Retatrutide Leads to 70 Pounds Lost on Average #weightloss

Added: 2026-05-25

[00:00:00]There's a new weight loss drug that is still in research that is making headlines and the results are turning heads. Eli Lilly just announced phase three clinical trial results for an investigational medication called Retatrutide. A phase three trial is one of the final large studies that need to be reviewed by the FDA for approval. It usually involves thousands of participants and it tests both safety and effectiveness. In this trial, people taking the highest dose lost an average of 70 lb over 80 weeks.

[00:00:30]That was about 28% of their body weight.

[00:00:33]Nearly half of participants lost 30% or more, which is a level of weight loss usually associated with bariatric surgery. Retatrutide is an investigational once-weekly triple hormone receptor agonist that works differently from current medications. It activates three hormone pathways at once helping control appetite, metabolism, and energy use. Retatrutide causes side effects similar to other drugs in its class.

[00:01:01]Mostly stomach problems like nausea, diarrhea, constipation, and vomiting.

[00:01:06]A small number of people reported tingling or numbness and urinary tract infections. Many of these issues were mild or went away while people stayed on the drug. It's still investigational, but if future results hold up, this could represent one of the most powerful weight loss medications we've seen so far. Follow Science My Health for more health research news.