been we are the downsest.