I Tested Every Fat Loss Peptide, These Will Get You Shredded This Summer (Beginners Guide)

Added: 2026-05-30

[00:00:00]Peptides have changed the fat loss game forever, and most men are still playing by the old rules. These are the 12 most powerful fat loss peptides available in 2026, covering every possible mechanism your body uses to burn fat. Growth hormone, mitochondria function, appetite, and cellular metabolism.

[00:00:16]You're probably using only one of these levers when you could be pulling all of them at once, which is insanely effective for losing body fat faster than you ever thought was possible. I've tried every single one of these 12 peptides. And today, we're ranking them from S tier to F- tier, breaking down the dosing and the mechanism for each one and building the perfect peptide stack to get shredded this summer. In case you're new here, my name is Victor Jill, a former IB Pro bodybuilder and performance specialist to thousands of high performing men. Before we go any further, nothing we go over in this video should be misconstrued for medical advice. I am not a doctor and everything we cover is for your education entertainment purposes only so you can have the conversations your doctor is not having with you and ironically the first peptide on this list is one of the doctors love to prescribe. Peptide number one semiglutide aka ompic. This one goes straight into the F tier and I know it's going to piss a lot of people off. Semiglutide is a GLP-1 receptor agonist. It mimics a hormone your gut naturally produces after you eat and it signals your brain when you're full and slows the gastric emptying and reduces your appetite dramatically. It works.

[00:01:20]The clinical data backs it up and people are losing weight on it. So Nick, why the hell is it F tier? Because in 2026, semiglutai is the worst version of a drug class that has gotten significantly better over time. It's a single agonist that hits one receptor. And when you compare it side by side to what else is on this list, it's not even close. The side effect profile is also rough for a lot of people. The nausea, the vomiting, the gastro issues, and the one that nobody talks about, well, the muscle loss. Semiglutide does not discriminate between the fat and muscle when it's dropping your body weight. And for men who spend years building your physique, that trade-off is not worth it. Look, if you're obese, semiglutide is what your doctor prescribed you and it's what you have access to. It's better than nothing. But if you're watching this video, I can assure you that you can get access to better options. I know somebody. Which brings us to the next peptide on the list. Peptide number two, turppatide aka Munjaro. And this one lands in the B tier. It's a significant step up from the semiglutide, but not quite at the top of this list for the reason I'm going to get into in a second. Teptide is a dual agonist. Hits both GLP1 and GIP simultaneously. The second receptor, GIP, is what changes the equation because it works synergistically with the GLP-1 to enhance its insulin sensitivity, improve the fat oxidation, and produce meaningful and better fat loss outcomes than the semiglutide does alone. The clinical data on this is not even close. Tzepide consistently outperforms semiglutide on total weight loss. And more importantly, the side effect profile is significantly more tolerable for most of these people using it. less nausea, less GI issues, and better overall adherence because people actually feel okay on it. The muscle loss problem is still there, though.

[00:03:09]Sorry. And that's the caveat with this entire drug class. Toeptide is no exception, though. If you're running this without anything to protect your lean muscle tissue, without getting enough protein and nutrients, you're going to lose muscle alongside the fat.

[00:03:22]But that matters enormously for you probably if you're watching this video cuz I'm pretty sure you don't want to look like Christian Bale in the machinist after your cut. With your though the patients usually start at 2 and a half milligs, sometimes 2 milligs weekly. They titrate up to a maintenance dose of yeah 10 to 15 milligs depending on their tolerance and their goals of course. With that being said, why isn't higher than the B tier? Because we have a triple agonist on this list that makes Trozeptide look like a stepping stone.

[00:03:49]Which brings us to the peptide that took everything Tzeptide does and added on an entirely new mechanism on top of that.

[00:03:55]Peptide number three, reatride. This one goes straight into S tier. No debating it. Rea is a triple agonist. It hits the GLP1, the GIP, and the glucon receptors all at the same time. I know you heard that a thousand times. What that actually mean though to you? Think of it like this. The GLP1 is the bouncer at the door. It controls your appetite. It tells your brain when you're full and slows down how fast the food leaves your stomach. The GIP is the second layer.

[00:04:21]Now, it works alongside the GLP-1 to enhance your insulin sensitivity and prove how efficiently your body oxidizes the fat. That's tzeptide. Now, you add the glucon on top of that one. Well, it signals your liver to basically start burning the stored fat for energy. It cranks up something called thermogenesis and accelerates the fat oxidation around the clock. This means your body is being pushed to actively hunt down stored body fat and burn as fuel even when you're at rest. That's a completely different animal if you ask me. The clinical trial data reflects exactly that. The phase 2 trials show that participants losing an average of 24% of weight on the red tide was basically someone walking around at 250 lbs waking up at 190. The muscle loss caveat still applies though because running something like this very aggressive without protecting your lean muscle tissue is a mistake that most people are going to make. We're not going to let that happen though. So the best idea if you're going to get into running rea is to always start at the least effective dose. I personally start at.5 milligs weekly and I titrate very slow up to 3 4 milligrams over 6 to 8 weeks once a week. Don't micro dose bread if your goal is fat loss. Make sure to check out this video next to also see my entire 16week Red True Diet experiment and how I got down to 8% body fat. Now, while this GLP-1 conversation gets all the attention, there's an entire category of fat loss peptides working through a completely different pathway that most men have never even considered taking, and that is the growth hormone optimization. Which brings us to peptide number four, Tess Morlin. This goes right into S tier alongside renatide. And the reason why is very simple. Tesarelin is a GHR analog, meaning it stimulates your pituitary gland to produce and release your own natural growth hormone, not synthetic HGH that's injected from the outside. Your own GH produced the way your body is designed to produce it. And what makes Tesarellin different from any other GH peptide on this list specifically that this compound literally was developed and FDA approved to target the visceral fat. That's the dangerous stubborn fat sitting deep in your abdominal wall wrapped around your organs. Tesmearellin goes after it directly and shows very meaningful reductions in visceral atapost tissue without the dramatic changes to your diet or exercise. Now imagine what it does when you combine it with a properly built peptide protocol and stack and your training nutrition is dialed in. It also improves your IGF-1 levels and supports lean muscle retention and has a remarkably clean side effect profile compared to everything else in the GLP1 class. Typically, you want to start with something like a half a milligram, even one milligram subcutaneous injection five days a week, administered before your bedtime to align with your body's natural GH pulse. S tier, and it's very underrated. Next up, two peptides that work best when you run them together.

[00:07:12]Peptide number five and six, CJ 1295 and you guessed it, I melon. These two get covered together because, well, running them separately doesn't make much sense if you ask me. They're a stack within a stack. And the reason why it comes down to how they actually work both land in a tier because CJC25 is a GHR analog, the same class as testin. It stimulates your pituitary to produce and release growth hormone. And I melanin is a GHRP, a growth hormone releasing peptide. It works through a completely separate receptor to trigger the GH release and also suppresses the somatin, which is the hormone that tells your body to stop producing GH. So, what happens when you combine these two? You get a significantly larger and also cleaner GH pulse than either compound can do by itself. Better fat oxidation, better muscle retention, better recovery, and better sleep quality. All from optimizing a hormone your body already knows how to use. The reason this combination sits in the A tier instead of the S tier is very simple. Tesmelon is a more targeted and more clinically validated and specifically for the visceral fat reduction. CJC and Hypermelon are way broader and they're optimizing your overall GH output rather than targeting a specific fat depot.

[00:08:25]That said, for men who aren't ready to jump straight into test morelin or want a more accessible entry point into GH optimization, this combination is the one. Clean, very well tolerated, and highly effective is a foundation for any fat loss stack. The dosing for these peptides CJC25 sits at about 200 to 400 micrograms combined with iMlan about 100 micrograms to 300 micrograms subcutaneous injection taken together right before bed 5 days a week is the best entry point into GH optimization on it entire list. Now let's move into the peptide that gets lumped into the GH category constantly but actually works through a completely different mechanism entirely. Peptide number seven, AODD 9604. This one goes straight to Btier.

[00:09:11]And here's why it doesn't rank higher despite what you probably already heard about it. AODD9604 is a synthetic fragment of the human growth hormone molecule, specifically the tail end of the HH peptide chain that's responsible for your fat metabolism. The idea behind it was to take part of the HH that burns fat, isolate it, and use it without triggering the insulin resistance and all the other side effects that come along with full HGH administration. In practice, the results are way more nuanced. Of course, AOD9604 does stimulate lipolysis, meaning it signals your fat cells to break down and release stored fat to be used as fuel. It also inhibits lipogenesis, which is your body's ability to convert excessive calories into new fat cells. Both of those things are generally useful for fat loss. Obviously, what it doesn't do is produce the dramatic systemic results that the GH peptides above on this list produce. It's a targeted fat burning tool. Where it earns its place is in a stack with other compounds beside as a standalone compound for fat loss. I would personally say it's underwhelming.

[00:10:14]But layered on top of tesmearellin or CJC25 and hypermelon it has a very specific lipolic signal that complements everything else running alongside it.

[00:10:24]The dosing is typically looking like 300 to 400 even 500 micrograms subq injected about 5 days a week ideally done in a fasted state in the morning to maximize the lipolic effect. So B tier it's a good supporting player coworker but not a solid standalone option. Now, we're going to shift into a completely different category, which includes some of my favorite and most impressive peptides available right now.

[00:10:48]Mitochondria peptides. These are the compounds that neither suppress your appetite nor spike growth hormone. They work at the cellular level, optimizing the very machinery your body uses to produce energy and burn fat. Starting with one of the most exciting compounds in this entire space, peptide number eight, Matz C. This one goes right into A tier. It's probably the most underrated compound on this entire list because Matsi is a mitochondria derived peptide meaning it's not coming from a lab formation of something very synthetic. It's actually encoded in your own mitochondria DNA. Your body produces it naturally. The problem is that its production declines significantly with age and chronic stress and poor sleep and you guessed it metabolic dysfunction. So what does it actually do? Mi acts like an exercise mimeic. It activates AMPK, which is one of the most important metabolic switches in the human body, which signals your cells to start burning fat for fuel instead of storing it. It improves your insulin sensitivity. It enhances the glucose spike and the uptake in the muscle tissue and increases your body's overall metabolic rate without stimulating your central nervous system. In plain English, it makes your metabolism behave like it did when you were younger and leaner. The research on Matsi also shows meaningful improvements in exercise capacity and endurance, which means you're not just burning more fat at rest, you're also able to train harder and recover faster, which compounds the fat loss effect over time. This is also one of the fewest compounds on this list with the data showing direct anti-obesity effects independent of what your calorie intake is. Your body gets better at burning fat even when your diet is not perfect. Who doesn't love this? The dosing for Matsi typically starts at two to four milligrams. Can go up to five to 10 milligrams subq as always. Two to three, four, five times a week depending on it. Some protocols run it daily at lower doses. Let's say 1 to 2 millig to 5 millig depending on your goals. Again, this is an A tier peptide and one of the most exciting compounds in this entire space. Actually, even more exciting when you understand what it's actually doing. Next up is a peptide that works alongside MOS CI at the mitochondria level, but attacks the problem from a completely different angle. Peptide number nine, SS31. This one lands in the A tier besides Mati because SS31 is a mitochondria protected peptide. Where Matsi activates your metabolic machinery, SS31 repairs and preserves it. Now, as you age, your mitochondria become damaged and inefficient, not strong enough. The inner membrane of the mitochondria where energy is actually produced starts to deteriorate. Your cells produce less ATP. Your metabolism slows down. Your body becomes very less efficient at burning fat and your energy levels drop.

[00:13:25]SS-31 works by directly targeting the inner mitochondria membrane, reducing the oxidative stress and restoring the mitochondria function back towards your younger age when you had a very efficient baseline. When your mitochondria is functioning the way it's supposed to, your cells burn fuel more efficiently. Your energy output increases and your body's ability to oxidize fat improves dramatically. The other thing that SS31 does that nothing else on this list does as a profound cardiovascular protective effect. It improves cardiac output. It reduces inflammation at the cellular level and has shown remarkable results in research around heart failure and metabolic disease. Is SS31 a dramatic fat burner on its own? No, I'm not saying at all.

[00:14:09]But that's not the point. The point is that every other compound on this list works better when your mitochondria is healthy and efficient. And if you stack it with Matsi, you have a mitochondria optimized protocol that most men have never even considered. And that is exactly why it's an A tier if you ask me. Now, the dosing for SS31 is typically 5 milligs to possibly 10 millig subq daily. Some protocols run it at higher depending on obviously what your initial starting dose is and then taper to a maintenance dose over time. A tier and probably the most underappreciated compound on this list for long-term metabolic health. Now we move into two of the most newest and more experimental compounds on this list. These are the ones that have been in the research community and I'm very generally excited for them right now because they come with a very few important caveats. Peptide number 10, Slooh PP 332. This one lands in the B tier for now. And that for now is doing a lot of the work in that sentence. I'm gonna explain why. Because Slooh is an exercise mimeic. Specifically, it's an err agonist. It activates estrogen related receptors, alpha, beta, and gamma simultaneously. And before you tune out the word estrogen, this has nothing to do with estrogen itself.

[00:15:21]These receptors are primarily responsible for regulating mitochondria biogenesis and fat oxidation and endurance capacity in the muscle tissue.

[00:15:30]What that means is that Slooh essentially tells your body that you just ran a marathon without running the marathon. But why is it only in the B tier? Because we don't have robust human trial data yet. Everything we know right now is primarily from the animal studies and early research and the mechanism is sound, but the early signals are incredibly promising here. But anyone telling you they have a full picture of Slooh in humans is getting ahead of the science and themselves. The other caveat is administration. Slooh has a very short half-life, which means frequent dosing is required to maintain meaningful blood levels. That's a practical consideration worth factoring in here. People, for the men watching this who are early adopters and want to be ahead of the curve, this is one to watch very closely over the next 12 to 24 36 months. As far as dosing goes, if you're using an oral form of Slooh, 200 to 400 micrograms in an oral dose, you can try to use a subq injection at the same dose depending on its strength and potency and see how it works. I've had clients go up to 1 milligram of Slooh daily. Again, that's all based on the potency. Peptide number 11, five amino.

[00:16:37]This one lands in the B tier alongside Slooh and for very similar reasons.

[00:16:41]Fibonomq is a small molecule called an NMMT inhibitor. It stands for nidto titamine and N mithrase an enzyme that's been identified as a key regulator for metabolic rate and fat cell development.

[00:16:56]NMMT is essentially a metabolic break pedal. When NMT is actively high, which happens naturally with age and poor diet and metabolic dysfunction, your body becomes significantly more efficient at storing fat and significantly less efficient at burning it. We don't want that. Your fat cells get larger and your metabolic rate slows down and losing body fat becomes progressively harder no matter how disciplined or how hard you work. Five amino blocks an enzyme. When you inhibit NMMT, you essentially release the break. NAD+ levels in the fat tissue increase and the fat cells shrink up. Metabolic rate goes up and also your body shifts back towards this fat burning state. What's particularly interesting about this compound is where it works. 51Q specifically targets the atapost tissue your fat cells directly.

[00:17:43]Now that detail it's probably is its greatest strength and its current limitation for men who are already running a solid foundation of compounds and want to add another distinct fat burner on top of all those other things.

[00:17:54]51MQ is a generally interesting addition as a standalone peptide. I personally haven't seen great fat loss results from it. where I personally would add this peptide is stacking with another compound in a transition or an exit phase from a peptide like reachide. The dosing for 51mq is typically around 50 to 100 milligrams orally once or twice a day and it's one of the few combas on this list that is actually orally bioavailable other than slooh which makes the administration significantly more convenient than the injectable peptides above it. I personally would always tell people to always resort to a subq injection with peptides. I'm not a huge fan of anything orally because of your stomach acid eating it up, absorption, you're talking about liver damage, kidney damage, gut lining issues. I always tell people as long as you're comfortable with needles, an insulin needle, always go that route.

[00:18:44]It's more effective and you get way better results. Now, we get to the final compound in this tier list, and this one is going to be the most controversial placement of everything we've talked about so far and and covered. Peptide number 12, Milanotan 2. This one lands in the F tier and I know this is very controversial specifically for the fat loss. It's a synthetic analog of alpha MSH. What does that mean? It's a natural occurring hormone that activates something called melortin receptors throughout the body. Now most people know it as a tanning peptide. And yes, it does produce a significant increase in the skin pigmentation with all the sun exposure without the tanning beds.

[00:19:18]But that's not why it's on this list.

[00:19:20]It's on this list because melortin receptor activation has meaningful effects on appetite suppression and energy expenditure and the fat metabolism. You have MC4R activation in particular and this is one of the most potent appetite suppressing signals the brain has. This is actually the same receptor pathway that several pharmaceutical companies are actively targeting for the next generation of obesity drugs. When you activate the MC4R, you get a huge dramatic reduction in hunger, increased energy expenditure, and enhance fat oxidation. So, Nick, why isn't F tier? The side effect profile and the risks. A malotan 2 activates multiple meltin receptors simultaneously, and the lack of selectivity creates this range of side effects that make it very difficult to run all the time consistently. The nausea, the facial flushing, the spontaneous erections, the darkening of your moles, the elevated blood pressure are all very commonly reported, especially during the initial loading phase. The other issue is this. The fat loss effects are not dramatic enough on their own to justify the side effects when you have much more targeted options available on this list. Now that you know how all these fat loss peptides work and how effective each one is, let's zoom out for a second and look at the full picture before we build the perfect fat loss stack using these peptides. the perfect stack. The compounds at the top of this tier list aren't just more powerful version of the same thing. They're working through completely different mechanisms simultaneously. GLP1 and glucagon receptor activation, growth hormone optimization, mitochondria repair and biogenesis, cellular fat oxidation. And with that being said, time to build the perfect peptide stack using the compounds on this tier list. Now, this is me sitting at 235 lbs, around 9 to 10% body fat, and a physique I can easily maintain year round while being able to perform in the gym, run my business, and have fun. But let's say I had an extra 30 lbs of body fat on my frame, and I had 90 days to get back to where I am, and I'm building my perfect summer fat loss stack from scratch. The first compound I'm adding, reatr anchor of this entire protocol. Nothing else on this tier list produces the level of systemic fat loss output that rea does and nothing else covers the three receptor pathways simultaneously.

[00:21:32]You want this compound established and titrating in your system before anything else gets added in. I'm starting at a half a milligram subq injection once per week. That's it. No heroics here in week one. The titration process with rea is everything. Once rea is established and tolerating well, the second compound gets added in. I'm adding Matsi and SS31 together at this stage. And the reason is very simple here. Rea is placing a significant metabolic demand on your cells. You need your mitochondria running at full capacity to capitalize on everything rea is doing. And these two compounds ensure exactly that. MC C at 5 to 10 milligs per week, SS31 at 5 to 10 milligs daily. After 8 weeks, I'm adding CJC25 and Hypermelon testin.

[00:22:14]Eight weeks into a significant caloric deficit, muscle protection becomes just as important as the continued fat loss.

[00:22:20]CJC and Imelon optimize overall GH output and protect my lean tissue. Tess Morel goes after something more specific, which is the visceral fat directly. And by week 12, the stack is at full capacity. Appetite regulation, mitochondria efficiency, growth hormone optimization, and the visceral fat targeting all running simultaneously.

[00:22:40]Now, if you want to see the exact step-by-step protocol, the dosing and nutrition strategies I use with this exact stack, you have to watch this video next where I walk you through everything. If you got value from this video, be sure to subscribe and leave a comment about what peptide you're adding to get shredded this summer. Thanks for watching and of course I'll see you in the next