Non-Hodgkin B-cell lymphomas and key aspects of integrated molecular diagnosis

Ajouté : 2026-05-19

[00:00:01][music] >> B-cell non-Hodgkin lymphomas constitute a heterogeneous group of lymphoid neoplasms >> [music] >> that arise from different stages of B-cell differentiation and exhibit a wide range of clinical and biological variability. Their classification is based on the integration of morphological, immunophenotypic, and genetic criteria, allowing for the distinction between indolent and such as follicular lymphoma or marginal zone lymphoma, and aggressive forms such as diffuse large B-cell lymphoma. In fact, these neoplasms originate from specific molecular alterations, including gene rearrangements [music] and mutations that affect proliferation, apoptosis, and cell maturation mechanisms, [music] thus influencing their clinical behavior and response to treatment. From a histopathological perspective, each subtype presents characteristic architectural and cytological [music] patterns, which must be evaluated in conjunction with [music] the expression of immunohistochemical markers specific to the B-cell lineage, such as CD20 and other antigens [music] associated with different differentiation phases. Furthermore, cytogenetic and molecular studies provide [music] relevant prognostic information by identifying translocations and recurrent genetic alterations [music] that influence disease progression.

[00:01:35]Consequently, the diagnostic approach to B-cell lymphomas requires a systematic evaluation that combines morphology, immunophenotype, and molecular biology. This allows for precise stratification and the selection of therapeutic strategies tailored to the tumor profile.

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