Genome in the Garage Song #Genome #Garage #compgenomebiol #song

Added: 2026-05-04

[00:00:03][music] >> We've got a massive genome, [music] billions of bases long.

[00:00:15]How do we [music] read it all without getting it [singing] wrong?

[00:00:21]The overlap [music] method was starting to break under the weight, so we [singing] pulverize to start to break under the weight.

[00:00:31]So we pulverize [singing] the puzzle for [music] the computer's sake.

[00:00:42]Oh k-mers, k-mers, breaking down the chain.

[00:00:47]Using the de Bruijn and de Bruijn graph to build up again.

[00:00:52]Connect the prefixes to [music] the suffixes, finding the right track, taking in your Eulerian underlay, walking, [music] never looking back.

[00:01:03]You've got to choose [singing] the right k, not too big or [music] too small. If the pieces are too tiny, it makes no sense [music] at all.

[00:01:14]Count up the frequencies, plot [music] them on a chart.

[00:01:21]Plot them on a chart.

[00:01:23]>> [music] >> Genome Oscope will tell you the genome size [music and singing] before you even start.

[00:01:34]>> [music] >> Oh k-mers, k-mers, breaking down the chain.

[00:01:40]Using the de Bruijn and de Bruijn graph to build up again.

[00:01:45]Connect the prefixes [music] to the suffixes, finding the right track, taking in your Eulerian underlay, walking, never looking back.

[00:01:56]Watch out [music] for the sequence errors, they make a little peak on the left. Homozygous [singing] has surjection, it's the hidden repeats that we seek. [music] From Sanger to Sanger, Illumina to PacBio's, PacBio, long read k-mer mathematics [music] is is exactly what we need.

[00:02:18]Yeah, k-mer mathematics [music and singing] is is exactly what we need. De Bruijn and de Bruijn believe, [music] we finally succeed.

[00:02:28]Mhm.