Statins, which block the mevalonate pathway to lower cholesterol, also inhibit the same pathway that cancer cells depend on for growth and survival, potentially slowing tumor proliferation and improving patient survival rates.
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Deep Dive
The mechanism that causes statin side effects also makes it a repurposed drug for cancerAdded:
Could the statin side effects that you hate actually help you survive cancer?
Sounds crazy, right? But the same pathway statins block for cholesterol is something cancer cells [music] desperately need to grow. Statins don't just lower cholesterol, they shut down the mevalonate pathway, [music] your body's factory for cholesterol, hormones, CoQ10, and other building blocks. That's why some people get muscle pain and fatigue. But here's the twist. [music] Cancer cells are addicted to the same exact pathway. They use the metabolites to multiply, spread, and stay alive. [music] Block it and cancer cells slow down, stop migrating, and die off more easily.
Multiple studies now show cancer patients on statins [music] have better survival rates than those who aren't.
This is not a replacement for treatment, but it's a fascinating example of how old drugs can have powerful new effects.
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