The Truth About Hypertension: Stop Treating the Symptom - Dr Trevor Bachmeyer

Added: 2026-05-31

[00:00:00]So, high blood pressure, I'm in one of these moods today. High blood pressure is hypertension is not a disease. It's not a disease at all.

[00:00:08]Like hypertension is a symptom. Just to be very clear, it's your biology screaming that something is broken in your internal terrain is the easiest way to explain it. And biology has made what I call a hydraulic calculation. And it says, "If I don't handle the pressure and raise it right now, this human is going to die."

[00:00:37]And what do doctors do? I've been a doctor almost 30 years, so I I'm But not the same as your doctor. Trust me.

[00:00:45]They're handing you a prescription to make the pump in your chest, which isn't even a pump, weaker. That's not medicine. That's not healthcare. That's I It's sabotage wearing a white coat with an with ignorance and arrogance wrapped around it. I It pisses me off.

[00:01:00]So listen, I will show you actual physiology of blood pressure and show you why your body is raising it and why the most common drugs to treat them are biochemically completely backwards. It's just basic physics and chemistry and it's how your biology actually works.

[00:01:15]I'll just give you the answers. What you do with it is up to you. How about that?

[00:01:18]So, how about I start with something that's so obvious that most people just miss it. The heart pumps fluid through these pipes. They're called vessels.

[00:01:25]That's it. Oh, no. You're waiting for more. That's it. That's the entire system. Pressure equals resistance in the pipes multiplied by flow rate. It's basic physics. P= R * Q, right? That's physics. Rearranging. If resistance goes up, pressure goes up. If flow rate goes down, pressure has to go up because it has to maintain this thing called perfusion. Now, here's the ridiculously obvious problem with the modern medicine. When a doctor sees this elevated blood pressure, what does he think? Thinks the pump is broken. So, what does he do? He prescribes a drug that makes the pump weaker. It's a beta blocker which slows the heart rate, reduces contractility, which reduces this thing I just said you need called flow rate. So, according to his own equation, P= R * Q. If you reduce Q, which is flow rate, right? If you don't understand physics, that's fine. Flow rate and resistance is still elevated, what happens to pressure? it should stay elevated or go higher, right? But it doesn't. That's the problem because what actually happens is your tissues don't get enough oxygen and your body being as genius as it is senses this. Your sympathetic nervous system activates harder to compensate and you develop even more problems. This is why patients on beta blockers develop metabolic dysfunction, depression, sexual dysfunction, and increased cardiovascular event rates. You haven't fixed the damn thing. You've just made the problem worse while making the number in the machine look better. The gauge looks better. The labs look better. So, let me back up because here's the real story. The story about why pressure is elevated in the first damn place. It's way more interesting anyway and I'm just like this. There's some things that I'm just in a mood. So, three things breaking down that force your biology to raise blood pressure and they all work together in this vicious feedback loop that makes your situation worse the longer it goes untreated. So, insulin resistance, watch, here's how it works. I'll give you the basic hierarchy. Insulin resistance. Insulin resistance causes sodium retention which causes increased plasma volume. And if you don't know what that means, I'll explain. So 1998, Gerald Reven, the researcher who basically discovered metabolic syndrome, published research showing that insulin resistance forces your kidneys to retain sodium. Here's the mechanism. So insulin is supposed to activate something called the P13K pathway into your endothelium. It's the lining of your vascular system. The pathway tells your kidneys, "Hey, we have enough sodium. Excrete the excess."

[00:03:36]But when you're insulin resistant, which is like 80% of the population here in North America now, no, I'm not kidding.

[00:03:41]It's that big of a number. This pathway is defunct. It's shut down. So your kidneys think there's a sodium def deficit. They retain sodium. So osmotically, water flows where sodium goes. So it follows sodium into intravascular space. Your plasma volume explodes. Your blood become becomes thicker. So now it's like molasses instead of water. And here's where the physics gets incredibly brutal. Watch.

[00:04:04]I'll I'll help you. Okay? Take your garden hose, fill it with water, run 40 PSI, and you'll get a certain flow rate.

[00:04:08]Agreed? Okay. Fill that same hose with syrup to get the same flow rate. You need 100 PSI. That is your That's 100 PSI. That's your biology. Your tissues are freaking out for oxygen. Biology doesn't think, "I don't know, man.

[00:04:22]They've got hypertension. I better not do this." Biology goes, "The tissues aren't getting enough oxygen. The blood is too thick. I need to crank up pressure to force oxygen through this sludge, otherwise this thing is going to die that I'm responsible for." So, it raises pressure. The heart is literally saving your life by pumping harder. And the doctor gives you a beta blocker to make the heart pump less forcefully, which creates systemic hypoxia, which worsens every disease process in biology. And you walk around congratulating yourself while you pat yourself on the back going, "Oh man, look at me. Look at my hypertension's managed. I'm doing so great, man. This is a game. It's a con. Look at the nitric oxide." Okay, look at watch. Back up. Systemic inflammation. Okay, this is the second failure. I have three biological failures. insulin resistance, systemic inflammation, and mitochondrial dysfunction all the time. Every disease, it is every single disease on Earth.

[00:05:08]Where's my Nobel Prize? No, I'm not kidding. I don't care about the money. I want the recognition that I solved every frigin disease. I just want that so people can and I could just bury the medical industrial complex. $2.2 trillion. They got bigger bank account than I do. So, it's an uphill battle. I feel like Seephus every day pushing that freaking stone. But here I am with my coffee in hand and my gun beside me. Oh, I'm a gritty doctor cuz I care. By the way, a lot of people are going, "How do I work with you?" I get messages by the thousands every day. And thank you. I'm humbled by that. Really, I am. Like, thank you for trusting me with your health. And I hope all of you guys that take something from my podcasts or my posts or whatever, you're solving your biology. I love the messages that you send me on social media when I do my AMA, my ask me anything, and you guys put in that little white window. It warms my heart, man. Really, it makes me smile that when you say you saved my dad's life or you reversed my kidney disease or you my whole family is healthy because of you. Like all the things that you send me. Thank you.

[00:06:05]That's why I do this and I haven't asked for a dime from anybody. I just want you to do it. Go out and do something good with your damn biology. But if you want to work with me directly, of course there's a fee. It's my career. It's my job. So when people get mad, they're like, "Oh, you have a fee? I thought you care about people." Pilots care about people, but they also get paid to fly the plane, right? I don't know. It's called my job. It's my career. So, the reason I'm saying this is because if you want to work with me, you need to send Mia, my personal executive assistant, who is a savage ombre Brett, it's a girl, right? So, send her an email apply at unlockthecard.com up until the end of this month. It is $12,997.

[00:06:42]It's not a push or scarcity or anything like that. It's just I'm raising my fees. It is for one year for one person.

[00:06:48]you get access to the VIP community where you can send me your labs and all your stuff and I'll help you with everything I've got. And I will spend a year breaking my biology to save yours because I care. I care. I have so many video testimonials 6 7 8 minutes long that if you're listening to this and you're in my black card group, I am so honored by those things. They matter to me so much and I love you for it. But that means I'm doing my job. That's my point. I'm doing my job because I care.

[00:07:15]But if you want to work with me, that's how you do it. get access to my weekly live Q&A call that I do every Monday at 5:00. I'm just east of Dallas, so you do the math wherever you are. So anyway, the point is that if you want to work with me, it is 12,997. You get access to the VIP area. You get access to the protocol library, but don't Yes, it's awesome, but you're we wind up tweaking it, modifying it anyway based on what we find in your biology. And it's a kick-ass community. I love these people.

[00:07:42]Even when I get on their butts for doing things that are a little bit careless, I still help them because I love them.

[00:07:47]It's like their family, right? And if you want to buy from my company, it's Elite Biogenics with an X, not a C. And I'm honored that you buy from my company, but I don't care if you don't.

[00:07:56]I come out here because I actually care about you. I don't care about the money.

[00:07:59]I care about you. I have plenty of money. I don't When people go, "Do you need it anymore?" I always want to be more successful because I'm building a legacy and a life for my two children and my wife. God forbid something happens to me. who wanted her to never.

[00:08:10]I couldn't imagine looking down from heaven. This stresses me out. I couldn't imagine looking down from heaven and seeing my wife in tears, struggling, having to go get a job because I didn't do mine. Take that however you want it.

[00:08:20]I don't care. By 50 years old, you should have stacked hundreds of millions of dollars. And if you get mad at that statement and get in my comments about it, that's your fault, not mine. I've been broke. I've lived in my car. I've had nothing. I've had things taken away from me. I've lost everything. So, I I don't have a lot of empathy because I've been at the bottom and I've been married for 20 years. She's my best friend. and we have two incredible kids and there's nothing I wouldn't do for my family. So, if you wonder the quality of Elite Biogenics from my labs, it's the same thing I give my wife and my children and I adore them. So, you do what you want.

[00:08:50]Anyway, you want to work with me, that's how you do it. You want to buy from my company, that's how you do it. So, look at let look at systemic inflammation before I get all over the place here.

[00:08:56]Systemic inflammation causes ENOS uncoupling, which causes the loss of nitric oxide function, which now you can't do a lot of things, never mind just dilating the vessels. It does more.

[00:09:07]But now you get vessel rigidity. So look at nitric oxide. Let's go over this a little bit. The molecule that won the Nobel Prize in 1998 first got Ignaro and Murad figured out how important this is.

[00:09:17]Yes, Nobel Prize. Go figure. Where's mine? It should say Bakmar. So nitric oxide is produced by endothelial cells that are lining your vessels. It's a vaso diilator. It tells vessels to relax and open up. When you have healthy insulin signaling and healthy endothelium, here's what happens.

[00:09:33]Insulin activates the P13K pathway which activates an enzyme called ENOS, endothelial nitric oxide synthes. I've talked about this plenty of times. Enos produces nitric oxide vessels relax and pressure drops. But when you're insulin resistant and systemically inflamed, which are married, by the way, you can't have one without the other. They're literally, I kid you not, they're inseparable conditions. They are married forever. Something catastrophic happens when you have this. The P13K pathway shuts down. Just it shits the bed. But another pathway, here's the issue called the MAP K stays wide open. MAP K cranks up something called endothelin one, which is a savage vasoc constrictor. So now vessels constrict instead of dilate.

[00:10:13]Oh, it gets worse. When you're chronically inflamed, your body is spitting out reactive oxygen species.

[00:10:18]Reactive oxygen species. One of them in particular is called super oxide. It's incredibly destructive. Super oxide. It oxidizes the tetrahydroofolate co-actor that enos needs to function. It's called enos uncoupling. So instead of producing nitric oxide, uncoupled enos, this is where it gets horrible, produces more super oxide, creating this ugly cycle of more oxidative stress and less nitric oxide. So your arteries become rigid, inflamed, calcified, and the elasticity goes away. Do you know what happens to your aorta? Every time your heart beats and goes through contraction, right?

[00:10:49]Every time the aorta has to go like this, it has to expand, contract, expand, contract. You can't do that if the vessel is rigid. 2016 study in hypertension by GAO showed that insulin resistant patients circulating endothelium levels were 40% higher than the controls and enos uncoupling was present was present all over the place that I hope was present was present in 87% of subjects 87% that's not rare that's a metabolic condition of modern humans you need to understand how bad this is and why it's such a money maker for this for the big pharma so look at and go let's get into the final one before I even tell you how to solve it cuz you're like, "How do I fix blood pressure?" I'll get to it.

[00:11:28]Don't worry. Mitochondrial dysfunction is the third biological failure that I came up with. Right? So, you have met mitochondrial dysfunction, which causes ATP depletion, which causes calcium handling failures everywhere. So, this is the third problem. Your vascular smooth muscle needs ATP in order to relax, not contract, relax. It's critical because ATP is the energy currency that allows calcium to be pumped out of the cell that allows the muscle to relax. If you wanted to know, now you know. But your mitochondria are dysfunctional. From 27 years of stupidity and ignorant decisions and refined carbs and booze and vegetable oils and a sedentary lifestyle, whatever other things you've done, your mitochondria now can't produce enough ATP. Don't get mad at me. Look in the mirror and negotiate with your boss.

[00:12:08]Vascular smooth muscle cells are now too tired to relax. Calcium gets stuck inside the cell. Muscles stay contracted. Vessels remain constricted.

[00:12:16]And do you know what biology has to do?

[00:12:18]Raise pressure to compensate. So 2017 study nature metabolism by Lopez Luch showed NAD+ levels the critical co-actor for mitochondrial function 50% lower in hypertensive patients compared to normotensive patients their mitochondria energy starved shot. So look at this here's the problem. So most people don't look at this but your kidneys play a massive role in this and they should because the renotensin eldoststerone system is controls everything. So your kidneys are filtering your blood.

[00:12:46]They're extracting waste products so you can urinate them out. This requires something called blood flow.

[00:12:51]Specifically, it requires oxygenated blood. But here's what's happening in your biology. The endothelium is inflamed, right? The vessels are rigid.

[00:12:58]Mitochondria are failing. So the profusion to your kidneys is compromised. They're not getting enough of this magic blood that's filled with oxygen. So your kidneys panic. They release rein. Arnan converts angotensinogen into angotensin one. Then ACE converts it into angotensin 2.

[00:13:13]Angotensin 2. Incredible vaso constrictor. and it screams at your vessels, squeeze. Why? Because your kidneys are yelling at your biology. If you don't squeeze, I'm not going to filter properly. You're going to poison yourself with your own metab your own metabolic waste. So, ureia, kidney failure, death, worse, right? So, your body raises blood pressure. It's not because the pressure is the problem because the kidneys are genuinely they need that pressure to function. 2013, look at this. I got to drink some coffee. 20 I'm sorry, I'm distracted right now. We have a we have a sick cat.

[00:13:41]I know some of you guys are like, "Oh, who cares?" You know what? I care cuz it's my son's cat and cats have personalities. That's what's got me distracted right now, by the way. And and it's bugging me because I never thought I would love this little cat, but this little seven lb tiger is just become part of the family and he's not doing so right now. So, it's got me stressed out a little bit. So, look, 2013 kidney international interesting because the cat has kidney problems.

[00:14:04]Showed exactly this. Okay. In hypertensive patients, intraral renan concentrations were elevated. So that shows local activation of the ren and angotensin eldoststerone system, right?

[00:14:14]So the kidneys are literally screaming for help. They're begging for help. And what does a doctor do? They give you something called a ACE inhibitor, which now blocks angotensin 2 production.

[00:14:21]Awesome. Which turns off the alarm. So now biology can just burn itself to the ground. You're not treating the patient if you're the doctor. You're silencing the damn alarm while the house is on fire. So look at the most common I got to do this because I wasn't going to, but I'm going to. The most common anti-hypertensive drugs. I'll show you exactly why they're biochemically backwards. Like I said, because people get so mad. Look at Leinipril, right?

[00:14:41]It's an as a ACE inhibitor. So, it blocks ACE. It stops angotensin 2 production. Vessels relax and pressure drops. Sounds logical, right? It does, right? Think about it. If you just look at the surface, it sounds like you're like, "Okay, Dr. Trevor, what's the big deal?" It's catastrophically wrong.

[00:14:54]Look, it you're blocking the very system your body activated to keep your butt alive. Your kidneys released rein because they genuinely needed that pressure. Angotensin 2 exists for a reason. God didn't build extra stuff in you. It's not just to constrict vessels.

[00:15:08]It's to regulate kidney profusion, electrolyte balance, vascular remodeling. Okay, so when you chronically block it, your body compensates by upregulating A2 receptors. That's a problem. 2020 study in Nature Reviews Cardiology showed this very clearly. These are the same receptors CO9 uses to infect cells. This is why COVID positive patients on ACE inhibitors have worse outcomes. Nobody's told you that, have they? That's just the beginning. You know what else they do? ACE inhibitors cause this dry cough and they go, "It's normal in about 40% of the patients." Here's why. Because ACE breaks down bradydinan. When you block ACE, bradydinan accumulates in your lungs and triggers this dry cough.

[00:15:43]Your body's literally trying to tell you something is wrong. I think we have been taught, I have to address this, we've been taught to think that these little the these little idiosyncrasies with our biology are normal. They're not. Those are signs and signals. They're warning lights flashing everywhere. You just have to find out what the underlying cause is, not treat the warning light.

[00:15:59]And I think that's where medicine has strayed because it's hunting profit and not solving problems. And yeah, it pisses me off. Look at 2015 study.

[00:16:07]Circulation showed long-term ACE inhibitor use increases myioardial infuction rates in most populations because you're disrupting a symptom, a system that's been designed by God to function a certain way. And here's the kick in the pants. 2012 meta meta anal metaanalysis and jamba. I'm all over the place today. Meta analysis and jamba showed that ACE inhibitors do not reduce cardiovascular mortality in patients at all. They lower the number, but they don't improve the outcome. So, let me get this straight. You're treating the number while the human tanks make it make sense. Look at Metropol or Tennol.

[00:16:39]Those are popular, huh? Beta blockers.

[00:16:40]They block something called beta adronergic receptors. They slow your heart rate and reduce cardiac output and your pressure drops. Why would you want to reduce this thing in your chest?

[00:16:47]Really, I want you to think about that.

[00:16:49]Why would you want to do that? It's doing it for a reason. Like when you have a problem, your car starts puking purple smoke out the back and it's rattling and banging away, you just turn up the stereo so you don't you don't hear what's wrong. That's what you guys are trained to think. Here's the problem. Your sympathetic nervous system exists for a reason. Okay, it does. It mobilizes your body. It's supposed to increase cardiac output when you need it. But when you chronically suppress it, very insidious things happen. 2013, JAMA, 3,000 patients, that's a big number. Stop looking at people's followings. That is a big number, showed the beta blocker group had massive rates of stroke and heart attack compared to all other hyper anti-hypertensives. Why?

[00:17:24]Because you've blunted the sympathetic nervous systems ability to respond to threat. You've lobotomized your body's emergency response system. Your tissues need less less oxygen when you're resting, but they need more oxygen during activity. You know what beta blockers do? They prevent your heart from increasing output during stress.

[00:17:39]So, tissues become hypoxic during the exact times they need oxygen the most.

[00:17:44]In 2002 circulation, they showed beta blockers increase insulin resistance and increase the risk of developing type 2 diabetes by over 25%. They suppress fat mobilization. They make your body metabolically dysfunctional. In depression, how about this? I could do this all day, baby. 2017 meta analysis in Jamba Psychiatry showed 20% increased risk of depression in beta blocker users, which makes sense because you're chemically suppressing the system responsible for mobilizing you in response to the world. You're making people biochemically depressed to lower a number in a stigma monometer. 2015 study in the Lancet that really should just drive this home. Beta blocker showed, you're not going to like this.

[00:18:22]People are going to argue. I don't care.

[00:18:23]I'm still right. Look it up. 2015, the Lancet. Okay. Beta blockers showed no mortality benefit in patients. None.

[00:18:31]They lower pressure. They do not save lives. I'm sure that'll get me banned somewhere. How about How about calcium channel blockers? Those are fun, huh?

[00:18:39]They block calcium channels in vascular smooth muscle, prevent contraction, so the vessels relax, pressure drops.

[00:18:44]Remember the ENOS, right? The endothelial nitric oxide synthes, right?

[00:18:47]With the calcium and then the ATP issues. All this stuff like all of this comes into play. That's why this is important to understand biology. This is a little more of a clever pharmacology, but calcium isn't just about blood vessels. It's about everything. Muscle contraction, neural firing, hormone release, bone momentum, cellular energy production. So when this this is stupid, it pisses me off. When you chronically block calcium channels, you're disrupting one of the most fundamental ions in your biology. 2011 circulation showed calcium channel blockers increase your risk of gingible hyperplasia. Your gums literally grow abnormally because you're disrupting calcium homeostasis in epithelial tissues. You know where?

[00:19:24]Everywhere. 2003 American Journal of Hypertension showed that long-term calcium channel blocker use and massively increased cancer rates, specifically breast cancer in women.

[00:19:34]Huh? How about this one? 2017 study in the Lancet. Again, the Lancet, huh? All these peer-reviewed journals and yet people go, "Your research isn't real."

[00:19:42]Yes, it is. Manurine studies are manufactured so you can get the treatment and you can get the protocol.

[00:19:47]I don't get it how people haven't figured that out. But here's your sign.

[00:19:50]2017 study in the Lancet followed 19,000 patients in on all kinds of anti-hypertensives. And the conclusion watch long-term blood pressure reduction with these drugs. This is nuts. You're going to this going to make you crazy.

[00:20:02]Does not prevent cardiovascular disease in any patients. None. None of them.

[00:20:06]They lower the number, but they don't prevent heart attacks or strokes in people that haven't had them yet. It's not a side effect. It's a failure. That is a fundamental catastrophic failure of the entire paradigm and you guys are spoon feeding yourselves and you're elderly thinking you're helping. Look at 2017 the American Heart Association changed the definition of hypertension from 140 over 90 to 120 over 80. Are you out of your mind? So for 40 years 40 years 140 over 90 was the threshold. It was based on decades of longitudinal data showing that cardiovascular risk increased substantially above this number. 27 rule 2017 rolls around these new guidelines drop. 140 over 90 is now called stage 2 hypertension. 130 to 139 over 89 is now stage 1 and anything above 120 the systolic right diastolic is the second number is called elevated.

[00:20:52]Overnight millions of people went from normal to hypertensive without their blood pressure changing one bit. Do you understand what this means? A single redefinition turned healthy people into patients like this. The study they cited was the sprint study. Okay. The systolic blood pressure intervention trial published in 2015 in New England Journal of Medicine. Here's what Sprint actually showed. Let me help you. In high-risk patients, these are people with existing massive cardiovascular disease, diabetes, chronic kidney disease, targeting systolic blood pressure below 120, reduced cardiovascular events.

[00:21:23]These people were already at risk. But look at the details they never advertised to anybody. First, this was only in high-risisk populations, not healthy people. Second, the absolute risk reduction was 1.5 events per 100 patient years. Tiny microscopic. For every 67 people you treat intensively, you prevent one cardiovascular event per year. Third, and they don't really even talk about this. They don't like it. The intensive treatment group had significantly more adverse reactions and events from low blood from low blood pressure. Syncopy, acute kidney injury.

[00:21:52]You need pressure for your kidneys to function. Did you know that? No.

[00:21:55]Electrolyte abnormalities. People were getting hurt. They were getting hurt.

[00:21:58]But the American Heart Association used one study in high-risisk patients to redefine normal blood pressure for the entire population of the planet. And here's the research they didn't site.

[00:22:09]2016 JAMA by Kaiser Permanente of all places analyzing 1.3 million patients showed that the lowest cardiovascular event rate occurred in patients with blood pressure between 130 and 139 in 89. Yeah, the exact zone that they now call stage 1 hypertension. 2012 study the journal of the American College of Cardiology showed a J-shaped curve for blood pressure and mortality. So you need to understand this. Let me explain it. Below 120 systolic, the first number, mortality risk increases again.

[00:22:42]So now you're too low. Your body needs a certain amount of pressure for proper profusion. You think God doesn't know what he's doing when he designed your ass? Here's the most damning one about this entire thing. 2018 study in the Lancet again showed that people without prior cardiovascular disease, blood pressure up to 150 over 100, not associated with any increased cardiovascular mortality. Nothing. 150 systolic, 100 diastolic, not associated with increased mortality. You want to let that land for a second? So the original threshold 140 over 90, that was actually right. The physiology supported it, but it wasn't profitable enough. So they changed the damn definition.

[00:23:18]Pharmaceutical companies have made an estimated an additional 8 billion with a B in the first 3 years after that guideline change. Millions of new patients all diagnosed without their biology changing whatsoever. This isn't medicine. This is marketing. It's a business model. And they are taking you down and you guys spoon feed yourselves every day thinking this guy doesn't know what he's talking about. If I don't know what I'm talking about, why am I being censored? Here's a question that should terrify you. When was the last time a doctor explained to you why your blood pressure is high? They ever do that? Did he say your endothelium is inflamed and can't produce nitric oxide? Did he do that? Did he say your mitochondria are failing and your vascular cells can't relax? Did he say your kidneys aren't getting enough profusion, so they're releasing rean to keep you alive? No.

[00:23:58]No, he didn't. He said your blood pressure is high. Here's a magic pill.

[00:24:01]Blood pressure is a symptom. Your body's response to an underlying problem. You have to understand that. Think about fever, right? Fever is the symptom of infection. Your body raises temperature to kill pathogens. When we give someone acetaminophen, we lower their fever. We feel better, but the infection is still there. Has it gone away? No. You've massed the symptom without addressing the cause. This is exactly what you're doing with hypertension. Your body raises blood pressure because your endothelial cells aren't producing enough nitric oxide. Your vessels are inflamed and can't dilate. Your blood is too thick from sodium retention and plasma volume expansion. Your vascular smooth muscle cells are too tired to relax because mitochondria are going tits up. And your kidneys aren't getting enough oxygen, so they're releasing rein to maintain their own profusion. High blood pressure is your biology compensating for all of these problems.

[00:24:46]It's like trying to it's fighting this battle that everybody's fighting against. It's doing it to save your life. It's trying to maintain adequate profusion despite the dysfunction. When you lower pressure, okay, listen. I need you to take this seriously because I love you enough to tell you the truth and get irritated when you don't listen.

[00:25:00]When you lower your pressure, your blood pressure with medication without fixing these underlying issues, you're like someone who puts duct tape over something on their car because they don't want to see it and wonders why their car breaks down. The disease is the endothelial dysfunction, the mitochondrial failure, the systemic inflammation, the insulin resistance, the hypertension is how your body is managing it. So here's what this means.

[00:25:23]If you have elevated pressure but normal endothelial function, normal vascular inflammation, normal mitochondrial function, and you have normal insulin sensitivity, listen. So, if you have elevated pressure, I'll say it again, and your endothelial function, your vascular inflammation, your mitochondrial function, your insulin sensitivity, those are all normal.

[00:25:39]There's nothing bad. There's nothing elevated. CRP, glucose, insulin, all of it, homir, all of it is like it's all perfect. Meaning, you've measured these things. You've looked at labs. Then elevated blood pressure is not pathological. Period. But how many of you doctors listening to this are measuring endothelial function? How many of you guys are doing it? How many are measuring mitochondrial ATP production capacity? Huh? How many testing insulin sensitivity? Anyone? No. You guys use your HBA1C, which is a ridiculous number. It's a 3-month average of garbage. You use HOM IR and you can actually see the picture, but nope. Not doing that. Nobody is doing what I'm telling you to do. They're treating a number while ignoring the freaking disease. How about this? This infuriates me because I see some people like oxygenarians I are my favorite people because they've got a lot of life and I love asking questions and they can't be bought for the most part. Oxygenarians are people over 80 if you don't know that. So here this Franken infuriates me so bad. Brandy and I were just talking about this. Bry's my wife. Modern guidelines. Okay. This just makes me fury just fuming. They treat blood pressure as this universal number. Get to 120 over 80 or you're going to die. I don't know all you med students making reaction videos to me because I'm incredibly intelligent compared to you because I actually pay attention to biology and try and solve problems, not brag about my diploma. Physiology doesn't work like that. It doesn't work like that at all. Look at the Invest trial from 2003 published in the Journal of the American Medical Association or the HOT study from 1998 in the Lancet.

[00:27:04]Both showed something called the Jcurve effect. It's a U-shaped relationship between blood pressure and mortality. So here I'll give you the basic translation. If your pressure is too low, your your mortality goes up. You die. Why? Because if you have stiffened arteries from decades of aging, your vessels have calcified. If your endothelium has sustained decades of oxidative damage, I don't know. Your pressure of 150 systolic might be the necessary hydraulic force to push blood to your feet, your brain, and your kidneys. You force that down to a buck 10 with chemistry. You are creating, you are manufacturing systemic hypoxia. Your tissues aren't getting enough oxygen anymore to what did I say? Your feet, your brain, and your kidneys. So now you're dizzy. You're being diagnosed with dementia. You have renal failure, and you have neuropathy. But none of it is. It's manufactured. It's because of a drug. So look, for a 60-year-old with calcified vessels, 150, and I didn't even go to the oxygenarian. 150 might be necessary. That's compensatory physiology. That is wisdom that your body has. It is your biology keeping your butt alive and we're lowering it with a drug. 2009 circulation showed that in elderly patients with hypertension and evidence of arterial stiffness, aggressive blood pressure lowering, increased cardiovascular event rates because you've crossed the J curve. You lowered pressure below what was necessary for adequate tissue profusion. This is why we see something called treatmentinduced hypotension adverse events. But bet you guys never even heard of that, huh? very real, very documented, and it's almost never discussed. So, your 75-year-old grandmother who's done everything right entire life, who's got rigid, calcified vessels from aging, might legitimately need 150 over 90 to keep everything working. But the guidelines, those frigin guidelines say that you should be on three medications to get them down to a buck 20 over 80. That's not medicine.

[00:28:52]I'll say it again, that's a business.

[00:28:55]Big pharma has built this castle on dozens of claims, but five big ones that hypertension causes stroke, heart attack, kidney disease, heart failure, and cognitive decline. So, I'm going to help you. I'm going to dismantle the crap out of all of them. So, look at hypertension causes stroke. The fear-based sales pitch that gets people taking pills, baby. I'm going to need coffee for this one. 2013 study in stroke by the American Heart Association analyzing 65 years I'll say that number again 65 years of epidemiological data showed something very interesting there is a relationship between hypertension and stroke but the relationship is entirely mediated through atherosclerosis endothelial dysfunction and arterial stiffness. Huh? So let me explain what that means means it's not the blood pressure causing the stroke.

[00:29:37]It's the underlying vascular disease causing both the hypertension and the stroke. You know what that you know what hypertension is? It's a marker of the disease, not the cause. But nobody's dismantling any of this stuff. You just, oh, okay, I'll just take this pill. 2016 hypertension back showed that patients with hypertension who had normal endothelial function and no atheroscllerotic disease, stroke risk virtually identical to normotensive people. The variable that predicted stroke, arterial stiffness, endothelial dysfunction, inflammation, not blood.

[00:30:05]Yet we treat blood pressure while ignoring endothelial dysfunction. How about this one? Hypertension causes heart attack. That's my favorite. Okay.

[00:30:13]2014 meta analysis JAMA showed that the relationship between blood pressure and an MIAL inffection is mediated by aththeroscllerotic disease progression.

[00:30:21]Again, hypertension is the marker, not the cause. Weird. So, it gets even better because this is the stuff that gets me just gritty. 2011 study in circulation showed that among patients with hypertension who achieved controlled blood pressure below 140 over 90 if they had elevated inflammation markers elevated oxidative stress and elevated endothelial dysfunction markers their MI risk their moardial inffection risk still remained high didn't change controlling the blood pressure number didn't change the risk one bit because you hadn't addressed the inflammation causing the atherosclerosis I talked about this already right the plaquing the foam cells the macroofagages chewing them up all this stuff the fi the metal protein, the proteinas, all this stuff that comes into play here. How about this? Hypertension causes kidney disease. Okay, I'll give you that one.

[00:31:04]Severe hypertension absolutely can damage your kidneys. Absolutely. The glomemeilus, super sensitive, and that little tuft of vessels, but we're talking a buck 80 over a buck 10 consistently. Consistently. Not when you're scared out of your mind cuz your brother pops out of the closet. But 2015, Kidney International showed that mild to moderate hypertension does not cause progressive kidney disease in the absence of protein ura and reduced eGFR, glomemeular filtration rate. If your kidneys are functioning fine and you're not spilling protein into your urine, your elevated blood pressure, it's not damaging your kidneys, son. In fact, here's something they're never going to advertise. 2012 study, New England Journal of Medicine showed that aggressive blood pressure lowering lowering in patients with chronic kidney disease without diabetes actually worsened renal outcomes. Your kidneys need adequate pressure to filter properly. I told you this earlier. If you drop it too low, you actually impair function. How about this? Hypertension causes heart failure. Okay, I'll give you this. It's got some truth. The chronic hemodynamic stress from elevated pressure can lead to left ventricular hypertrophy, which then leads to dysfunction. But here's the nuance to this beautiful apple that you're about to eat. 20 Yeah, Satan, the Garden of Eden, if you don't get the reference, 2017 European Heart Journal showed that heart failure outcomes in hypertensive patients, primarily determined by systemic inflammation status, oxidative stress markers, and myioardial fibrosis, not by the blood pressure itself. So patients with hypertension, but low inflammation, normal oxidative stress, and normal myioardial structure, heart failure risk didn't budge. Didn't budge.

[00:32:39]In patients with controlled blood pressure but high inflammation and evidence of fibrosis, heart failure risk significantly elevated. Again, treating the symptom, not the disease. And people like, "Where's your research? I've got stacks of this baby." How about this one? Hypertension causes cognitive decline and dementia, vascular dementia.

[00:32:58]Right. Bruce Willis. I am so He stresses me out because I don't know him at all, but just want to This is the most recent panic point. That's the problem.

[00:33:06]It's almost egregiously oversimplified.

[00:33:08]Just to be very clear, 2016 study in neurology showed that blood pressure is related to cognitive decline. But when they controlled for inflammatory markers endothelial dysfunction and cerebrovascular disease, the relationship largely vanished. Here's gets even better. 2018 study in neuro neurobiology of aging. The populations with the highest hypertension rates, those consuming processed foods, the omega6, right? refined carbs, sitting on their butt, denting their couch, sedentary, high systemic inflammation, obese. You know what else they have? The highest dementia risk on the planet. The shared cause isn't hypertension, you guys. It's the dietary and lifestyle factors causing systemic inflammation, endothelial dysfunction, atherosclerosis, and hypertension as a symptom. 2017 longitudinal study in the American Journal of Clinical Nutrition followed 5,000 subjects for 15 years. That's a long study. Subjects with hypertension who consumed high quality diets with adequate antioxidants and anti-inflammatory nutrients showed no increased dementia, no risk, nothing compared to normal intensive controls.

[00:34:10]Nothing. Zero. The blood pressure number was completely irrelevant. Nutritional status is everything. But nobody's talking to you about that, are they?

[00:34:15]Look, here's what you actually do. Let's just get right to the meat and potatoes on this guy. It's I'll just put a bow on this and land. Stop thinking of this as a blood pressure problem. Start thinking of this as a metabolic and vascular disease problem. Please, what do you got to lose, man? What do you got to lose?

[00:34:29]Look at fix insulin sensitivity. This is the foundation. Everything else depends on this. Eliminate refined carbs.

[00:34:34]Eliminate seed oils. They're inflammatory omega-6 nuclear bombs inside you. Eat whole foods, grass-fed meat, wild fish. Throw some berries in there. 2017 study Jamba showed Mediterranean diet reduced blood pressure by 10 millimeters of mercury.

[00:34:48]On average, by the way, on average, it also restored insulin sensitivity, reduced systemic inflammation, improved endothelial function. You're not just lowering a number. You know what you're doing when you do that? You're reversing a disease. And it didn't. The problem is you're not profitable like that. So why would they're just going to bury it, right? It's like when you're digging for water and the you start you you're making a well, the water shows up. Oh, got to bury this. We need a couple more days of work. That's the logic right now. Restore. You have to restore your mitochondrial function. Your cells need energy to function. You need ATP. That energy comes from mitochondria.

[00:35:14]Exercise, resistance training. Okay? Not just getting up and down out of your chair, sit and be fit was cute, but you can do more than that. I'm talking resistance training. High-intensity intervals. It stimulates mitochondrial biogenesis. 2016 meta analysis. Sports medicine showed that it just 20 minutes 20 minutes of resistance training three times a week increases nad plus availability and ATP production which improves vascular smooth muscle relaxation reduces blood pressure by 3 to 5 millm of mercury because your vascular system improves you don't have 20 minutes three times a week put down the muffin get up look at aerobic exercise 2018 study circulation I'll go I'll go both sides of this equation for you consistent aerobic activity 30 minutes every Every day. Yeah, every day. I train every day. Increases mitochondrial volume by 40%. Improves endothelial function more profoundly than any drug ever made. Fix the endothelial dysfunction. Your endothelium needs specific nutrients and conditions to produce nitric oxide.

[00:36:14]Right? So, get your vitamin D up over 50. 2018 meta analysis and circulation showed that vitamin D directly activates enos. So for every 10 increase in vitamin D, systolic blood pressure decreased approximately 4 millig or millimeters of mercury. You do understand how huge that is across the deficient to sufficient range, right?

[00:36:33]Get adequate magnesium 600 milligrams every day. Magnesium is required for ENOS function acts as a natural calcium channel blocker. 2016 meta analysis and nutrients analyzing 34 random randomized control trials. 34. It's not 34 people.

[00:36:47]These are 34 trials showed that magnesium supplementation reduced systolic blood pressure. High five. Get adequate potassium. Populations with the highest potassium intake and lowest sodium intake, by the way, have the lowest hypertension rates. No, sodium does not cause hypertension. 2017 systemic review in the American Journal of Hypertension showed that potassium supplementation reduces systolic blood pressure by five on average. Eat nitrater foods, beef or beets, leafy greens. Your body converts dietary nitrates to nitric oxide. Yeah, I I don't know what to tell you. It beet juice, single glass of beet juice reduced systolic blood pressure by eight. They saw this by 8 millimeters of mercury. This was in 2015 randomized control trial hypertension at Queen Mary University in London. They should one glass. This stuff isn't hard. You got to reduce systemic inflammation. This one's the killer all the time. Get rid of all your processed foods. You got to stop doing that to yourself. It's Why would you do that to yourself? Right? All I hear is that's what she said. If you've never seen man with a plan, you have no idea what I'm talking about. So get rid of seed oils, processed foods. All they do is create oxidative stress and inflammation. Add omega-3s, right? Four grams every day. Precursors to resolins.

[00:37:49]I talked about this the other day. Bunch of lipid mediators. They just actively resolve your inflammation. Add polyphenols, berries, green tea. I I always hate saying this one because you guys take it and run with it. Dark chocolate, right? Go ahead. Incredible antioxidants. Reduce oxidative stress and improve endothelial function. It's not This stuff isn't compliment. It's not complicated. You got to shut down your stress. Optimize your sleep. Get some rest. I don't care how much sleep you need. Just make sure you're getting it. That's all. Chronic stress cranks up cortisol and catakolamines which activates the renan edotensin eldoststerone system. It completely inappropriately by the way. So poor sleep does the same thing. So 2015 study hypertension showed that improving sleep getting quality sleep every night reduced blood pressure by 5 millimeters of mercury on average. Five. Five is big. Just so you know if you're like it's just five. It's enough. Decide what you need to do. Okay. Here's what infuriates me. The physiology is elegant. Your body is it's intelligently compensating for broken internal terrain by raising blood pressure to maintain organ profusion. Agreed. When you fix the internal terrain, I'll help you.

[00:38:52]Insulin sensitivity, mitochondrial function, endothelial health, inflammatory status, blood pressure normalizes naturally. There are no side effects except you get healthier in every possible way. Fixing it takes work. People don't like that word. It takes discipline. It takes a person willing to change their diet and start exercising and manage stress, fix their sleep, get their life in order. That's no there's no recurring revenue in that.

[00:39:14]No quarterly earnings calls, no patent protected chemistry. So instead, you know what big pharma does? Offers a simple solution. A pill that lowers the the number while leaving the disease untouched. So a doctor, look at this, this is aggravates me so bad. I talked about this yesterday. Doctor checks your blood pressure. It's a buck 45 over 92.

[00:39:31]And then hands you a prescription for a beta blocker and says you have essential hypertension. Notice the word essential like it's fundamental to you you being there being alive like you're broken at the cellular level like you need chemistry to be normal. You take the pill, the number drops to buck 25 over 80. You feel like you're being treated.

[00:39:48]You feel safe. You're like this is awesome. Your biology is still broken.

[00:39:51]It's still screaming. It's still broken.

[00:39:53]Systemic inflammation is still there. It doesn't solve it. Your endothelium is still dysfunctional. Your mitochondria are gone. Your insulin resistance is still destroying all your tissues. How does that even make sense? But now you're on a medication that makes all of those things worse. The beta blocker increases insulin resistance, proven.

[00:40:07]Suppresses sympathetic nervous nervous system activation, so your tissues don't get adequate oxygen when they need it.

[00:40:12]Increases depression and sexual dysfunction. So, you gradually get worse. Your energy tanks, your metabolism tanks, your cardiovascular disease progresses silently in the background like a sniper. Then 5 years later, you have a heart attack. And the doctor says, "Your blood pressure was controlled, but clearly the medication wasn't enough. Let's add a second drug."

[00:40:29]You slowly die, believing that you were being treated for something that doesn't need to be treated.

[00:40:34]I'm trying to help you. Here's what you need to understand. It's deeper than your rational mind. Hypertension is not a disease. Okay? I'm going say it again and again. It is not a disease. It's a symptom. It is bi biology screening that something is broken in your internal terrain. The doctor is treating pressure. I'm teaching you to treat the freaking human. Insulin sensitivity, mitochondrial function, endothelial health, your systemic inflammation.

[00:40:55]These are all variables. They're the ones that matter. That's what matters.

[00:40:58]That's what's causing the problem. Blood pressure is the readout. It's the dash light that's telling you something's wrong under the hood of your car. It's when the check engine light comes on in your Porsche, right? Everybody's busy treating the freaking light. I'm trying to tell you how to fix the engine. Like I said, listen to me or don't listen to me at this point. I don't really care.

[00:41:13]You You have to do what you It's not up to me to choose health for you. It's up to you. Hey, look at 2016 study. Journal of Journal of American College of Cardiology followed 1500 hypertensive patients through comprehensive lifestyle. Just lifestyle, nothing else.

[00:41:25]Lifestyle intervention. Average blood pressure reduction 18 over 11 reduced.

[00:41:30]Okay, you know what that is? Drug level effects. Except they actually improved every other aspect too. No side effects, no depression, no systemic dysfunction, no sexual dysfunction, no metabolic destruction, no grenades going off in their system biologically. Just better.

[00:41:46]Just better. Listen, I feel I gave you a pretty good macro level understanding of what hypertension is and why it exists, right? So, let me give you the actual protocol that reverses it at the cellular level for your kangaroo. I just need you guys to understand GHKCU. Okay, I'll just give it to you. It's a co-actor for something called lysol oxidase. It's the enzyme that cross links collagen and elastin in your arter arteries. Remember what I said about the aorta? How it has to stretch and come and snap back into place. So when your vessels are inflamed and damaged from years of oxidative stress, they lose their structural integrity. They become very stiff, very calcified, and they can't dilate. Copper does something phenomenal. It binds to copper and stimulates all these collagen synthesis pathways. 2013 study in plus one showed GHKCU increases type one and type type one and type three collagen production 400%.

[00:42:32]I'm not talking some weird scar tissue.

[00:42:34]I'm talking solving the problems. It also upregulates HIF-1 alpha which is hypoxia inducible factor. Hif1 alpha tells your cells just to help you out.

[00:42:44]We need better vascular function activate angioenesis improve all the microirculation the small stuff. So for hypertension 2015 study of vascular medicine showed that GHKCU improves endothelial function, reduces arterial stiffness by remodeling the extracellular matrix and vessel walls.

[00:43:01]So you regain elasticity. Now they can dilate and function and resistance decreases and pressure normalizes and your system runs perfectly. That's just the first thing. Look at NAD+. It's the currency of your it's the energy currency, right? Your mitochondria.

[00:43:12]Remember failure three, right?

[00:43:14]Mitochondrial dysfunction and ATP depletion. NAD+ is the substrate for cert 3. Certain if do you know what they do? They activate mitochondrial repair and biogenesis. So when NA NAD+ is depleted which happens from aging and metabolic dysfunction and bad decisions and oxidative distri o oxidative stress your mitochondria can't produce enough ATP. Your cells can't relax and your vessels stay constricted. Okay. 2017 study nature metabolism by Lopez Luch showed NAD+ levels are 50% lower in hypertensive patients compared to the controls. Their mitochondria are literally energy starved. 25 milligrams.

[00:43:48]Ah, I always hate doing this for your kangaroo. 25 milligrams NAD+ every day.

[00:43:52]Subq restores mitochondrial function.

[00:43:54]I'll just leave it at that. Your vascular smooth muscles. The cells now have the energy to relax. Now they can do their job. Calcium pumps work.

[00:44:00]Remember what I talked about with calcium vessels dilate. Resistance drops. BPC, the one that everybody's freaking out about right now. 750 micrograms two times a day. Okay. BPC 15 amino acid peptide. This thing is so gangster. And every insta expert out there with chat GPT is talking about it like they know anything about it. It aggravates me because they're giving you misinformation. And then there's a muppet somewhere that goes on some podcast and starts telling you that it causes cancer and it's untested and unstudied and there's no research and all I want to do is go, "F, you're a liar. You've been bought. You can't buy me." That's why I'm out here telling you the truth. Love me or hate me, I really don't care. I'm a gritty, grumpy old doctor that just wants you to be strong as a bear. You decide what to do with the information. It's not up to me. So here's the mechanism for hypertension. I need to tell you this BPC it upregulates something called vascular endothelial growth factor BEGF 2016 study journal of translational medicine. It showed BPC57 stimulates new blood blood vessels and improves microirculation. Okay, but here's the deeper effect. This is important. I and you got to understand this. And if you don't understand biology, I get a lot of people going how do I learn all this? I don't know. Spent 30 years reading biology and 40 actually and understanding what goes on because I've been a biology biochemistry science nerd my whole life. It's just awesome. I love this stuff. So, it also protects and repairs the endothelial glycoalix.

[00:45:16]It's this. So, let me explain. It's this protective layer that it coats your endothelium. When this layer is damaged from oxidative stress or inflammation, especially endothelial dysfunction, skyrockets, BPC regenerates it. 2019 cardiovascular research showed that it increases nitric oxide production by 40%. Specifically through glycoalix repair. Huh. Where's a BP med that does that? I just I'm waiting. Is there a calcium channel blocker or maybe an ACE inhibitor that does that? I don't know.

[00:45:44]You tell me. No. No. Weird. Also has heprotective effects, too, by the way.

[00:45:48]Liver, your liver produces angotensinogen. A dysfunctional inflamed liver produces more of it. You know what BPC does? Improves the liver detox pathway and reduces systemic inflammation. Call me crazy, but I'm just out here giving you stuff for free cuz I care. I don't care if you buy it from me. Go buy it from someone else if you want to. Doesn't matter to me. I would say that's stupid, but you do you, boo. Glutathione. We know what this is.

[00:46:11]It's like your defense against oxidative stress and the reactive oxygen species that causes, if you remember earlier, go back about 40 minutes, endothelial nitric oxide synthes uncoupling, the enos uncoupling, remember uncouples and it makes super oxide instead causes all kinds of problems particularly demolishes your system atherosclerosis all of it. So you remember so it it causes the tetrahydropholate co-actor that enos needs. It oxidizes that. I don't know if you remember that if not I'm reminding you. Glutathione prevents that. 2014 study, vascular pharmacology showed that glutathione increases intracellular antioxidant capacity and restores enos coupling. So it actually solves the problem. It doesn't just prevent it, it solves it. Coupled enos produces nitric oxide. Uncoupled enos produces super oxide. When adequate glutathione liver, your enos stays coupled. Nitric oxide production increases 40%. Vessels relax. Pressure drops. Plus glutathione reduces systemic inflammation. 2017 study, Redux Biology showed glutathione depletion correlates with TNF alpha and IL6 elevation.

[00:47:09]Restore glutathione and the inflammatory cytoines go bye-bye. KPV subq always. By the way, enough with these orals. Orals don't work. I don't know how many times I got to tell you, stop arguing with me.

[00:47:19]I'm trying to help you and you guys are in the comments arguing because you just don't like being wrong. It's like the world has this necessa.

[00:47:27]You got to just go and argue for the sake of arguing because you don't want to be wrong. I'm wrong all the time. I'm just not wrong when I talk about biology. So just I'm trying to help you.

[00:47:36]KPV 500 micrograms twice a day. You can go 400, but 500 is just a nice easy number, right? Here's why it matters for hypertension. By the way, KPB inhibits mass cell degranulation and macroofage activation. Okay, so macrophagages, remember what I talked about foam cells.

[00:47:49]Okay, so when your when your biology is systemically inflamed, mass cells are releasing histamine and inflammatory mediators that activate the RAS, reanotensin aldoststerone system. Okay.

[00:48:00]So, KPB silences this. 2015 plus one showed KPV reduces TNF alpha and IL6 production 70% in inflammatory conditions. Oh, it does better. It protects the intestinal barrier. 2018 study in gut showed that KPV enhances tight junction proteins. Prevents intestinal permeability. Leaky gut the s which is pretty much the source of systemic inflammation and metabolic dysfunction. So, watch. Less intestinal permeability, less systemic inflammation, less RAS activation, lower blood pressure. How about M C? Yeah, I've got two I've got multiple protocols for MOS before you guys go, what protocol should I use? The one I give you for this. That's the problem, right?

[00:48:35]You guys are like, I started doing it this way. I even get people coming to my group. I just thought it would be good to add it, so I added it. I get messages from you guys if you're listening all the time. Hey, I thought this I watched your podcast. I think it would be really good to add. Can I add it? I I started already. No. You know why? Cuz your biology can't keep up. That's why I'm trying to help you. It's a peptides and drugs are not the same. Peptides demand of your biology. drugs go. I don't care if your biology can keep up or not. I'm making you do it and I'm doing it at your expense. Not the same. Not the same. Mi 5 milligrams for your kangaroo every four days. Mi activates AMPK am activated protein kinus, which is the energy switch, right? Here's what it does. Let me explain this because I want to I'm hungry. I want to go inside, but I I want I need to help you guys. And I want you guys to solve your hypertension. And it is the most mis represented lie on the planet. This and statins. And I see people that I used to consider friends of mine that were giving statins to friends of mine. And I'm like, you're an idiot. Like you're harming people. And the indoctrination is very strong. So look, AMPK, the activation does a couple of things.

[00:49:41]Increases insulin sensitivity massively directly addressing failure. One. Let's just go through my failures, right?

[00:49:46]stimulates bio mitochondrial biogenesis which addresses failure three and reduces systemic inflammation directly addressing the RAAS dysfunction 2015 study cell metabolism by Lee showed Matsi administration improved insulin sensitivity by 40% and reduced metabolic syndrome markers by 50%. You ready for this? Two weeks. Two weeks. That's why I talked about Reddit Tide and Matsi for insulin sensitivity. You have to do it right though when people like oh I'm just going to take those two. It's going to be great. You're going to go out and eat at McDonald's. I got nothing for you. For blood pressure specifically, improved insulin sensitivity means the kidneys stop retaining sodium. So now, if you remember, your plasma volume is going to drop. It's going to normalize.

[00:50:23]Blood viscosity decreases. It's not syrup anymore. And the P13K pathway reactivates, which allows insulin to signal enos to produce nitric oxide. You see how this is all connected? Magnesium glycinate, 500 mg every single day. Take it at night. And yes, it can sometimes upset your stomach. In that case, use transmal instead. There's a couple of really good ones. It's one of the few I I will tell you to use. It's awesome.

[00:50:44]Put it on the joint that hurts. It's even better. So, I've talked about magnesium adnauseium, but it's required for ENOS function and acts as a natural calcium channel blocker. But glycinate form is critical. This is important.

[00:50:54]Glycine itself is inhibitory to the nervous system. So, it calms while magnesium restores vascular function.

[00:50:59]Zincolonate 30 milligs daily. Now, there's an issue with the relationship between copper and zinc, but you can bypass that with subq copper so they don't compete, right? That you need that 10 to1 ratio zinc to copper because they compete in the gut. So zinc is a co-actor for superoxide dismutase. It's your primary mitochondrial antioxidant enzyme. Low zinc means inadequate superoxide dismut dismutase activity. So here's what happens. Super oxide accumulates. Remember what that was from? Which means enos uncoupling. You see where this is going? You see how this is all connected. 2016 hypertension showed zinc deficient subjects 60% lower superoxide dismutase activity and significantly elevated blood pressure.

[00:51:36]Restore zinc. Super oxide dismutase activity increases oxidative stress stops and enos couples properly. Omega-3 I love this stuff. I take four grams every day. I split it into a couple of doses throughout the day. EPA and DHA are precursors for resolvance and protectants. I went over this the other day too. These they're lipid mediators that actively resolve inflammation. They incorporate into cell membranes, improve fluidity. They're just phenomenal. You need them to survive. Okay. And no, you can't. Flax is not going to help you.

[00:52:01]Fish oil 2019 and somebody's going to get in my oh there's a research study.

[00:52:04]Then you do that. I you don't need to show me the research for what you're doing. I don't give a crap what you're doing. I'm trying to give you a solution that actually works. You want to do whatever you want. You do you, boo. So, 2019 meta, yes, I'm a doctor that says that 2019 meta analysis in JAMA showed four grams daily omega-3 reduces blood pressure by 5 millimeters of mercury.

[00:52:22]And more importantly, it gets even better. Reduces systemic inflammation markers by 40 40%. You guys do get that, right? I take this stuff all the time.

[00:52:30]Vitamin D3, 5,000 IU every single day.

[00:52:32]This directly activates ENOS expression.

[00:52:35]also suppresses renan production in your kidneys, downregulating the RAS system.

[00:52:40]Right? You see how this maybe it's just me, but I love connecting this map and going this is that your destination is here all the roads that you need to take to get there. Once you're there, you got it. You've reached your destination.

[00:52:50]Now, just maintain it. 2018 meta analysis circulation showed that vitamin D status inversely correlates with blood pressure. 67 different studies. Optimal D3 level, so that'd be between 50 and 100. Requires 5,000 IU daily for most people. K2 you have to take K2 otherwise you have calcium issues right K2 and D3 you got to take these together 200 micrograms every day K2 activates osteocalin and matrix GLA protein okay proteins the these prevent arterial calcification when your vessels calcify remember what I said they can't do they don't have that elastic capacity they become stiff and resistance in and resistant increases right so K2 prevents this 2015 study in thrombosis and hemat thrombosis and heistasis showed K2 supplementation reduced arterial calcification progression by 70% over 3 years. 70%. What if your bank account went up 70% over the next 3 years? And if you go, I only have five bucks. Get busy. Potassium 3 g every day. So the sodium potassium pump is the primary active transport mechanism in all of your cells. Requires ATP and direct potassium availability. When you are potassium deficient, which is why things by the way that they use as well, I just thought about this, they use this as well for hypertension. Lasix. Lasix ferosomide. Lasix is a loop diuretic, which means it forces you to excrete about 50% of the filtered load. So 50% of what goes through gets pulled out.

[00:54:10]What do you think that's doing to your electrolyte balance in your blood and your blood viscosity? So is it actually solving hypertension to help you out?

[00:54:18]No, it's not. And they usually require something called slow K, which is a potassium supplement because it's and if they go potassium sparing, not enough.

[00:54:25]So here's the issue. When your potassium, you see how this is all a massive problem. This makes me so irritated. The kidney when you are potassium deficient, the kidneys think there is a sodium deficit and retain it.

[00:54:36]Plasma volume expands, blood pressure rises. So they give you Lasix. Just use this one. They give you Lasix. It's It depletes potassium. Plasma volume expands, blood pressure rises. They increase your dose of Lasix or give you an ACE inhibitor instead or give you both. Yeah. Are you seeing problem? Are you checking off problem boxes? You know what else potassium does? Activates a P13K pathway that tells your endothelium to produce this awesome stuff called nitric oxide. 2017 systematic review American Journal of Hypertension showed potassium supplementation reduces systolic blood pressure by 5 millimeters of mercury on average. Ubiquinol 200 milligrams every day. Ubiquinol is a reduced form of CoQ10. It's you need it for the electron transport chain to even function properly. Mitochondria can't produce ATP efficiently without it.

[00:55:18]Period. 2015 meta analysis journal of human hyper and journal of human hypertension showed that ubiquininal supplementation reduces systolic blood pressure 5 millm of mercury. So you're getting all these adding up, right?

[00:55:28]Solves some ATP, mitochondrial ATP production problem and vascular smooth muscle cell energy crisis. Carnivore diet. People hear this. Oh, I couldn't do that. It's really hard for me. Let me help you do the diet if you have hypertension. Carnivore diet. So meat, organs, salt, water eliminates all the inflammatory triggers causing systemic inflammation and endothelial dysfunction. Period. Period. It's not that hard. Just so you know, 2020 observational study in nutrients tracking 2,000 carnivore dieters showed 87% experienced significant blood pressure reduction within 12 weeks, averaging a drop of 22 over 14.

[00:55:59]Systolic, diastolic, water. You guys aren't, you guys need to schedule your water. Most of you guys aren't drinking enough water. Four lers of water every day. Use an LMT packet. I'm tired of these people going, "I don't use LMT. I get this cuz it's cheaper." Why would you ever want to be cheap with your biology? That's the last thing I'm going to be cheap with is my biology cuz it allows me to do everything else. You guys need to think of what you're doing.

[00:56:18]You will spend absolutely ridiculous amounts of money on a car or clothes or whatever it is you're whatever you're doing, but you won't do it for the thing that allows you to enjoy the car or wear the clothes. I don't know what to say.

[00:56:30]LMT just sodium, potassium, magnesium in the proper ratios. The protocol is this.

[00:56:34]Four liters of water every day. One LMT packet. So, it's 500 milligrams of sodium, 200 milligs of potassium, and 60 milligs of magnesium every day. It's all you got to do this. Listen, your kidneys regulate blood pressure partially through plasma osmalerity. So when you're dehydrated or you have improper electrolyte ratios, which I was explaining earlier, your biology retains sodium to maintain the osmotic balance.

[00:56:55]Sodium follows water into the intravascular space. Plasma volume increases. Blood pressure skyrockets.

[00:57:01]But here's a nuance. You can't just drink water. Pure water without electrolytes dilutes your blood sodium concentration, triggering ADH, antidiuretic hormone release, which then causes your kidneys to retain more sodium and water. You need proper electrolyte ratios. Sodium expands plasma volume, potassium, magnesium, balance sodium, and support vascular relaxation. Throw a mile walk in there.

[00:57:22]Low intensity, easy pace, right? One mile at a 17-minute pace. That's about it. Turns on AMPK. Stimulates mitochondrial biogenesis without creating any excessive oxidative stress.

[00:57:32]So look, walking is anti-inflammatory.

[00:57:34]2015 study, Journal of Applied Physiology showed regular walking reduced TNF alpha and isle 6 by 30% in 6 weeks. You're just going for a walk.

[00:57:44]That's it. My parents used to walk four miles almost every day. I'd watch them.

[00:57:47]It was one block. I lived out in the cuts in the country. One block was four miles. Each road was a mile. So they would walk and I'd see my dad's yellow windbreaker through the kitchen window.

[00:57:55]I'd see him way the hell far away across the field.

[00:57:57]>> Right.

[00:57:57]>> Lose your visceral fat. Listen, I'm tired of people going, "You should be really nice when people are overweight.

[00:58:03]It's a problem. You're fat. It's killing you. Please stop." I'm saying it because I love you enough to tell you the truth.

[00:58:08]Not you have a little bit of a gravity problem. You're fat. And visceral fat's the one that's killing you. Visceral fat is the fat that surrounds your organs metabolically active. It all is, but this one's severe. It secretes TNF alpha, IO6, a bunch of other inflammatory cytoines directly into your portal circulation. That's the problem.

[00:58:21]This drives systemic inflammation and endotoxmia. It's like having this blowtorrch inside you all the It's a chronic inflammatory wound inside your abdomen that's just puking out cytoines.

[00:58:30]When you lose visceral fat through the carnivore diet and walking, okay, systemic inflammation drops dramatically. 2014 study in obesity showed that 10% reduction in visceral fat decreased TNF alpha by 30% and IL6 by 25%. Endotoxmia decreases less visceral atapos less visceral atapost tissue means less bacterial LPS lipopolyaccharides in the circulation less toll-like TLR4 activation less inflammatory cascade le insulin sensitivity improves visceral atyposity is the strongest predictor of insulin resistance by the way if you didn't know that lose the visceral fat and insulin signal signaling normalizes within weeks like this how about the kidney the raas activation it decreases with less systemic inflammation boy that systemic inflammation's a bugger huh your kidneys You're getting better profusion, endothelial function improves. There's less stimulus for that renan to be released. How about this? I give you some labs, too. Huh? Fasting insulin.

[00:59:22]You need these labs. Just walk, go to Quest or Lab Core or whatever. If you go to your doctor and your doctor won't give you these, it won't do these labs for you. It says, "Why do you want them?" Look them square in the eye. You set your do you set your jaw straight and you go, "You're fired and go get a different doctor." Your doctor should never ever discount what you're telling them if you have a health problem. If that doctor ever tells you not to do it because they have an agenda, I bake a fresh batch of these every day. I'm flipping the bird to the camera if you're wondering what I'm doing. You need fasting insulin, fasting plasma glucose, hemoglobin. You need fasting insulin, fasting plasma glucose, HB1C.

[00:59:56]It's not a great one. Like I said, it's only it's three year a three-month average. Three years, that'd be terrible. Three-month average, but it you need to still have a baseline. Okay.

[01:00:03]APOB, epolippoprotein B, C reactive protein. It's called high sensitivity. C reactive proto HSCP GGGT gamma glutamill transferase magnesium RBC magnesium and serum potassium feritin you can calculate the home IR yourself if it's above one I'm concerned if it's above 1.5 you are definitely drifting into bad territory if it's above two congratulations you are insulin resistant it's a if it's above three you're looking down a 357 magnum of metabolic syndrome that's what you're doing so I don't know I what to tell you stop asking questions take the data go do it when you get some results and solve your problem Here's your choice.

[01:00:38]You can do what you want with this information. You can get my comments and [ __ ] like some of you guys do. Or you can sit there and go, "Thank you so much, Dr. Trevor. You do love us." Yeah, I do. I do. And maybe this is like the prodigal son's going to come home one day and you guys will be like, "You know what? He did care." Yeah, I did. And I still do. So, here's the choice. You can take the easy path and pop these pills once or twice a day and if you're a dude, watch your equipment not work and your wife bang the pool guy. I really don't know what to tell you, but let your doctor be responsible for your health, which I think is absolutely ridiculous. You can feel like you're doing something without actually fixing a damn thing. Right? You can do that. Or you can take the path that requires some work. Change what you eat. Start moving your body. Lose some weight. Manage your stress. Leave properly. Get your nutrients right. Run that protocol that I just gave you. And watch your blood pressure normalize. Watch your energy increase, your cardiovascular health actually improve. And watch your biology, your freaking body heal itself.

[01:01:26]Because that's what happens when you honor physiology instead of get in the ring and start going to war with it.

[01:01:30]Your body wants to be healthy. Your body is not fighting to make you sick. And I'm tired of people saying that. It doesn't do that at all. Your biology in fact is doing the opposite. It's fighting all day long to keep you healthy and strong. You have been conditioned and indoctrinated to think your body always has it out for you. No, it doesn't. No, it you are fat from your decisions. You are stressed from your decisions in your environment. You are living. You are a living product of everything you have done in your life up until right now. And you can change that at any freaking time. Your body wants to thrive. It's been screaming at you with elevated blood pressure for probably years trying to compensate for the broken internal terrain that I keep talking about that I gave you great example and pure guidance for this. You could use this as an owner's manual.

[01:02:06]Give it what it needs and it will reward you with this magic thing called vitality. Stop fighting your biology.

[01:02:11]Please stop. Just start fixing it. The difference between management and cure, right? That's the difference. It's the difference between a life spent taking a bunch of pills and following around a white coat waiting for them to tell you what to do and thriving and living. I know what one I'm choosing because I've been down this road. I'm trying to give it to you for free. By the way, for free. I don't know. The question I think you should ask is which one do you choose? Because the answer to that question is not just going to determine your blood pressure. It determines your whole life. Anyway, I got to go. I want to go inside, see my wife and my kids and that cat. Hope you got something out of this. I got to go.