Quick Summary of How to Make a Primary Amine #amine

Added: 2026-05-05

[00:00:00]And specifically what we just covered was different ways to form an amine. So we saw that here with reductive amination where yes we could either go from an aldahhide or ketone use ammonia and then notice we're just going to form a primary amine. Yeah. Versus when we have a primary amine we now are going to form a secondary amine. So it kind of like builds from there. Right now a secondary amine is going to give us a tertiary amine and we keep going from there. It looks a bit different from what we just saw with the aldahhide like the positioning of the amine right where instead when we had an aldahhide here the NH2 was on this side right on that end. So understanding that yes it does kind of switch a bit but it still would have been a primary amine. That makes sense. Okay. Next another way. Does this look familiar? Mhm. Going back to reactions of aromatic compounds, right?

[00:00:50]We have a nitroenzene and it doesn't matter which one we decide to use.

[00:00:55]There's a bunch of these that we can choose from. I'd say the majority of the time you're going to see iron and then acid be used and then the second step.

[00:01:03]Oh, okay. That's good to know. And then of course this reduces that nitro group to an amine. Mhm. Definitely know this one. Hint hint. That's good to know.

[00:01:10]Then we just covered the aid synthesis where we went from an alkaalhalide. Then we went to our alkaal aid. Then whichever reduction you decide to choose that will give us a primary mean. care.

[00:01:22]We also looked at this before with our carboxilic acids where we saw okay I have a caroxilic acid I'm now going to change this to my amide using these two steps and I know that first step would have converted it to an acid chloride then with the second step I get an amide then finally reduction gives me an amine okay Gabriel synthesis we also looked at that right we have phalomide which is what this is called then we have this entire portion of it where there's three different steps where we're going to make this into potassium phalomide. Then from there we add an R group. Then from there using hydroine we then form our primary amine. Okay. And the last thing here was another type. This goes back to SN2 reactions and reduction of nitrals where I start off with an alkaalhalide using either one of these. I then form that nitrial. Then I reduce the nitrial using any one of these combinations for reduction. And then I form my primary mean.