Imugene's Phase 1b basket study of azer-cel, an off-the-shelf allogeneic CAR-T therapy targeting CD19-positive blood cancers, demonstrated an 81% overall response rate across 16 CAR-T-naïve patients, with 100% response rates in marginal zone lymphoma, chronic lymphocytic leukemia, follicular lymphoma, and Waldenstrom macroglobulinemia, while diffuse large B-cell lymphoma showed 60% response and primary CNS lymphoma showed 50% response; the company has also initiated a new cohort evaluating azer-cel in combination with BTK inhibitors for patients who previously failed BTKi therapy.
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IMU Imugene 81% Response Rate - ASCO May 2026追加:
Imugene has reported an 81% response rate for Azer-Cel in CAR T-naïve blood cancer patients. Here's the breakdown.
Imugene, trading on the ASX as IMU with a $40 million market cap, has reported an 81% overall response rate for Azer-Cel. It's off-the-shelf allogeneic CAR T therapy targeting CD19 positive blood cancers. The data covers 16 evaluable CAR T-naïve patients from an ongoing phase 1b basket study across multiple B-cell malignancies. Four cancer subtypes achieved 100% response rates, including marginal zone lymphoma with three complete responses and one partial response. Chronic lymphocytic leukemia with three partial responses, follicular lymphoma with one complete response, and Waldenstrom macroglobulinemia with one partial response. Diffuse large B-cell lymphoma achieved a 60% response rate, and primary central nervous system lymphoma recorded 50%. An updated data set will be presented at the American Society of Clinical Oncology annual meeting on May 29th, 2026.
Imugene has also opened a new cohort evaluating Azer-Cel in combination with Bruton tyrosine kinase inhibitors targeting patients who previously failed BTKi therapy. Be sure to add IMU to your watchlist and follow Stockhead X on socials to get breaking ASX news like this delivered directly to your feed.
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