When non-invasive ventilation (NIV) fails and a patient requires intubation, the respiratory therapist must transition from rescue to control mode, prioritizing adequate ventilation (adequate tidal volume, appropriate rate, and CO2 clearance) over oxygenation alone, with initial settings typically including Assist-Control mode, protective tidal volume strategy, appropriate backup rate, FiO2 titration, and PEEP based on oxygenation needs.
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