Questions rise over the impact weight loss drugs may have on mood

追加: 2026-05-22

[00:00:00]GLP1s are transforming the weight loss landscape from Osmpic to Aggoi to Zepbound. One in eight Americans are now taking some form of the drugs according to a study in JAMAMA. Dave Knap, father of four, uses GLP1s to control his type 2 diabetes and weight. Shedding 53 lbs, but losing he realized something else.

[00:00:23]It was about 3 years in that I really started to discover that I was really not having the same amount of pleasure or seeking the same amount of pleasure in some of the activities that I once enjoyed.

[00:00:33]>> What was the first clue?

[00:00:35]>> Oddly enough, baseball was the first clue. I've always been an avid baseball fan. I've been a huge Cubs fan from the time I was born. And it's just always been something that I've followed very closely. And it was a couple of years into my GLP-1 journey that I really started to realize, you know, I haven't been following baseball at all.

[00:00:54]>> A problem obesity specialist Dr. Christopher McGawan is hearing from a growing number of patients. So, this lack of enthusiasm is not just in people's heads. It's a little unclear how frequent it's actually occurring because this was not studied in the original clinical trials, but what patients are telling us is a general decrease in interest, in joy, or in pleasure in activities that they previously enjoyed.

[00:01:20]>> McGawan says the drug may need to be paused or the dosage lowered. He also tells his patients to look for new fulfilling activities, especially