IV Adrenaline Infusion in Anaphylaxis ⚠️

Added: 2026-05-20

[00:00:00]When do we start an adrenaline infusion in anaphylaxis? Usually in refractory anaphylaxis when repeated intramuscular doses are not enough.

[00:00:07]Regarding the doses for an adult, a common starting dose is around 1 to 2 micrograms [music] per minute, but remember this can reach still 10 micrograms per minute.

[00:00:15]Regarding the weight-based calculation, it becomes more simpler.

[00:00:19]For the pediatric age group and for adults, [music] it is starts with 0.05 to 0.1 microgram per kilogram per minute and then titrated carefully to response.

[00:00:28]For the dilution, take 1 mg of adrenaline diluted with 50 ml of normal saline, therefore giving you concentration of 20 micrograms per ml.

[00:00:36]And for an example, a 10 kg of child started at 0.05 micrograms per kilogram per minute will give you the infusion rate of around 1.5 ml per hour.

[00:00:47]Simply by 0.05 [music] into 10 kg into 60 divided by in the denominator by 20, therefore giving you 1.5 ml per hour. Therefore, start low, go slow and titrate to blood pressure, perfusion, airway stress test, and heart rate. So, save this one for your next ICU shift.