RETA Is More Powerful... But Is It Better Than Tirzepatide?

Added: 2026-06-06

[00:00:00]All right, in this video we're going to discuss really the benefits of using Retat versus Tirzepatide and the potential downsides and which is going to be the better protocol for you. Now, this is for someone that's already decided that they want to use a low-dose GLP to improve satiety, to make it easier getting lean, staying lean, and removing that mental battle with calorie adherence. That's effectively the use case in my book. So, you've decided you want to use a low-dose GLP, okay? Now, a lot of people don't need this stuff, right? If you have an easy time hitting your calories, staying satisfied, sticking to the plan, making results, amazing, okay? This is for someone that's been struggling for months, battling months, right? And they're like, "Okay." They've done the research, they're interested in doing a low-dose correctly. Okay, so what is the better protocol using Tirzepatide or Retat?

[00:00:44]Now, first I have to state my bias. I do have a clinic in the USA, the Kino Clinic, where we offer pharma-grade Tirzepatide. I do not offer Retat. There are 503A pharmacies that will compound Retat. They're not supposed to, but they're doing it. It's something I could even look at offering, okay? It's not something that's legal, but there are pharmacies that are doing it currently, okay? Now, I still choose not to. I choose to do Tirzepatide, and I'll explain why. But, for some people, Retat, if you can get access to pharma-grade Retat, it might be the move for you. So, we'll get into the benefits and downsides. Now, first sort of order of business, if you can get it pharma-grade compounded, okay, that's going to be better. There are a lot of people ordering this stuff on research sites, and there's just no guarantee you're getting correct potency or purity, and so you might get something that's weaker or stronger, and so there is risk involved with that, okay? And with 503A pharmacies, they have to follow US pharma law, so there's a lot of good stuff there, okay? So, let's get into really the benefit of using Retat.

[00:01:51]And so, the reason they created Retat, okay, there's a lot of miscommunication or or misinformation. A lot of people thought that the third agonist, right, the triple agonist, the reason they created Reda was to help protect the muscle so you hold more muscle as you get leaner. Now, this isn't true, okay?

[00:02:06]That's the glucagon mechanism. The third mechanism is glucagon. Now, glucagon is a catabolic hormone, it's a stress hormone, it raises your metabolism a little bit. And the idea is that will help with fat loss, whereas with tirzepatide, you're improving satiety, you're improving insulin sensitivity, you're better improving your ability to use glucose for energy stored in the muscle, but you're not increasing your metabolism significantly. So, with Reda, right, with the triple agonist, the glucagon can raise metabolism a little bit. Now, how much does that help? Well, in the trial data, with tirzepatide, people can lose 22% of their total body weight, and with Reda, they can lose, you know, 26 to 28%. So, an additional 15 to 20% weight loss is achieved with Reda. And that's the effect largely of the triple agonist, of glucagon, okay?

[00:03:00]So, if you want to lose weight as fast as possible, Reda will be more powerful, and that's why it was created in the phase two trials, right? In the tirzepatide trials, in the semaglutide trial, some people eventually hit a plateau. They hit a plateau before they get to their ideal BMI, and so they wanted to create a triple agonist. Now, here's where it gets interesting, okay?

[00:03:23]In the trials, they just want to see what the drugs do by themselves, okay?

[00:03:28]So, they're not telling people to do structured training programs, to hit certain calories, to hit protein, to get 10,000 steps a day. They just want to see, what do these drugs do on their own, right? Okay, so what is the downside of Reda? So, the downside of Reda is you are creating chronic activation of a stress hormone, of glucagon. This raises resting heart rate significantly. So, in the data, you can get a significant increase in resting heart rate. That's not ideal for longevity, for health, a lower resting heart rate is better. If you want to sleep better, right? A lower resting heart rate is more optimal. As well with the stress hormone, right? The chronic activation of stress hormone, you can also suppress HRV. HRV is really good for health. So, you want to have a higher HRV, okay? And so, Retatide can potentially you know, it can potentially lower that more significantly. And, right? And what people don't realize is, if you go and read the phase two trial data of Retatide, there was 37% lean body mass loss. Go Go Google this, right? Or go pull up the trial data. 37% lean body mass. With Tirzepatide, it was 25%. So, looking at that, Tirzepatide appears to be more favorable for body composition, for holding muscle, right? Holding muscle, losing fat, which is the opposite of the internet rumors, the internet kind of mess, right? So, in if you look at the phase two trial of Retatide, right?

[00:04:55]There was more lean body mass loss.

[00:04:57]Okay? And it makes sense because chronic activation of a catabolic hormone could potentially cause you to lose more weight, raise metabolism, but also potentially sacrifice more muscle. Now, in the phase three Retatide trial data, they haven't shared the results all the results of the DEXA scan. So, we don't know how much of the of the weight was lean body mass, right? How much of the weight they lost was lean body mass? We don't know yet.

[00:05:20]I did look at how much weight they lost relative to waist circumference decreases, which is a very good proxy of how much actual fat they're losing. And Tirzepatide, you know, seems to be better for body composition because with Retatide, you have to lose 22% more weight, so more weight to get the same waist reduction, okay? Which is an indication, it's a proxy of more lean body mass loss. So, here is sort of the final message here, right? The final message here is, if you can get lean and stay lean with tirzepatide, specifically a low-dose tirzepatide, that's the best possible option, okay? You don't get as much of an increase in the in the heart rate, right? You don't get as much of a suppression in HRV. If you look at the trial data, uh tirzepatide is better tolerated, less people dropping out, okay? Less GI side effects with tirzepatide. So, tirzepatide to me is kind of the Goldilocks version. If you can get lean on a low-dose tirzepatide, that is the best option. If you're stuck on tirzepatide, you raise the dose, you're still stuck, and you need something more powerful to induce a deficit, to induce weight loss, that is where that is where retatrutide comes in. But, for most people, if you have a good eating plan, right? A good nutrition plan to follow, you're getting in your steps, you're lifting heavy weights, it is pretty damn easy to get lean on a low-dose tirzepatide. And so, that's going to be the better choice for, you know, you know, heart rate, less stressful on your system. You know, there is retatrutide is still being studied.

[00:06:43]They're still figuring out, you know, this triple you know, the triple agonist, right? They're still figuring out chronic glucagon. Is that an issue having chronic activation of glucagon?

[00:06:50]You also get better improvements in HbA1c, which is an indication of insulin sensitivity with tirzepatide, right? So, you know, basically, retatrutide is just more powerful for someone that needs that. But, for most people that have proper lifting, proper nutrition, and they just need a little bit of support being in the deficit, creating fat loss, tirzepatide appears to be the better choice. I would say for most people, start with tirzepatide. Start with tirzepatide. If you're getting amazing results and feeling good, stick with it.

[00:07:16]If you're at a plateau, you can look at using retatrutide. Now, there is a small amount of people using tirzepatide, you know, a very small subset, that might feel a little bit tired on tirzepatide, right? And usually that's just the first couple weeks, and then it goes away. Um but, if someone feels a little bit tired on tirzepatide, and they want and they they benefit from a little bit more activation, a little bit more, you know, increase in resting heart rate, they feel a bit more energized on retatrutide, that's something that you can test for yourself, okay? And you could test it, right? If you can get access to legal, safe Retatide, right?

[00:07:49]And so, that's kind of a personal thing, but, you know, overall for body composition, right? And overall health, and just more long-term data, tirzepatide is the better tool if you can get lean stay lean using a low dose of tirzepatide. If you need something more powerful than Retatide makes sense, okay? But, the people that would benefit the most from Retatide are the people that have the most fat to lose, that have the hardest time with weight loss, that have the hardest time creating a deficit, and the people that just want to, you know, that are fit, that work out, that just want to lose whatever 10, 20, 30 lb, that just need a bit of support, they're better off getting better, you know, body recomposition with a low dose of tirzepatide, you know? So, a lot of people do have it backwards. You can go fact-check this with ChatGPT or Claude.

[00:08:32]Um but again, right? Tirzepatide is going to be more gentle on your system, less increase in resting heart rate.

[00:08:36]Okay, a lot of the increase in resting heart rate you get a subtle increase in resting heart rate on tirzepatide, but then it comes back to baseline. Whereas, because you're activating glucagon, right? The catabolic stress hormone with Retatide, that increase in heart rate doesn't alway- always come down, right?

[00:08:50]It might stay elevated for a while, and for some people it will disrupt sleep.

[00:08:53]And for me, that's not something I'm willing to sacrifice on, the sleep, okay? But it's still, I have not tested Retatide. So, basically, you can go fact-check this, look it up for yourself, and choose the better tool for yourself. If you really need help and support creating a deficit and tirzepatide is not doing the job, then you can look at doing Retatide if you can get proper potency, purity, okay?

[00:09:13]Now, for someone that has made the choice where tirzepatide is a great tool, and you're here in the US, and you want access to pharma grade, it's compounded for you, you get everything you need, it ships to your door in 2 to 3 days, right? Then you can use the Kino Clinic, okay? You can fill an intake form, and you can order it from there, right? And then it basically, if you get approved for a microdose, you have to be at least a 20 BMI. For a macrodose, you have to be at least 25 BMI BMI to qualify. And this is not for anyone that has any eating disorders, right? If you have any eating disorders, okay? If you have any serious health issues, then you got to, you know, go talk to a doctor, right? Um, but if you're looking for, you know, microdoses, you can use the clinicaltrials.com. That's pretty much it, okay? Make the best choice for you.

[00:09:50]If you have any comments, questions, you want to share your results, you can share it below. And then, I don't When this video comes out, like June 6th, they'll be releasing the DEXA scan data, right? From the phase three liraglutide trials, and that's where we'll see how much of the lean body mass in phase three, you know, how much of the weight loss is lean body mass. And, you know, my prediction, you know, at the time of filming this is, you know, tirzepatide was 25%. It's probably going to be higher than 25%, which, you know, to me, I would rather get better muscle recomposition. Now, of course, this is done on people that are overweight or obese. Obviously, if you lift heavy weights, right? If you eat protein, you can maintain higher amounts of lean body mass loss, but will the chronic activation of a stress hormone catabolic hormone, you know, still work against someone that's lifting, eating protein?

[00:10:33]I would say tirzepatide for muscle retention is still probably going to be the safer bet for someone that works out, lifts weights, hits protein, they might get better body recomposition on tirzepatide, but whatever. The choice is yours. That's it, guys. Hope this is really, really helpful. If you have any questions, you can comment below, and I will talk to you soon. Bye.