Vitamin K2 activates proteins (osteocalcin and Matrix Gla Protein) that direct calcium to bones and prevent arterial calcification; MK-7 form is more bioavailable than MK-4, and adequate K2 intake is associated with significantly reduced coronary heart disease mortality and improved arterial stiffness.
Deep Dive
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Deep Dive
Did You Know Calcium Can Harden Your Arteries? (Vitamin K2 Explained)Added:
Did you know calcium can harden your arteries? Not because something went wrong, because one vitamin was missing.
And almost nobody taking calcium or vitamin D knows about it. K1 handles blood clotting. K2 roots calcium into bone away from arteries. They do not substitute for each other. Eating greens gives you K1. You get essentially no K2 from them. Vitamin D absorbs calcium into your bloodstream. Two proteins decide where it goes. Osteocalcin into bone, MGP blocking artery walls. Both need K2 to activate. Without it, neither works. The calcium has no direction. If you supplement K2, form matters. At nutritional doses, MK4 was not detectable in serum even after seven consecutive days.
MK7 absorbed and lasted up to 48 hours from a single dose. Most supplements use MK4. A 10-year study of nearly 5,000 adults found the highest K2 group had a 57% lower coronary heart disease mortality, specific to K2, not K1. Two 3-year trials found 180 micrograms of MK7 per day reduced arterial stiffness and slowed bone mineral loss.
A 2022 meta-analysis of 16 trials confirmed the bone finding. Natto is the richest source by far. Hard cheeses, egg yolks, chicken liver, grass-fed butter.
Food first. If you supplement MK7 with fat, same window as vitamin D, once daily. K2 roots what D absorbs. Calcium is next. Everything cited. Cite your meal. We show our work.
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