The Peptide PhDs Podcast: Are Oral Peptides Actually Effective?

Added: 2026-05-12

[00:00:00]Heat. Heat.

[00:00:33]Heat.

[00:00:38]Heat.

[00:00:53]Good afternoon and good evening. Uh, welcome to the peptide PhDs. Now, Dr. Jones, my usual wingman, is in Barcelona right now. What's he doing in Barcelona?

[00:01:05]There we are always on the hunt for peptides. So, he is meeting with some really important people there. We I am back from Dublin. Uh, we hosted live from Dublin last week. This is episode 47 on May 7th. It is May 7th, isn't it?

[00:01:18]Yes.

[00:01:19]>> All right. So, I'm going solo, but not quite. I have a very special guest with us tonight, and her name is Crystal Bartlett. No relation.

[00:01:28]>> Hello.

[00:01:30]>> Yeah. So, you know, I'm very nervous to do this on my own, so I always need a little bit of extra help. And uh Crystal, >> he needs me to keep him humble and truthful.

[00:01:39]>> That's true.

[00:01:40]>> And say, "Move on. The science is boring. Let's go." Or if the science is un unintelligible, you can point it out and tell me to start again.

[00:01:48]>> Slow down. What does that mean? Yeah.

[00:01:50]>> Yeah. So, um, let me tell you a little bit about Crystal. We met about 30 years ago, and I was a single dad with five adorable children, but I don't know if they're very adorable to a 24-y old single lady. But, um, we are both scientists. Crystal is a food scientist and a nutritionist, so she has every right, every right to be on this podcast with us tonight.

[00:02:14]>> Yes, absolutely. Yep. I met this incredible man with this really cute Aussie accent. And how girls, come on.

[00:02:21]How can you resist an Australian accent?

[00:02:23]>> Yeah.

[00:02:23]>> I mean, even to this day, we go out and the servers or the cash register people will be flirting with him right in front of me like, "What's that accent?" I'm like, "Oh my gosh, I'm right here." So, I know the accent makes us do crazy things.

[00:02:36]>> Yeah. doesn't doesn't help when I'm leaning on the cash register with my hand head in my chin. No, I don't do that. Not really. Uh, yes. Well, today we've got some very cool subjects to talk about, right? We're diving into um actually a newly published science news article that's raising a big question.

[00:02:54]Are peptides truly proven as health aids? And is the FDA about to open the door anyway? So, we feel like this is a critical moment for the future of peptides and we'll break it down. So, there'll be some regulatory stuff tonight, which is normally super boring, but Crystal actually has her own company where she does regulatory work. So, she's an FDA compliance expert, so she's uh we're not paying her.

[00:03:20]>> Well, I'll collect payment later.

[00:03:22]>> Okay. I don't know what that means. Um, and I don't think I'm blushing again.

[00:03:26]So, um, and then, uh, we're also going to do some Q&A. We'll probably kick off with some Q&A. We had this amazing meeting last night uh with our affiliate community and they asked us a bunch of really good questions and I thought let's not waste those. Let's uh download the some some of those on the podcast.

[00:03:41]Some of them you've heard but uh you know we'll answer them again with maybe a little bit of a twist. Um okay. So quest crystal you're going to be my assistant and read the questions right because it just sounds a lot better when you ask and plus the Americans understand you and they don't understand me.

[00:03:59]>> Okay. first.

[00:04:01]>> It's an absolute pleasure to be on the podcast and I love this Make Wellness community and all of you out there that are um excited about their health and nutrition and being their best selves.

[00:04:12]It's totally um the best community to be part of and I love the events I've been to. So, thanks for putting up with me today. And our question number one, how do you combat or explain when people say oral peptides aren't effective? It's a really good thing that it's me tonight and not Allan because Allan would be red in the face right now and saying, "What do you mean?" Um, but I'm a gentle soul.

[00:04:38]So, I'm going to I think that um well, the first of all, when someone sort of says to you, "Hey, oral peptides, they're not effective." They're coming from a place of um what would I say?

[00:04:51]Either they're coming from the world where the only peptides that they've heard of are either drugs or in the compounding pharmacy, right? And what do we know about peptides that are in the drug world or compounding pharmacy at least up until very recently?

[00:05:03]>> Injectable.

[00:05:04]>> Injectable, >> right?

[00:05:05]>> And so they say, well, I know uh they're injectable because they don't survive the gut. So interesting though that um even if they are injected, you don't actually circumvent digestion.

[00:05:19]>> Really?

[00:05:19]>> Absolutely. In the blood, it's absolutely full of these enzymes that are peptidases and proteasis. Oh, in your blood.

[00:05:28]>> In your blood.

[00:05:28]>> Not just your gut.

[00:05:29]>> Absolutely.

[00:05:30]>> Wow.

[00:05:30]>> Yeah. And this is what we know about natural peptides. So, we know that peptides are really just a little string like like pearls on a bead on a pearls on a bead, beads on a string, >> pearls on a necklace, but they're all a little bit different, right? And they they they make this combination of amino acids and they're um yeah, it's right for people to believe that they're quite delicate. They're broken down by enzymes. Now, the body produces peptides as well, things like GLP-1. How long does GLP-1 last in the body? The one that your gut produces, which is sent immediately to the blood.

[00:06:03]>> Really short.

[00:06:04]>> Yeah. Four minutes. Four minutes. They call it a half life.

[00:06:07]>> So, in four minutes, half of it's gone.

[00:06:10]Why? I didn't know that there were enzymes in the blood. Oh, you better believe it. Because this is how the body communicates. All of these little messages that are running back and forth in the body, they are peptides and small proteins. All of them except for the steroid hormones, but most of them.

[00:06:29]>> Nearly all of them.

[00:06:31]>> So, so the body knows that it has to generate the signal, but it only has a certain amount of time to find its receptor and activate it and tell the body to do something before that amino acid chain is broken down. And when it's broken down, it just turns into amino acids that are in the blood that are then taken up again and and recycled.

[00:06:50]And >> and that's because as soon as you're done eating in your primal instincts, you really should be seeking for the next meal.

[00:06:56]>> Yep.

[00:06:57]>> So even though our next meal is as quick as McDonald's, I don't eat McDonald's, right? Or Taco Bell.

[00:07:03]>> So it's so easy, >> but our old animal brain >> Yeah.

[00:07:08]>> doesn't know that. So as you're satisfied for just like 30 minutes or something, then you're out seeking more food. It's really kind of >> it's primal because we come from, you know, we were designed perfectly for this. You've heard me say this before, right? It's evolutionary biology. We were designed for a very scarce environment. So that that uh desire to eat is very >> I don't even have to go through a drive-thru. I can just order it on my phone. It just pops up on my doorstep now. My food, it's just too easy, >> right? When does it pop up on the doorstep? I thought you always cook those foods. Have you Do you just get food delivered and then put it in our dishes and pretend you cooked it? That's right.

[00:07:46]>> Dang. Well, okay, back to the question then. So, when people say oral peptides aren't effective, well, actually, even the injectable ones aren't, unless >> they're synthetic. Now, when they're synthetic, what happens is pharma or the compoundingies, they get that natural peptide and they say, "Wow, dang. It binds to the receptor, but it's going to break down really fast." So it's not very powerful drug when it breaks down so quickly. You'd have to just keep on injecting it every five minutes. So what do they do? They do amino acid substitutions. They say, "Look at that peptide. Okay, if we change out that thrienine for an arginine, will it last longer? And if we swap this one out, maybe um I don't know arginine for um maybe a peptide or sort of an amino acid that doesn't even exist in nature but that is known to be robust. Will it last longer?" So they do these tests and lo and behold they get a GLP-1 that lasts for a week instead of four minutes.

[00:08:42]>> Wow.

[00:08:43]>> That way you can inject it and maybe it would survive the injection better than the gut, but certainly it's injected and uh and voila. So that's the space people are coming from. So back to the question, what do you say? How do you combat that? Well, you say here's the thing. Maybe there are three answers and I hope I can remember them all. um because maybe there's four and maybe there's only two. The first one is nature provides peptides and always has that actually do survive the GI. What's your evidence for that, Mark? Well, the evidence is say colostrum. When a baby's born and it has its first milk, that colostrum is absolutely choa block full of peptides. Sure, there's protein there for nutrition, but there are peptides in there. These peptides are antimicrobial, antiviral. Um they impact sleep patterns. So they bind these receptors and the and so they are actually in there. Now if nature was incapable of making a peptide that could survive the GI, how do you explain that?

[00:09:45]>> Yeah. No colostrum and babies that makes complete sense.

[00:09:48]>> Yeah. And immunologists also know that uh for example the imogloabbulins. Do you guys know what they are? Ioglobulins are those little Y-shaped um they're basically antibodies, >> right? So the B cells make antibodies in the blood. Like if you have a viral or a bacterial infection, the B cells make the perfect antibbody that will bind to that um antigen and render it useless.

[00:10:14]Now those won't survive in the GI. But guess what? There's a particular imunoglobulin called IgA.

[00:10:21]And this IG, that's ones that are responsible for actually getting rid of parasites and those are mostly made for um parasites and they're effective in allergies, right? So when you have an allergy, it's probably your body overproducing some Ig.

[00:10:36]>> There's IGG and then there's IgA and that is in mother's milk and it survives the GI. It is not broken down. So nature can make strings of amino acids in certain combinations that are very resistant to breakdown by acid and enzymes.

[00:10:53]>> So that's part one. I hope you jotted that down. That's a pretty good argument. Part two, it's all about the structure. And it's kind of that's an addendum to part one, right? Is it's all about the structure, certain structures.

[00:11:05]Now, the enzymes that break down um peptides and proteins, they're very specific. um each there's not just one enzyme that can break down a protein completely. There's a whole bunch of them, a whole bunch of different flavors because enzymes are um very specific in their activity. So they will find what they call a cutting site. There's a particular enzyme that is only good at breaking down say a positive amino acid that's next to a negative one or maybe it's only good at a proline next to a thrianine. So they are super specific and so it is possible that nature can say well I know the tricks I know how to make one that survives in the GI right so that's two it's all about the structure and we know that >> third argument when you eat a steak or drink a milkshake or something and you've got protein in there there is a common belief that the enzymes break it down absolutely completely down to the last amino acid and and that's it >> now you're a nutritionist Crystal does that sound plausible >> I know I'm thinking like the first part of digest ion is chewing. Those are chunks and you swallow it and it gets down to the stomach acid.

[00:12:11]>> Eventually, it's trying to make it. So, I guess I do have the impression that little amino acids are floating around >> in the blood.

[00:12:17]>> Yeah. What we know though is that it's not a complete digestion. It takes almost the entire digestive tract to break down.

[00:12:26]>> All the intestines.

[00:12:27]>> Yes. So, in the intestine, stuff is still breaking down.

[00:12:30]>> Yeah.

[00:12:31]So, um, so we do know that you eat a steak, there's going to be a chunk of, um, what you would call, um, structural peptides, meaning that there's there are strings of amino acids in these short sort of protein type lengths, but they're not bioactive. They don't bind to receptors, but some of them do.

[00:12:48]>> That's why we know that there are certain collagen peptides that survive the GI and can get into the skin and trick the skin into actually um, thinking that there's damage and producing collagen and elastin, right?

[00:13:00]more on that. That's a little preview of what's happening in later on in May. All right.

[00:13:04]>> Wait, can I ask a question about this one? So, the GLP1s, the injectable, the the drug companies have come up with a oral version, right?

[00:13:12]>> Don't they have a So, wouldn't that be a reason why you can trust or is that is that number four?

[00:13:18]>> That's number four.

[00:13:19]>> What a segue.

[00:13:20]>> Seriously, not in the notes.

[00:13:21]>> We're on the segway. Except I'm going to talk to you about that food delivery later. Okay, so here's the thing, right?

[00:13:27]We know that GLP-1 is injected and then recently they released a an oral form.

[00:13:32]How did they do that? If they've been injecting it all this time, what did they suddenly do to make it work in the GI and bypass gastric digestion? What they did was they enroeded it, right?

[00:13:42]They use certain tricks and tic coatings, right, that protect from acid until it gets lower in the intestinal tract. Um they do other things that um prevent it from being broken down. They use a higher concentration. So maybe you only inject a few milligrams into the blood but they have a higher concentration and it's enroed and protected.

[00:14:01]>> Now what say us about natural peptides?

[00:14:04]Actually nature does that automatically.

[00:14:07]>> So the father bean peptide that's in in our um fit for example that helps b helps maintain and increase muscle mass.

[00:14:16]>> That one actually when it's extracted from the fava bean comes with it with an entourage of proteins, small peptides and amino acids. on to rub us.

[00:14:24]>> So you would call it, if you're a food scientist, you would call it a food matrix.

[00:14:28]>> Oh, a food matrix. Yeah. Yeah.

[00:14:30]>> And you'll notice that we use like um the clinically studied dose say of the um of the peptide from fiber of 2.4 grams.

[00:14:38]>> Only a very small percentage of that is actually this is this protein entourage, this food matrix. And there certainly more than enough to um be chaperon to the receptors >> which I always feel is safer when it's kind of in a food natural form because it does come with the other elements that were meant to be together. It always makes me drugs worry me a little bit when they're so isolated down to a single molecule and then manipulated and changed on top of that. I know very powerful very nature but you're playing with fire a little bit especially when you have such a long halfife. Yeah, I like that.

[00:15:12]>> Okay, so that's question number one.

[00:15:14]>> Good question. Well done.

[00:15:16]>> You've been armed with four bullet points there.

[00:15:18]>> Okay, number two. Oh, can you froth the peptides super lightly?

[00:15:23]>> Wow, look how couch that question because I know in the past you've asked that people have asked that question and we've said yeah I don't know frothing doesn't seem like a good idea. Like peptides are fairly delicate and you don't want to mess them up too much. Uh but in our trip to Dublin as we talked to the biotech company and the folks and the scientists that um that have been looking into this, they've done a lot of work since we launched that product and that work showed that actually the peptide is extremely robust.

[00:15:53]>> You can put it in a solution, a food solution down to pH2.

[00:15:58]>> Oh, >> what's the pH of the GI crystal full of hydrochloric acid?

[00:16:02]>> I know three.

[00:16:04]>> More like two.

[00:16:04]>> Two.

[00:16:05]>> Yes. So, they've actually proven, well, they already did this, right? They they've used a gastric acid solution.

[00:16:10]All of our peptides are proven by using a synthetic or a uh a gastric acid solution, not not from human gut, but exactly the same pH and everything else and churning to make sure that it survives, right? So, we know that. We also know that you can heat it quite hot. Like, I wouldn't boil your fit, but um you can actually put it in your hot drink and it survives.

[00:16:32]>> Like a coffee in the morning or something. Wow. It's kind of a weird thing to do with your peptide, but you know, we've got weird people out there, don't we? Um, and then the other thing is the froth, right? So, can you use a frother? And we've always said, well, you know, I'm really not sure that you should do that. Well, it turns out you actually can. You can froth it. Like, I wouldn't go absolutely bonkers with a frother.

[00:16:53]>> So, maybe a blender would be too aggressive, maybe, but like a >> Yeah, your little frother is fine. And we talked to someone last night and they said like good cuz I love my frother.

[00:17:04]You know, you can have my frother when you pry it out of my cold dead hands.

[00:17:08]And uh and then I remembered that we have a constitution and I think that's article um that's one of the amendments 2.5, right?

[00:17:15]>> Yeah.

[00:17:16]>> Is the right to bear frothers. So you're good with the frother. Okay.

[00:17:20]>> That's why he loves me because I laugh at all his dumb jokes.

[00:17:24]>> He's like Chris will come on this show so she'll laugh at my jokes. That's all I need. I need it's a self-esteem thing.

[00:17:30]>> Well, I find the caffeine-free fit has quite a froth on it by itself. I really like that.

[00:17:36]>> You would love this shaking. We've done >> our food scientists have done marvelous stuff on this. So, we went back to the far the biotech company and they've got um they've got a team that actually sort of does all sorts of dosage forms, >> but they nearly always taste a little bit like the bean.

[00:17:53]>> Nobody really likes that beanie taste.

[00:17:54]>> Yeah. Our food scientists have a reduced that beanie flavor so that you don't get it and b reduced the froth because when we first got that, oh my gosh, when you tried to mix that stuff, it would have a head on it like a Guinness.

[00:18:10]>> So, um yeah, we've done some pretty good magic with that. There's a little bit of foam there, but man, it's nothing like >> I sometimes wake in the morning, I just can't wait to drink a pin colada that's just creamy and delicious. It's not an advertisement. I >> I'll tell you a little secret. like, you know, we weren't going to go anywhere near a caffeine-free fit. But then Crystal kept complaining.

[00:18:27]>> I cannot drink that much caffeine. It just doesn't work with my body. I get all like shaky and and anxious. And so, thank you for making the caffeine feed.

[00:18:36]>> It was awful for Crystal. You guys out there in the Make Wellness universe think it was for you.

[00:18:40]>> But I love it because I can now I can I used to only take it on the days I exercised and I but like a yoga day, I wouldn't do it. It would only be the gym days. And now I can take it consistently every day. And I think consistency is the key >> and you do need muscles to do yoga. So what so what we observed here is that there are probably a lot of people that feel like fit is a pre-workout drink.

[00:19:02]It's really not right. It is something that should be taken consistently every day to help maintain muscle mass and even to grow muscles like my amazing muscles that >> I love being on vacation and knowing well I'll be walking today but I won't be lifting weights and maybe a week which is probably good sometimes to take a break but I just feel like I've taken my peptide. I'm going to keep my muscles through this vacation. Yes. Makes me feel better.

[00:19:22]>> Yeah. I was really only joking about Crystal. I'm saying that cuz she's here, but I really did it for you guys.

[00:19:27]>> Yes.

[00:19:28]>> Okay.

[00:19:29]>> Okay. Can I ask the next question?

[00:19:31]>> Yes, please, ma'am.

[00:19:32]>> Okay. What are you most excited about with bioactive precision peptides?

[00:19:37]>> Wow.

[00:19:38]>> What are you most excited about?

[00:19:39]>> Nobody's ever asked me that question before. Actually, they did last night.

[00:19:44]So, okay. Here's what I'm most excited about. The fact that they are natural like this is so important guys the fact it's more important than people know now why is that why is the fact that these peptides are natural these bioactive precision peptides they're not synthetic >> well I already alluded to it earlier right safety in evolution the halflife >> so the synthetic ones like GP1 um it has a long halflife now the body is really designed to create the message. The message is broken down very quickly and then it recreates the message as you need it. And I feel like peptides should work with your body, not shout against it. So the the receptors in your body are not used to having a receptor just be I mean a a peptide be alive for 24/7 for a week, right? That's just not how they were designed. It's like jamming your foot in the door. It's like the fire alarm going off constantly or the smoke detector going off even though the smoke has long since cleared the building. It would drive you baddy and it drives the body baddy. That's an alliteration that I like. Um so GLP1 for example, yeah, if it lasts a week instead of just four minutes or so, um it's shutting down the GI which has its own set of issues. it is shutting down your body's um sort of um hunger setting which then leads to sort of an anorexic behavior right you sort of go into starvation mode it puts the body into a great deal of stress now I'm not trying to bag on this too much right I know there are medical reasons why people should be taking GP1s it was really invented for diabetics and it works marvelously and helps reset their metabolism and then it's sort of the side effect was weight loss because you sort of lost the desire to eat, but I feel like it can be abused, right? Um, >> yeah, I'm a little worried about about Hollywood whenever I see Hollywood stars. I feel like they finally achieved their goal weight and the rest of us are going, "Yep, >> is uh she need help?"

[00:21:47]>> It's Homer Simpson sitting in the chair with his doctor, right? And say, "Well, how come there's none left for me?" And I just, >> is it because there are people with even worse diseases and are more overweight than me and they need it? And the doctor says, "No, Homer. It's the Hollywood A-listers. They're going through a really hard time right now.

[00:22:04]>> Well, and I'm sad for our for our daughters and our girls. That's that's uh not the ideal.

[00:22:09]>> Yeah, the body image thing is really shifting, isn't it?

[00:22:11]>> I know with me, I know you probably talked about this that gaining muscle is now my goal, which is so fun. All you weightlifters that been clued into that.

[00:22:19]It's kind of a newer idea for me as I'm getting older.

[00:22:21]>> Used to be only a dude thing.

[00:22:22]>> Yeah, >> I don't know if I'm comfortable with women appreciating muscle now. I've kind of stopped looking at the scale weight because it really doesn't help me because my goal I so I do like a inbody scan so that gives me my percent muscle and my body fat and so I' I'm looking at a totally different thing now and it's um encouraging me to make muscle and keep muscle and I'm feeling amazing and my clothes fit the fit better and I feel energetic and I know my bones are strong and my joints are strong rather than like shrinking away to this tiny maybe ideal weight that I was programmed to think was the right number and being weak and airheavy and not enough calories for the brain to work. So, I know all of you are out there feeling the same way. I'm really pleased with the fit muscle approach right now. It's really exciting.

[00:23:11]>> Yeah.

[00:23:12]>> And kind of feminist in a way. It's really empowering us.

[00:23:15]>> Yeah. I I've got a Guys, I just I was reading an article earlier today and this is so interesting while we're talking a little bit about GLP1. Okay, here we go.

[00:23:24]Um, this is from Natural News. The military the military spent some money on GLP1 drugs >> in 2025.

[00:23:33]>> Okay.

[00:23:33]>> Can you have a guess how much they spent on that drug? GLP-1 drugs.

[00:23:38]>> 100 million.

[00:23:39]>> $700 million on GLP-1 drugs in the fiscal year 2025.

[00:23:44]>> Wow.

[00:23:45]>> So, I'll read a little bit. The Department of War spent 700 million on glucagon like peptide 1 GP1 receptor agonist medications including ompic during fiscal year 2025. According to the report from the Pentagon's health agency, the spending covers prescriptions for active duty service members, military retirees, and their dependents enrolled in the military health system. Um so that is so interesting, right? Uh the report stated that the military's pharmacy benefit has covered GLP-1 drugs since 2022, but usage accelerated after the FDA approvals expanded indications for weight loss.

[00:24:22]>> Um and where was I? I read down a little bit further.

[00:24:27]>> The US military on the troops we're using GLP1.

[00:24:31]>> Yeah.

[00:24:32]>> Okay.

[00:24:32]>> Now, it said in here somewhere sort of that 22% I think of military were obese or overweight. So, I guess it's nice to have our military a little bit fitter.

[00:24:41]>> Yeah.

[00:24:41]>> But there have been some criticisms and alternative perspectives. Some lawmakers and healthy health policy analysts have questioned the spending. A member of the House Armed Services Committee said in a statement that the military should prioritize nutrition and exercise programs over expensive drugs. You know, of all the places um I would think that the military, like, you know, my boss can't say Bartlett 20 push-ups now and run around the field, right? But I believe that that's possible in the military, right? So you can actually like force them to exercise. Seems to me if you can force them to take a vaccine they don't want, you can force them to exercise. Um, other critics argue that drug reliance does not address the root causes of obesity. Um, Slim Land, Wow, that's a Oh, that was a Freudian slip.

[00:25:28]whose name is really Sim Lan, >> author of the longevity leap, notes that both low carb and low-fat diets produce weight loss, but that high-fiber diet intake promotes sustainable weight management without pharmaceuticals.

[00:25:42]That's the concept of um low caloric density, right? Which is proven. Um, and then, uh, Marty Machary, MD, in his book, Blind Spots, says, "When medicine gets it wrong and what it means for our health, I guess that was a subtitle of the book, observes that many widespread medical practices lack robust evidence, echoing concerns about long-term reliance on GLP-1 drugs." So, I think that's just really interesting. And and again, it goes back to saying, "This is why I'm excited about natural peptides because they do break down quickly.

[00:26:15]They're not as powerful as the drug peptides, but they are so much more sustainable, right? Because you learn sort of good habits while you're doing it. Takes the edge off your appetite and your unhealthy cravings, but doesn't um And then the idea of muscle, building your metabolic engine, that's a different >> I love the idea of metabolic engine.

[00:26:33]Yes.

[00:26:34]>> You one podcast about how your muscle is your engine. So, as we get older, we're not really losing our metabolism. It's just we're losing muscle. So that's why me focusing as I getting older on muscle, it's like I can go on vacation for a week and enjoy the natural or the uh international cuisines or whatever we're indulging in and know that my engine's still there working instead of just the treadmill and running is the only time I'm burning calories.

[00:27:00]>> And we've talked about that a lot on the podcast, right? It's very important to have muscle. And so why is it so difficult these days? Again, it's the same reason our bodies were designed for scarcity.

[00:27:11]And it used to be that we needed to use our muscle to hunt for food or to farm.

[00:27:15]And so we're using them all the time. So the body um naturally built the muscle, but it's metabolically expensive to keep it. So if you're not using it, the muscle produces a an enzyme or sorry a peptide called myostatin. You've heard of this before, right Crystal?

[00:27:32]>> Yeah. Yeah.

[00:27:33]>> And myostatin actually says, "Hey muscle, you're not being used. So break down. Break it down. Pull it down." Um, and that means that you don't have to consume as many calories at rest. And that's really how the body was designed.

[00:27:45]And yet, the muscle is so important for our youth to prevent frailty. And since we're not using it so much today in our jobs, we need some help. We need some help to sort of overcome that evolutionary gap. And did you know that the peptide in fit prevents myostatin?

[00:28:03]>> That's amazing.

[00:28:04]>> Yeah, it inhibits myostatin.

[00:28:06]>> Wow.

[00:28:06]>> So, you're really giving a signal to the muscle. Can you stay a little longer?

[00:28:09]>> Stops the breakdown of the muscle. Helps me keep it longer.

[00:28:12]>> Yeah. I mean, >> because it's hard work to make muscle. I didn't realize how hard it was to make muscle. And I have to learn a whole new thing. I have to get enough calories, the right calories, enough protein. And then I'm doing a I'm I'm learning. I just don't run on the treadmill for hours. So, not more cardio, less calories. And I'm I'm lifting weights and I'm feeling the burn, pushing past the burn to a failure. So, I'm learning a whole new vocabulary, a whole new thing.

[00:28:38]>> Because you and I are used to aerobic, right? I used to run marathons. You used to do sort of you have aerobics and treadmill.

[00:28:44]>> Oh, I used to do pranc dance around. Did you say prancerizing?

[00:28:48]>> That's what it feels like now that I'm back. Now I'm like a gym rat. I'm actually lifting heavy weights, tracking my weight, lifting heavier. So, it is a real mind shift. And it's so nice if you have a mentor that's kind of guiding you through. That's what um you out there are so good to do for your clients is to help them because fit is part of like you said is part of lifestyle. All these peptides are part of a healthy lifestyle but some of the lifestyle we only know what we know and it's hard to change.

[00:29:16]>> Yes.

[00:29:16]>> But I think once I've hit I'm 50 and it's like that model of less calories more cardio is not working anymore.

[00:29:25]>> Yeah.

[00:29:25]>> And it's really frustrating when it stops working. And so I'm um making muscle, keeping muscle with the peptides and my change in lifestyle, right?

[00:29:35]Higher calories and protein and >> and muscle failure. So it it's a really fun um adventure to be on. Mark always takes me on crazy >> health adventures. And I love this new peptide adventure. I mean, it's really you guys are on the cutting edge of this brand new science. I love it.

[00:29:51]>> It is the ants pants. And so again, to answer your question, that's what gets me so excited. And >> I'm excited. And while we have like the synthetic ones on the market, right, and people are sort of learning that there are pros and cons to that, um, here's what excites me again, natural peptides, because I do believe that the gravitational pull would be towards us, towards those people that are explaining how it works and that natural peptides are really the the sustainable answer.

[00:30:17]>> Well, my only experience with synthetic stuff has been like um my birth control options, right? There is like the natural hormone and then the drug companies modify it enough so they can patent it and it kind of messed up my body. I have to say I really don't love synthetic drugs.

[00:30:35]>> Yeah, >> I don't think they've been very friendly. And now I'm on this other side and I am doing HR2T but it's bio identical hormone replacement therapy and I have no side effects and it's working with my body but it's much cheaper because nobody patented those and jack up the price.

[00:30:51]>> So it's conspiracy, right? Can't patent a natural molecule, right?

[00:30:55]>> No.

[00:30:55]>> Yeah.

[00:30:56]>> Yeah.

[00:30:57]>> All right.

[00:30:57]>> Oh, you want me to ask another question?

[00:30:59]>> Okay. This is right up your alley, Crystal.

[00:31:01]>> Okay. What are some claims you've heard that we can't say? And are there alternatives way to say it? Alternative ways.

[00:31:10]>> Well, um I would say there are two things, right? First of all, I think this is pretty obvious, but I'm I'm sure that there are a lot of people listening to the podcast that may not understand these nuances. So, in the drug world, you can, you know, you'll hear the drugs, uh, their ads on the TV. You know, you're watching TV at the wrong time of day, right? When you get the drug ads, like, >> I know, >> I'm constipated >> or in the middle of the night or whatever.

[00:31:34]>> Yeah. So, those, um, they talk about disease all the time. If you have a drug, you can talk disease. If you have a supplement, you are not allowed to talk disease, right? That's is in the purview of the FDA. They're the ones that um if you have a they they say if you are claiming mitigating or curing a disease, what you have now is a drug and I want to see your new drug >> application or whatever they call it.

[00:31:59]They need the proof and it needs to be registered as a drug.

[00:32:02]>> Yeah. They're very territorial, the drug companies, they don't like us in their space.

[00:32:06]>> Yeah. So, you think about a peptide, a a a a supplement peptide that would be for muscle maintenance and growth. You wouldn't say I don't know what's a disease of muscle wasting. There probably lots. There's things like multiple sclerosis where you'd have muscle loss or I don't know some other like all sorts of diseases where you have muscle loss. You can't say it cures those diseases, right? That would be inappropriate.

[00:32:29]>> But what can you say?

[00:32:30]>> I mean what is the structure of the law that tells you what you can say?

[00:32:34]>> It builds and supports on normal body mechanism, >> right? That's called a structure function plan, right?

[00:32:40]>> So it's already functioning pretty good and you're going to support more of it.

[00:32:43]Yes. So, this is actually um from DAE, the Dietary Supplement Health and Education Act.

[00:32:48]>> Yay. Da.

[00:32:49]>> Yeah. And things were a little bit gray in the early 90s. And so, some very smart people worked with Orin Hatch to um basically draft this law that talked about what you can say about supplements and how you can say it. And you were involved in that a little bit, you was one of the principal attorneys on it. I It was kind of the beginning of my career in food science. And it's such a good thing because there used to be drugs and then there was food and there was really nothing in between. And the duchay really says, hey, people can make choices. People can make healthy, informed choices and there's herbs and there's nature and there's all these other grayer options. People should be allowed to do that. And so da lets us do that, but we stay out of the drug care territory. And then foods are basically just calories.

[00:33:36]>> Yeah. You can't make structure function claims or drug claims with food. Right.

[00:33:39]>> Right. So like even a cranberry juice, we all know cranberry juice helps with UTI, but you can't have a cranberry juice. It may say supports health or something, >> supports normal urinary function, >> but if you really do say helps with urinary tract infection help, >> that's going to shut you down.

[00:33:53]>> Then they would put that in like a functional category, the dish category.

[00:33:57]So that's the that's the space you operate in, we operate in, right? Yeah.

[00:34:01]>> Is in this dish or this functional food category, >> right? And I have a favorite food that helps keep me regular and it is called the mighty prune. I love prunes. I love the taste and I love what they do with my body.

[00:34:16]The mighty prune. But you know it is absolutely illegal to say that it cures constipation. The FDA just says no way buddy you're going to jail.

[00:34:25]>> You cannot say that. So that's >> or even like you picked up an orange, right? What was that? The scurvy that the pirates used to get on the boats because they didn't have fresh fruit and sea. You can't say vitamin or the cure my scurvy. You don't see signs about it everywhere.

[00:34:39]>> So there's definite distinct ways to talk about what is in it, right?

[00:34:44]>> Yeah. I don't think you can even say cure is the common cold, right? You would just say it's got vitamin C in it.

[00:34:48]Vitamin C is known to be good for your health as well.

[00:34:51]>> We're really lucky to operate in this category which is safe and has been around and is really protected. I feel like there's laws that really protects consumers choice on how they treat their body.

[00:35:01]>> Yeah. So that's the simple litness test, guys. um what you can't say is something to do with the disease. If you find yourself talking about a disease, then you're in um in uh dangerous territory and you're um you're not helping your business, you might put it at risk.

[00:35:15]There's one other area and this is a little grayer, but it's something that we've decided is really important.

[00:35:20]>> So there are drugs for diseases >> and for example, we've been talking a lot about GLP1 receptor agonists tonight, whatever their name, whether it's MARO oric, WGO V. So those are now prescribed for disease. And it is dangerous for us now to say we have something that works better or the same as a GP1 receptor agonist.

[00:35:40]>> Yeah. They don't like that.

[00:35:41]>> Don't get in my space.

[00:35:42]>> Yep. They don't like it. So they they'll shut you down pretty quickly. And you know, pharma has a loud voice and FDA does listen. They're kind of working together a little bit. So you can't avoid that conflict. So there's another one that you need to be really careful about.

[00:35:56]>> That's a good moment.

[00:35:56]>> Okay. It seems like this is a good time to um introduce you to this article that I read. So um I am a science nerd. I don't read Sports Illustrated. I don't even know how to play football.

[00:36:11]>> I told him, "You need to go look learn American football." So our our kids are American. I sent them off to to learn American football.

[00:36:18]>> I can play rugby. I went to a good rugby game in uh in Ireland. It was Yeah, it was the Irish versus the French and it was a great rugby union game >> and that was so fun. It was so good revenge for me because I'm sitting with with Alan Jones who played college football, right? And then Brett who coaches football and they're both like, "What's happening?"

[00:36:40]>> Ah, that revenge.

[00:36:42]>> What happened just then? I love that.

[00:36:43]And I'm like, "Just watch the game.

[00:36:45]>> Come on, bloss.

[00:36:47]You know the rugby rules." Okay, so >> this is a real man sport. So, I don't um subscribe to those cool magazines, but I do subscribe to science news, right? And so um in this month's edition of science news, there was an article and it was entitled this. It was in the health and medicine section news. Peptides are unproven as health aids. FDA may unleash them. Anyway, so someone was asking that question. I think it was uh was it Mark Simpson? What's happening with the FDA and all these peptides? So, I don't have all the answers, but I want to read some of this article to you, and I'm going to read it, and I'm going to criticize some of it, and I'm also going to look for your reactions, all you guys that are watching live. And I'm going to look for Crystal's reaction.

[00:37:29]>> All right, let's see.

[00:37:30]>> Let's see. Okay, it starts like this.

[00:37:33]And it was written by um by Jamie Ducham, May 1st, 2026 at 10 a.m. We know exactly when he started writing. Down to the hour.

[00:37:43]>> That's weird.

[00:37:44]>> Pick an ailment. joint pain, brain fog, insomnia, and there's probably a peptide therapy promising to treat it. Never mind that many of these amino acidbased products are not approved by the US Food and Drug Administration, have hardly been studied in people, and may not be intended for human use at all. Okay, what are they talking about here?

[00:38:04]>> I feel like those that gray that injectable but from China that you get off >> Yeah, these are the compounded >> the scary ones that aren't really.

[00:38:14]>> Yeah. And it's so interesting he said that never so I love that he pointed out these are amino acid based products but he said they're not approved by the US FDA. That's true. Most people don't realize that those compoundingies are not approved by the FDA um and have hardly been studied in people mostly animal studies. You guys know that if you've been listening to the podcast.

[00:38:33]Okay. Uh are you a little bit confused?

[00:38:36]Where does that leave us and our supplement peptides?

[00:38:41]Are we in the same boat? No, exactly.

[00:38:43]That's a different cate. That's a category that FDA hasn't formed and is >> yes, >> not and we don't need FDA approval because we are not claiming diseases.

[00:38:52]They are not drugs. They're not injectable. Here's another nuance, guys.

[00:38:56]A supplement according to the US FDA regulations and the federal code of regulations, section 111, if I remember correctly. Right? You know that >> um it's not a supplement if it's injected, right? It's not a supplement if it's smoked or inhaled >> delivered a certain way.

[00:39:15]>> Injectable is not a it kind of needs to be a food form, >> right? So these guys with the injectables can't call themselves supplements and we will never have supplements that are injected because it's just not allowed. But we have natural products that are extracted from food and we have studied them in people.

[00:39:32]We have clinical studies.

[00:39:33]>> Yes. In people. That's so nice.

[00:39:36]>> Keep that in mind when we read on. Some people aren't afraid to go do it yourself, buying peptides from online retailers or overseas suppliers and injecting them at home, whether their doctors know about it or not. Right now, um, this author has really done some homework, so he starts talking to some former FDA officials. And here's the next session section. There's a clear solution for regulators dealing with an illicit market like the ones emerging for peptides, says Mitch Zella, a former FDA official who left the agency in 22 2022. What do you think that clear solution is? What what do you get when you ask a regulator what the clear solution is?

[00:40:15]>> Make a law.

[00:40:16]>> Regulate the crap out of it. Right.

[00:40:18]>> And so this is what he said. Quote, "Step up your enforcement game to stop its spread."

[00:40:23]>> Wow.

[00:40:23]>> Two weeks to stop the spread.

[00:40:24]>> So, >> no, we won't go there. seizures and pulled off market and arrested chiropractors. I don't know. What does that look like? Kind of scary.

[00:40:31]>> Yeah.

[00:40:32]>> Well, so I'm looking at your screen in the middle of all this. You have a motorcycle helmet.

[00:40:37]>> What? Why is that there?

[00:40:39]>> Um, all right. This is embarrassing.

[00:40:42]Isn't the internet gray? Like, I'm in the middle of my internet, my digital version of science news, and up pops an ad for a helmet. They must know that I just bought a showy helmet for my motorcycle. Showy meaning the Japanese brand. It knows that I bought it.

[00:41:00]>> It makes you so happy.

[00:41:01]>> And I I guess I shouldn't have kept that from you, Crystal. Okay, the next section. How have peptides been studied and regulated so far? Some synthetic peptides are wellstied and FDA approved.

[00:41:13]Okay, >> the P in GLP-1, the wildly popular category of diabetes and weight loss drugs that includes ompic stands for peptides. But many of the substances people are using to self treat with names like BPC-157 and TP500 show promising effects in animal studies, but have not been rigorously studied in humans, raising questions about whether they are safe and work as advertised.

[00:41:36]>> So, they could apply to the FDA for FDA approval, but it would require what?

[00:41:41]like studies in humans and they're pretty strict about and all the side effects. I mean, every time I hear a drug ad, there's about, >> you know, >> 30 seconds of side effects that you should find and be careful about. So, they'll have to disclose all of it.

[00:41:55]>> Yes.

[00:41:56]>> And find out about it. And so, that's a long process. So, >> yeah. And in fact, we go through that.

[00:42:01]>> In fact, BPC57, they started a clinical study, but it was sort of closed down before it was finished. So, we don't know the results, right?

[00:42:08]>> Because it's dangerous or something. And so it says here for now I don't think it's dangerous but but let me read on here.

[00:42:14]>> For example, BPC57, a synthetic peptide derived from gastric juices found in the stomach has been shown to accelerate healing from tendon injuries and wounds in rats.

[00:42:24]>> Okay.

[00:42:25]>> But human research has been largely limited to very small case reports or pilot studies.

[00:42:29]>> Okay.

[00:42:30]>> Um here we go. A small human clinical trial was initiated in 2015 but canled before results were reviewed and published. Mhm.

[00:42:36]>> Um so here he leads to something um interesting. It was probably later in the article. I don't remember where he said it, but um it was isolated from the GI, but when you then turn it into an injection and you inject it into the joint, it may have unintended consequences. I don't know. So, okay, I I'm trying now to sort of scroll through this and find a um an intersection point with supplements, which is what we have, right?

[00:43:00]>> Um so, let me scroll down a little bit.

[00:43:04]Um, here we go.

[00:43:07]Um, Carmen asks, "Was that human gastro juices or animal?" It was actually human. So, BPC 157 was initially found in human GI.

[00:43:16]>> Um, and I'm not sure if the ones that So, the ones that they're injecting are synthetic. I'm not sure if they're nature identical. I suspect that they've probably been changed a bit, but I'm not sure. So, good question, Carmen. So, um, what would it mean reading on in the article, what would it mean to include peptides in oral dietary supplements?

[00:43:36]Loose, okay, I love this next part.

[00:43:38]Loose oversight also characterizes the current market for oral dietary supplements. Another arena in which peptides are a topic of interest. What do you think about that statement?

[00:43:49]Loose oversight.

[00:43:54]>> I don't know what they're saying there.

[00:43:55]Help me out. They're they're trying to sort of >> loose oversight.

[00:43:58]>> They're trying to paint the oral dietary supplement >> tobacos in the herbal area that think you can treat yourself about a drug.

[00:44:05]>> Okay. So, how loose is it, Crystal?

[00:44:07]Like, is there any oversight in nutrition?

[00:44:09]>> There's there's a lot. I mean, that da says you have to you can't just pick up something and put it in a supplement.

[00:44:15]There's there's upper limits for safety.

[00:44:18]There's um inspections of um of facilities, manufacturing facil there's GMPS. Yeah.

[00:44:23]>> Yeah. There it is rigorously watched.

[00:44:25]There's some outliers, some bad players that take advantage of it and eventually are shut down >> but and it may take a little bit but >> but generally there's a lot of self plenty of oversight. So the oversight is um guys listen to this. There's FDA people are telling us or telling you that this is a wild west but it is not as wild west as they make it out to be.

[00:44:48]Right? Actually you know take for example the fact that we have clinical studies on our supplement peptides and the area that's closer to pharma than us has no studies. Right.

[00:44:58]>> That's crazy. Yeah.

[00:44:59]>> And then take for example okay farmer has studied GLP1.

[00:45:03]farmer also apparently studied the co vaccines. That doesn't necessarily guarantee that it's safe for everyone.

[00:45:11]They try to say that but maybe this is controversial. I could be shut down but um shut you down.

[00:45:17]>> Okay. So the FDA um does monitor manufacturing like they audit our facilities. They go in there and say, "Are you doing good man?"

[00:45:26]>> All the raw materials that come in, they test for microbes and levels.

[00:45:30]>> Every raw material say, "What is that?

[00:45:32]Is that a food or is that a drug? If it's a drug, I'm going to shut you down." They, um, they look at allergen testing that you do, everything that you say, even your shelf life. They say, "Well, where's the data for that?" So, the FDA does monitor that. So, um, is that loose overight? I would say no, not really. And okay, there's another regulatory body, >> Federal Trade Commission, the FTC.

[00:45:55]>> FTC, >> those guys are about truth in advertising. If you tell if you if you say that your supplement does something and you have no proof that, no studies, they can shut you down as well. And not only that, fine you. Huge fines. And uh and they will um that comes along with a consent decree, >> which means if you do it again, we'll just completely shut down your business.

[00:46:17]So, it's very serious oversight. down to the detail like on your label if you have a picture of a strawberry but you actually have no natural strawberry flavors you can't do that right they're very it's very well regulated >> y >> I think >> yeah so it says it goes on it creates an environment where we have legalized snake oil says Peter Cohen an internal medicine physician at Cambridge Health Alliance right he's uh in Massachusetts who studies supplement safety that's so interesting that someone so educated would say that um legalize snake he because he goes on and says you can put anything in a bottle and start selling it. Well, I would disagree with that. All right. So, this is the world that we live in, guys. We have um natural substances. Yes, there may be some bad players. Um that's why really you sort of need to trust who you are working with and the kind of work that they're doing here.

[00:47:10]>> Definitely.

[00:47:11]>> Um All right.

[00:47:13]>> And scientists like you who give legitimacy legitimacy to the >> Yeah.

[00:47:17]>> the product. You wouldn't you have such integrity you'd never promote or sell something that didn't >> Yeah.

[00:47:23]>> have efficacy. It's it's good. You're a good trustworthy I think you're a trustworthy person. Yeah. Yeah.

[00:47:28]>> I don't know what is what does the good a mate thing say?

[00:47:31]>> Truth mate.

[00:47:32]>> I don't know if you are truth means it's the truth in Australian. So there you go. All right. So here's the thing. He he goes on talking to this guy Zella, right? This um I think he's the ex FDA regulator. Um he said there should be pre-market review of both safety and potential benefit. He's talking about um maybe using peptides in supplements. If that review took place, the results might be disappointing for manufacturers and oral supplements. So here we go.

[00:48:02]He's going to hit us with a bombshell.

[00:48:04]He says when peptides are swallowed, enzymes in the stomach typically make quick work of digesting them. If you swallow a peptide in a supplement, you would probably see no therapeutic benefit at all. This is Fetsy that's saying that, right? So, he's an expert in the space.

[00:48:20]>> Well, I think you guys know a little bit more than Fetsy now because I've explained it to you, right? There's a dogma and in the medical profession and the regulatory professions, um, it's interesting that you you get all these degrees and you have all this experience and then at that point you're full. your brain is full and you say, "I have no more to learn."

[00:48:40]>> A little stuck. Yeah, I agree.

[00:48:41]>> And when some pipsqueak from the supplement company, even if he does have a PhD in an Australian accent, comes and says, "Wait a minute, you're not considering this and that and the other." They're like, "Um, you know, take him away. Don't listen to him.

[00:48:53]That's heresy."

[00:48:54]>> Well, I thought I used to think nutrition was a a hard science. Remember in the 90s when I went to school, like there was a food pyramid and like at the very bottom was like all your carbs and at the top very sparingly was a little bit of fat. And now I feel like they flipped the pyramid on its head and it's like things are have totally changed.

[00:49:11]Why? You know, it's just crazy that nutrition isn't a hard science. It's something that we're constantly learning and adapting to.

[00:49:17]>> It's a very soft science.

[00:49:18]>> So that's exactly that case where it's like, no, you need to expand your mind to see colostrum in the mother's milk um gets through the gut. You're making your own drug in the right matrix gets past the gut. So >> yeah, there aren't a lot of nutrition.

[00:49:32]Watching nutrition news is like watching a tennis match. You're going left to right to left.

[00:49:37]>> It's a little frustrating.

[00:49:38]>> Carbs are good. No carbs are bad. A fat is bad. No fat is actually good. Well, not all fats, some good fats. Like, it's just >> and it's a bummer that that this has a cumulative effect. You almost don't feel the effects of all these things until you're at 80 and then it's like, dang, I should have eaten more more fat so my brain had some fuel or whatever you get.

[00:49:54]>> Yeah. Is cholesterol bad or good? Should we be lowering the best decisions you can? I think going natural is always the safest to make.

[00:50:02]>> Yes. And for all of you guys listening to the podcast, I think I've said this before, go and Google or go to YouTube and look for the time travel nutritionist.

[00:50:12]>> Oh, >> it is absolutely hilarious. A guy comes from the future and tells people how to eat and he comes back like every five minutes going, "Wait, >> no, eggs are bad.

[00:50:21]>> Forget what I said.

[00:50:22]>> Eggs are the best." Like remember that egg yo-yo? Goodness gracious.

[00:50:25]>> Yeah, it's still going.

[00:50:27]Okay, we have we only have 10 minutes and I thought well let's just answer maybe one question before we start talking nerdy to me. So, um >> my favorite part.

[00:50:36]>> What's the next question, Crystal?

[00:50:39]>> What are some of the most common mistakes you see people make when starting peptides?

[00:50:44]>> Yeah. Okay. So, again, we're talking supplement peptides, the oral peptides, the ones that have been clinically studied that we have, right? Whether it's in fit or lean or um our other products like Energized. Okay. I think that the most common mistake that I see is um relates to expectations.

[00:51:01]>> So we see almost miraculous impact when you have some of these drug injectable peptides, right? You take a GLP1, it really shuts down your appetite. So they'll take lean and expect it to be just as potent. It's not potent because it's not synthetic and it doesn't have a super long halflife. It works with the body. So, I think that um the take-home message is they're not drugs and the peptides don't replace the work, but they do help your body respond better to it. It's a much more sustainable approach.

[00:51:31]>> Yes. Yes. I mean, I know for myself, I was trying to build muscle on my own at 50 and every time I went for an inbody scan monthly, I was like, "Oh, I'm just staying the same. Oh, I'm just staying the same." I'm doing my same work consistently taking the fit peptide. And whenever I see that creep up every month, oh my gosh, it's like the biggest celebration because I've made muscle.

[00:51:54]>> Yeah.

[00:51:54]>> It is really hard to do that on my own at this point, I think.

[00:51:58]>> Yeah.

[00:51:58]>> And so, but it's not overnight and it's not quick and it's not without some of my own personal effort.

[00:52:03]>> But to have an assistant, to have support, it's finally seeing the number creep up. It makes me so happy. Yeah.

[00:52:09]>> And I want that engine in there so I see the body fat number go down. It's kind of hovering. I'm on you. I'm ready for it to go down.

[00:52:15]>> Yeah. We're becoming quite the fit couple, aren't we?

[00:52:18]>> I know. It's so fun. In our in our golden years, huh?

[00:52:21]>> Yes. Well, my golden years. You're not quite there yet, Crystal.

[00:52:24]>> All right. So, um here's the final question. These are from real people. I didn't make these up.

[00:52:30]>> Okay. Is there anything coming that you're especially excited about that you're able to share with us?

[00:52:37]>> Um death and taxes.

[00:52:40]>> They are definitely coming and I'm not excited.

[00:52:42]>> The inevitable. Yes. No. What else?

[00:52:44]>> All right. So, well, um, in terms of product, yeah, people are always trying to dig for some information. I've already talked a little bit about skin, right? That's out there. We're going to be having, uh, to looking into what peptides can do for your skin.

[00:52:57]>> So, topical.

[00:52:58]>> So, I'm going to shift angles a little bit rather than product. I'm going to talk about something that I'm excited about. What I'm excited about is, this is this is going to sound weird. Time and education. What I mean by that like in the 80s for example I was in I was doing medical research in the 80s that's how old I am and at the time um this scientist named Lester Packa was starting to talk about free radical biology and he even started a journal called um oh what was it called the oxygen I think it was called oxygen the journal it was so interesting because this is the first time in the context of nutrition and cell biology that scientists started talking about subatomic particles, right? We know that if you um like if you sort of hop inside a nuclear reactor, you're going to get burned and you'll you know irradiation will damage the cells. But we never looked at um this free radical biology from the idea of our own and from nutrition, right? So at that point um I was there and nobody knew what a free radical was. So like we'd be trying to explain it like well it's when you have a um a molecule that's short one electron and because it's short one electron it's going to try to find the electron dense parts of your body and steal an electron. So that would be a cell membranes or even the DNA itself and it's going to damage it.

[00:54:21]And then we talked about okay so you need something that quenches it something that is able to sort of lap up and provide those electrons >> your Pac-Man for this.

[00:54:29]>> Can you imagine talking about that with people that really had no concept >> that's big chemistry and orbitals and >> it was like watching Star Trek when they're talking about sort of paired quarks or or something. So um that changed right education gradually people started to understand that wow there are these plant phyitochemicals they're antioxidants these are really important there's sort of u you know free radicals are bad and here's how I prevent it >> and it impacts aging so I was there we but now like we've gone over that now we're living in this era of peptides I believe that peptides are going to change the world in terms of the human health paradigm right >> that uh and the shift has happened in the that's sort of fighting our biology, right? We're talking evolutionary biology, scarcity, activity. Um the farmer and synthetic peptides, I guess we owe them a thanks because they have elevated our um exposure to them.

[00:55:24]>> That's true.

[00:55:25]>> But as I said earlier, they're fire when they're synthetic. So don't get burned.

[00:55:30]Natural peptides are going to win the day.

[00:55:32]>> Just the word just the word peptide.

[00:55:34]People are like, "Yep, >> I want to know more about that."

[00:55:36]>> A year ago, people had no clue. And then like nine months ago, people like, I've heard of peptides. What are you doing?

[00:55:41]You've got a startup in peptides. That sounds interesting to me, even though I don't know what they are now. People are starting to understand. So, um, the gravitational pull will be towards the natural peptides. That's what I'm super excited about.

[00:55:52]>> Oh, I'm too. I'm excited to see what uh other things you can do for me with peptides.

[00:55:56]>> Yes. All right. So, we didn't get through all our questions, but it was really fun. So, it's time for chapter three. Talk nerdy to me, right? And with all of that talk of government regulations, it's really made me to want to talk nerdy. How many bureaucrats does it take to screw in a light bulb?

[00:56:12]>> H, how many?

[00:56:14]>> Well, this is not really a dad joke, but it takes six. One supervises, one arranges for the electricity to be shut off. One checks safety and quality standards.

[00:56:22]>> Oh my gosh.

[00:56:22]>> One monitors compliance with government regulations. And the fifth one fills out paperwork. And finally, uh, there's the one who screws the light bulb into the water faucet.

[00:56:31]>> Gosh, bureaucrats. That's awful.

[00:56:35]>> Um, actually guys, Crystal says that I'm obsessed with terms of regulation. And to prove her wrong, I went on a yoga holiday in Prague. It was a series of checks and balances.

[00:56:47]>> Nice.

[00:56:49]>> All right. So, there are even regulations in eightball. You know that?

[00:56:52]So, you know, if you sink the eightball, you lose the game.

[00:56:55]>> Yeah.

[00:56:55]>> So, yeah. There was a guy in Baghdad who sunk the eightball in regulation and his friend says, "Nice win, Ahmed. play again. And he responds, "Okay, but Iraq."

[00:57:07]>> Gosh, I don't know about that one.

[00:57:12]>> All right. Final. A doctor is calling in patients from the waiting room. And he says, "Well, due to new privacy regulations, we're not allowed to call in patients by their name. So, could the lady with the hemorrhoids please follow me?"

[00:57:24]>> Gross.

[00:57:26]>> Oh, that's awful.

[00:57:28]>> Oh my gosh. Well, Crystal, thank you for being a guest for free on tonight's show.

[00:57:32]>> Thank you for letting me come on the on the program and I love this community. I love peptides. I'm so excited for this area. I love that I'm married to you.

[00:57:40]You're amazing.

[00:57:41]>> You're a sweetie. You're just saying that because it's true. But you've done it again. You spent another hour with us. You've chosen science over scrolling, soul signals over cat videos.

[00:57:50]Those cat videos are so tempting, and peptides over procrastination. So, it's time for you to go and make a difference. And uh Dr. Allen will be ne back next week. And uh and if by popular demand you demand that Crystal come back and that we dump Dr. Allen, just let us know in uh and you can send us uh those comments to sciencemakewwellness.com.

[00:58:12]Thanks everyone and we'll see you next week.

[00:58:14]>> Thank you. Bye.