In acute leukemias, clinical features primarily result from the replacement of normal bone marrow cells by leukemic cells, causing anemia, thrombocytopenia, and neutropenia, as well as infiltration of leukemic cells into extramedullary organs causing hepatomegaly and splenomegaly; gum hypertrophy due to leukemic cell infiltration is characteristically associated with AML-M4 and AML-M5 (acute monocytic leukemia).
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