The Second Opinion Rule | Jonathan Epstein, MD & Mark Moyad, MD, MPH |

Second opinions in pathology should be the standard practice rather than the exception because Gleason grading and other diagnostic markers rely on human subjectivity and the experience of the pathologist, meaning different experts may interpret the same slides differently; patients should advocate for their slides to be sent to a second opinion pathologist, as most insurance plans cover this service and turnaround times are typically 24-48 hours, providing both diagnostic accuracy and peace of mind.