GLP-1 medications represent a revolutionary breakthrough in weight loss due to their significant efficacy, but they come with important trade-offs including metabolic adaptation (reduced energy expenditure), potential skeletal muscle loss, and the risk of weight regain upon discontinuation, which raises questions about long-term use strategies.
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GLP-1s & long-term weight lossAjouté :
I I think the major concerns now with GLP1s I mean that's two concern the the first is this metabolic adaptation and there is a hope that you can associate the GLP1 with something which would decrease this drop in algae expenditure and the second thing is uh and I think it's kind of misleading it's the belief that we lose a lot of skeletal muscle yes indeed this GLP1 have been a revolution for me at least to see the magnitude of the weight loss but it comes with some concerns and the concerns is metabolic adaptation and regain of weight and this loss this potential loss of skeletal muscle and of course a last thing that I should say is if you stop your drug you're going to regain the
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