Type 1 diabetes can be functionally cured through islet cell transplantation combined with immunosuppressive therapy that protects the transplanted cells from immune rejection without causing toxicity; recent clinical trials have demonstrated that patients with type 1 diabetes can achieve normal blood sugar control (A1C levels below 6.0) within 4 weeks of receiving transplanted islet cells protected by a new drug (Tegopart), representing a significant breakthrough in diabetes treatment.
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We Finally Cured DiabetesHinzugefügt:
Uh in in really good news, chat chat in good news.
>> Pharmaceuticals was just featured in HCP Live, which is healthc care professionals live. This article is talking about their phenomenal results in functionally curing people with type 1 diabetes. 12 people to be exact. This is really recent. By the way, March 16th. I'll also tell you guys a lot of times whenever like I've had friends for years link me articles like they'll randomly link me articles like oh my god look they cured type two di or they cured diabetes and it's like usually something about type two or like oh my god look they cured diabetes and it's usually just not aure I want you guys to know what they did here is actually the is the theoretical cure because the theoretical cure has to do it has to do like that I can tell you what the cure for diabetes is. It's not like it's not like I think a lot of people think that cures for certain diseases are like oh my god we created this novel new protein this new synthesis crazy and it and it it it kills the virus and now you're like it's a vaccine or something like something like no the the cure the cure for diabetes was always really simple it's a transplant you like I literally am missing the cells right so you have to transplant eyelet cells and then you have to protect them. It's literally that.
Transplant the cells, protect them from my immune system.
Very simple.
>> HCP Live is generally targeted towards physicians, but I'm going to bring this awesome article to you guys. It was authored by now. Whether you do it successfully or not, >> if you have not been following this trial, Elodon has functionally cured 12 people with type 1 diabetes. Below me is a graph showing the A1C's of three of those patients. Also, I really like how they frame this in terms of A1C's because it's not were you able to produce insulin, it's were you able to produce insulin and and were we basically to undo the effects of diabetes.
>> You can see >> very simply, he says, yeah, it is really simple. The cure for diabetes is very simple.
I I literally just told you it. You transplant eyelet cells and you make it so that their immune system doesn't kill them. That's the part that's complex. It turns out by the way you can go like we could do eyelet cell transplants any time. Anyone could have done that. They've been doing that for years.
The the in nature or like in terms of like what you're trying to do it actually is very simple. Then actually doing it in an effective way obviously is very complicated.
See how they started at 7.8, 8.7, 7.3, and now their A1C's have all dropped within four or five weeks to the low fives. They're all functionally cured of type 1 diabetes with no toxicity and no adverse effects. So these 12 patients, >> the no adverse effect is like the one that they would want to track long term.
>> Received new pancreatic eyelet cells.
>> So that was step number one. They got new pancreatic eyelet cells. That part's easy. We've could have we've could have done this decades ago. That part's easy.
Always easy.
>> That regulate blood sugar. And Elidon's drug, which is a C >> Eladon. So that's what they're saying.
That's the new drug. That actually is the new thing that they synthesized.
And I'm pretty by CD4 I I I have a question.
Did the did the research on GLPs because I see GLP and then CD40L. I mean, are that is that research linked? CD40 lian inhibitor called tego proubart prot >> liden inhibitor >> protected those cells from rejection and it did so without causing any toxicity or adverse effects. If you just gave someone with type 1 diabetes new pancreatic eyelet cells without protecting them with eldon's drug they would be dead within hours.
>> Yeah. Like if you put that's the thing is if you if you give someone a eyelet cell transplant well not anyone but again if you give a type 1 diabetic an eyelet cell transplant the same thing that killed their eyelet cells in the beginning will just kill them again. So Elodon's drug is protecting these cells phenomenally well while avoiding calcinurine inhibitor toxicities. They're talking about tacrolymus which has been the standard of care for all organ transplant for the last 30 years. It's a really terrible drug with lots of toxicities and side effects. The next point says that rapid blood sugar control was observed by four weeks with a tight A1C control. The next point says that there Yeah, I was going to say what's crazy is how fast like theoretically how fast this would work.
It's not like oh my god like you'll eventually be it like it it would literally you would start noticing a difference within a week and then yeah probably be like cured within four weeks. There were no rejection episodes and there were no antibbody productions that would try to kill off these new eyelet cells. If getting these 12 patients completely off is it like an instant cure. Yeah. I mean basically it it's basic here I can we'll Google paint this. Okay. The reason why it's an instant cure type hold on type hold type one.
In type 1 diabetes, you have eyelet cells. Okay, eyelet, which is actually spelled like this.
It's for like eyelet of Langerhorn. It's some random name named after the guy.
Okay, you have your eyelet cells and these produce insulin.
Then you have autoimmune autoimmune response.
This is the part that's like it's like a genetic thing that they don't fully understand or why it happens.
And then Your immune cells go and they kill your eyelets. This is the this is the basic thing. Okay. Type type type one type diabetes. You have eyelet cells.
Cool. They make insulin. There's an autoimmune response. Your your own I don't know if they're white blood cells or whatever, but your own immune system.
Your immune system, your immune cells kills your own eyelet cells. They go and kill them. What this is doing, what this is basically doing is it's a transplant that now puts these cells in your and then presumably your immune cells still work. These ones still work, but now they have some sort of like I don't know inhibitor on them. This is the new drug.
Won't kill. And now they won't kill your new eyelet cells.
Simple.
Simple. Our body is way too good at Well, so this is where you're sort of wrong, though. Our body is way too good at detecting that isn't ours. No, that actually isn't the issue. Pause. You're No, pause. Rewind that. Rewind that.
These are your immune system killing your own.
This is actually your body not being good at detecting what is and isn't yours because it's actually your it's actually the opposite of what you're saying.
It's your body not realizing that that's your own so it kills it. And this is now tricking it into saying no, this stuff is okay.
It's also why it's it's also why there's a lot of frustration with from type 1 diabetics as to why we don't like being lumped in with type 2 diabetics because they're just different diseases entirely.
Like they they're just so so different.
Anyway, so this is theoretically how you'd cure diabetes.
off of insulin by about a month after cell trans >> and then so when someone asked so you cured it yeah I mean because all all you need to cure diabetes all you need like you're just fully cured is again when when we say type 1 diabetes we mean you don't have insulin producing cells like type one equals no insulin producing cells. Type two equals insulin resistance.
Type two is just completely different.
Type two, not type equals and insulin resistance means you still have cells producing insulin. your body is just not sensitive to insulin anymore.
Now, that can be caused by a number of things. That's not to like there are genetic components. There's a lot of factors that go into type 2 diabetes.
If you live old enough, you will develop some for like your body eventually just gets more resistant to insulin. I will be honest with you, and this is just this is the hard truth. Most of the time, it's because of poor diet.
Like most of the time this is poor diet and again type two diabetes is reversible.
Type two diabetes is has always been reversible.
Not for everyone but for a lot of people it's it's reversible. Type 1 diabetes is not that there's no there's no cure.
There was no cure for it. There's no revert. Like there just it is what it is. Unless this works.
>> Transplant wasn't big enough news. And by the way, a month is extremely fast.
Yeah. So without causing any toxicity or side effects that typically come with tacrolymus, which is the current standard of care, which is a calcinurine inhibitor. It's a really nasty drug. So there are two huge things coming out of this article. They're functionally curing people of type 1 diabetes within about a month. And they're doing so without causing any toxicity to the kidneys, to the nervous system, or to the beta cells that produce insulin themselves. All of which happen with tacrolymus, the current standard of care. This is Elodon's CEO, DA Gross, and I want to read to you a quote from the article from him that is really exciting. He says patients with type 1 diabetes have been waiting decades for a potential functional cure and it is very encouraging to see meaningful progress in that direction through the emerging promise of Tegopart. Elodon provided HCP Live with a statement and I want you to pay special attention to the last sentence. Really exciting stuff. I'm going to move out of the way and read it. I actually am curious because the other problem with a lot of medical care is not and and maybe you guys will say this is me being a Debbie Downer or like I don't know just very negative about this stuff but when it comes to a lot of healthc care stuff I am very skeptical.
Um, and it's and one of the main reasons is this, like you're with someone's money here. Like as soon as you cure diabetes, you you with a lot of company's money and there's a lot of money in diabetic care. So, I'm wondering if the part he's going to cover now is around the politics of it because there is a a lot of people think that if you cure a disease, it's like, "Oh my god, I found the cure for cancer. Oh my god, I found the cure for diabetes." It's like, it doesn't work that way. like a lot of people will try to shut it down or limit it or you know there's a lot of stuff you got to do >> it with you. It says these latest findings support the potential of Tegopouart to enable effective eyelet graph protection while avoiding the toxicities often associated with calcinurine inhibitors and potentially enable access to eyelet cell transplantation for individuals living with type 1 diabetes. We are proud to contribute to these important ongoing research efforts and support the work of Dr. Wikowski and the team at Chicago Medicine. Whoa, whoa, whoa, whoa, whoa.
And the team at Chicago Medicine.
Put some respect on that name. That I didn't even know this. That's you.
Chicago medicine. Yo, [ __ ] Shout out alma mater. That's right.
Yeah, that's right, Chad. I paid a lot of money to go to school for a degree I don't use.
And here's the really exciting part. We also look forward to working closely with the FDA towards our goal of receiving regulatory guidance on a path to market approval in eyelet cell transplant later this year. You guys, they are planning on meeting with the FDA this year to discuss a pivotal trial design so that they can receive approval for this indication to functionally cure type 1 diabetes.
>> I'm gonna get queued in on this. I'm paying out the wazoo. I'm using my [ __ ] healthcare privilege to take care of this.
>> If that doesn't get you excited, I don't know what does. I'm going to finish off with this really exciting data that they posted in the article. So, the average person in this trial had type 1 diabetes for 33 years and their average A1C was 8.0. And then after just 4 weeks after their eyelet cell transplant, their A1C's were below 6.0. And to date, they checked the first 10 patients and their A1C has an average of 5.35.
The only reason why the last two weren't included is because they were dosed very recently. And we know number 11 is already off insulin and number 12 should be off any day now. If you missed my last video about the FDA, this is chat.
I would I would I would empty my I'd empty stocks to pay for this if if so like you have to understand like if if if if you were like yo like would you pay $100,000 to just get this done today? Yeah, I'd pay 100k for this. Like that's how important this is.
>> Dr. Marty Mackery who is >> remember we talked about lifechanging.
This is lifechanging.
>> The commissioner of the FDA right now.
He got up just a few days ago, last week, and he talked about how he wants to see a cure for type 1 diabetes, and that was the first disease he listed when he started talking about cures for diseases. So, the FDA is laser focused on this as well, you guys. This is really exciting stuff. We have big news for the type 1 diabetes community.
>> I'm going to try and get in on this. Oh my god. I can maybe I'll maybe if I ask them maybe they'll let me maybe they'll they'll help fund it or like they'll make it. This is where I should use my influencer card, guys. What if I'm like, "Yo, what's up YouTube? Today I'm going to try curing my diabetes."
But first, a shout out to today's sponsor.
If you build up some charity, I'd put in I mean depending on I mean like hopefully it wouldn't be that Listen, I would tell you guys this. I will tell you this.
if this becomes something like that is accessible or like is something that we can get but is a it's a cost thing where it's like maybe it costs like I don't know like $5,000 or however much money to get done. I will fullon dedicate charity streams and just I will only stream to raise money to and cure people of their diabetes. I'll just I'll pivot the entire course of my stream.
Blow. How are you cutting? You still didn't have one Coke Zero. Dude, Coke Zero is is like Oh my god, chat.
This is the crack cocaine. This is the greatest thing ever. If you want to cut it, fills you up. It's sugary and sweet.
Oh my god. The greatest cutting tool ever, Coke Zero. So good. I do think one of my favorite things is that one guy where he like explains health and nutrition for you.
Like you have CTE and there's all the people like, "Oh my god, but if I drink Diet Coke or Coke Zero, what about the aspartane?" And and I love where it's like, hey, so to reach the like minimum toxic threshold for aspartane and and aspartane is apparently one of the most studied like drugs or like most studied like food supplements ever.
But what is it? You have to drink like um I think it's like 238 cans a day or some [ __ ] It's like it's like an insane amount.
It's like the amount of of Diet Coke or Coke Zero you'd have to drink every day.
It's like daily too is like it's insanity.
Also, beer back shot. I got to pee.
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