A study of nearly 11,000 participants in the Australian Parkinson's Genetics Study reveals that Parkinson's disease presents differently between males and females: women are more likely to experience falls, pain, depression, and anxiety, while men report higher rates of cognitive changes and sleep disturbances, demonstrating that Parkinson's is not a one-size-fits-all disease.
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New Insights into Parkinson'sAdded:
There are 10 million people [music] worldwide that live with Parkinson's disease. This includes about [music] 150,000 Australians. In this study, which is the first publication coming out from the APGS cohort, [music] we analyze data from approximately 11,000 participants. [music] Parkinson's is much more than a movement disorder. They reported that [music] 96% experience sleep disruptions, 52% [music] experience back problems, 30% experience depression. In this study, we find that there are differences [music] between males and females in their experience with the condition. In males, [music] they tend to experience more cognitive impairment [music] and issues with their memory. Whereas in females, they tend to experience [music] more pain, falls, and mood-related [music] symptoms such as depression, anxiety.
There are some recent studies that show everything we know so far about disease [music] genetics is focused on the susceptibility, but it doesn't predict [music] the long-term outcomes for someone who already has the disease. We can't design [music] better treatments if we don't first understand the disease and understand the etiology. [music] And that's why studies like this one are important.
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