The Brain’s “Gas vs Brake” Failure in Huntington’s

Added: 2026-05-05

[00:00:00]In Huntington's disease, neurons in the indirect pathway which are responsible for suppressing that movement degenerate first. So with decreased inhibition of the phalamus plus increased movement, we see cora. The brain isn't overactivating movement, it's literally the loss of ability to suppress the movement. But then as we get later in the disease, there is widespread degeneration of these neurons including that direct pathway. So now that we don't have anything to facilitate or promote movement, we have hypocinetic movement.