PCOS (Polycystic Ovary Syndrome) is not caused by insulin resistance, as evidenced by the Rotterdam diagnostic criteria which includes three hormone-related factors (irregular periods/ovulation, ovarian follicle count or AMH levels, and testosterone-related symptoms) without mentioning insulin resistance, and the clinical evidence that metformin (a drug designed for insulin resistance) is largely ineffective for PCOS treatment, with only about 5% of women responding well to it.
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Fertility Myth 8 - PCOS is due to Insulin Resistance. #pcos #pcosawareness追加:
Fertility myth number eight, PCOS is due to insulin resistance. I mean, if you do a Google search, you'll find that this is a very prevalent uh theory or even practice. Uh so, and that's linked to, you know, weight gain and things like that. Uh it isn't. I mean, PCOS is not directly caused by insulin resistance. Let me explain. Uh the Rotterdam criteria sets out three separate criteria. First one is about period cycles and ovelation. Second is about how many follicles in the ovary or whether your AMH which is a hormone is too high. The third is about whether you have symptoms or skin problems or hair problems which are caused by high testosterone. So if you look at the three separate criteria that sets out by the W of them criteria which is a formal diagnostic scheme for PCOS or of which all three of them are related to hormones. There's no mention of insulin resistance at all. Now if PCOS is caused or underpinned or associated with insulin resistance why is there the off formal diagnostic criteria not mention it? The second reason why PCOS is underpinned by insulin resistance is a myth is that doctors have tried using uh medications such as metformin which is designed for diabetes uh to deal with PCOS and it's largely unsuccessful. In fact, I was told by a consultant that only 5% of women respond to metformin uh very well and uh and NHS is now withdrawing or or not really encouraging doctors to to prescribe it. So, a a medication that is designed to deal with incident resistance doesn't work. The formal diagnostic uh framework for diagnosing PCOS has not included insulin resistance.
So therefore PCOS is underpinned by insulin resistance is not is a myth. It is not true.
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