The APOE4 gene variant is a genetic risk factor for Alzheimer's disease, where carrying one copy affects approximately 1% of the population, and carrying two copies significantly increases risk; however, it is not a deterministic gene, meaning it only indicates increased vulnerability rather than guaranteeing the disease will develop.
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He found out he’s at high risk… then discovered BOTH parents are too追加:
Do you have a greater vulnerability to Alzheimer's?
He told me that and I was like a moment of sort of shock, a moment of what does it mean, and then about 15 minutes later I was like, ah, just something old people get, whatever. I told my parents about it, and I remember my dad saying, ah, look, don't worry about it, we'll figure it out. That's, you know, you don't And I was like, yeah, I'm not concerned, it's just this [music] strange thing to be told, and he was like, like it's fine, mate, you know, plenty of time, we'll, you know, figure out what you need to do to prevent it and so on.
And I remember vividly that conversation of him sort of telling me not to be concerned about it, and then about [music] two or three years later my mum saying to me, I think we've got to get dad checked because there's these signs [music] and things I'm concerned about.
Um, the obvious ones memory and sort of slight mood changes and shifts and forgetfulness and so on.
>> [music] >> So we he went and got tested and um, found out he had two copies of the APOE4. Um, as did my mum, which so you've got one in the one in the 1% of population is APOE4. What I don't know what the math is on and I put two >> It's not a pre-deterministic gene, it's it's it's just an indication [music] that you're
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