Mark Ramzy, DO (@mramzydo) from ResusX:ReUnion talks recognizing and treating TTP. #shorts

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[00:00:00]This is a relatively young male who has a fever, altered, thrombocytopenic, acute kidney injury, and that rash.

[00:00:07]Well, if you said TTP, you are correct.

[00:00:10]Thrombotic thrombocytopenia purpura. And again, that's a mouthful, so we're going to say TTP. Well, this is an inherited or acquired deficiency of the ADAMTS13 gene. So, what happens here is you have von Willebrand factor, and ADAMTS13 gene cleaves von Willebrand factor into smaller multimers. Now, those smaller multimers can actually diffuse throughout the rest of the body and can cause some platelet clumping, microthrombus formation, and hemolysis. And in severe cases, pretty significant organ dysfunction.