L-48 -NIPER JEE 2026 | Pharmaceutical Technology: Tablet - I | 360 Series #niper #tablet

Added: 2026-06-03

[00:00:03]How many questions have been asked from the Tablet chapter in the previous year Sniper exam and in this we will study two parts. We will do it not in one part but in two parts and this is part one question of the tablet where we are going to solve 30 important MCQs of the tablet.

[00:00:20]So you will quickly pay attention to all these questions one by one and try your best to solve them.

[00:00:29]So let's start with the first question: Excipients are used to promote the flow of tablet granules and powder materials by reducing the friction between the particles. It means between two particles. Ok?

[00:00:49]What do we call a substance that reduces the friction between two particles?

[00:00:52]Many times we have discussed this thing that what is glideant? What will be the lubricant? And what about antihydrants? So the job of glidents is to reduce the friction between two particles. The function of the lubricant is to reduce the friction between the die wall and the tablet wall.

[00:01:11]And the work of antihydrants is to prevent the punch particles from sticking to the punch and the die.

[00:01:20]This is the work of antihydrants. The job of all three is to reduce friction.

[00:01:25]But there is a difference. According to the question you have asked at this place, our answer will be C and where it comes for lubricant, we have to pay attention at that place also and where the antihydrators come from, we have to pay some attention at that place also.

[00:01:44]Ok? You can also see this through diagrammatic representation that before the flow there was very high inter particle friction. Later we added glides. They are very light. We use all the Aerosil, we put Cabosil Aerosil in it. And what will he do?

[00:02:04]Reduces the friction between particles. There is talc, silicon dioxide, aerosil, cabosil, we use all these as glide agents. Ok? Let's ask the question, the speed regulating device of the dissolution apparatus should be capable of maintaining the speed within the limits of the selected speed plus minus 10 minus yours is missing. You can add it at this place. I will also add it here. Plus minus is done plus minus 10 plus minus 3% plus minus 4% plus minus 5% Before this I have also made a digester of this and I would also request all of you that the digester which is still there in your work playlist, then go and click on all the digesters on the playlist and watch them one by one, if there will be any difficulty then you must watch them once, so the variation of plus minus 4% in the dissolution apparatus which is according to the apparatus has been told to you, you should also focus on the plus minus which is the rotation of the safe, the variation of plus minus 4% which is acceptable as compared to the USP, not only this, what about the steel, what will be the coating of gold, what will be the temperature, what will be the height from the bottom, you have to work on each and every aspect, revise it, the digester has been made and put in. Go and remember it once. Let's come to the next question.

[00:03:46]The Major Drawback of Super Disintegrate is What is the major drawback of super disintegrating agent? Changes color with time makes tablet the brittle hygroscopic in nature. High amount is required. There are a lot of comments about the super disintegrating agent.

[00:04:10]So your answer is absolutely correct. The biggest drawback of super disintegrating agents is that they are hygroscopic in nature. What are these substances? Are hygroscopic. Isn't it? Sodium starch glycolate, right?

[00:04:33]What are its crosprobidone, crosscarmilose sodium, these are examples of our super disintegrating agents and they are hygroscopic, that is fine, they can be absorbed with moisture.

[00:04:45]The enteric coated tablets are initially tested for the disintegration in this media.

[00:04:56]When we take the enteric coated tablet for initial disintegration, then in which media is it taken at that time? It can be taken in simulated gastric fluid, intestinal fluid, purified water or phosphate buffer whose pH will be six to eight, which will be alkaline.

[00:05:15]Son, you are being asked about this place initially, so when we take enteric coated, it first goes into the stomach, right? Now you saw Interic, it suddenly clicked in your mind that Interic. Well, interic means it will break down on alkaline PA.

[00:05:32]Hey brother, I have asked this question where do we get enteric coated tablets initially tested? So brother, the enteric tablet will first reach the stomach. After that it will go into the intestine. So we have to maintain the pH of the stomach.

[00:05:46]So the initial testing that will be done is done on our acidic PA.

[00:05:52]Later on we phosphate buffer that thing. are taken to alkaline pH. Be careful not to make a mistake at this place, you saw it and applied it, right? So even knowing that yes this is right, it will turn out to be wrong.

[00:06:07]Ok? Let's come to the next question.

[00:06:10]Function of Cam Track in the Tablet Manufacturing. What is the function of cam track in tablet manufacturing? The cam track truck will run, the truck will run and what does it do to us? Guide the Movement of the Panches. One is the turrets which hold the upper punch and lower punch from behind.

[00:06:34]That's turrets. A Cam Track Guides the Movement of the Punches. Option number B will be our correct answer. Ok? I have just told you that all this is easy. You can make a hopper, all this is easy. Cam tracks guide the movement of the punches. These serve to hold the turrets of the upper and lower punches from behind.

[00:06:55]Ok? And he will ask who defines the size of the tablet? So this happens because of the dye.

[00:07:04]The diffidence in dash of the tablet is called as the maling. Modeling is caused by which of the following? Due to change in the shape of the tablet or due to change in the flavour of the tablet, due to change in the thickness of the tablet or due to change in the colour of the tablet, the discolouration of colour that is happening in our tablet is due to variation in our colour.

[00:07:31]Option number D is our correct answer. I have done this many times.

[00:07:36]This one is the Malla tablet.

[00:07:39]This One Is The Non Motel Tablet. Meaning there is uniform distribution and look at this there is no uniform distribution. This happens because the colors are not mixed properly. Segregation happened.

[00:07:55]Ok? So modeling can be possible in such conditions.

[00:07:58]Modeling means the uneven distribution of the color. Next let's come to the next question. If the Cars index of the powder is 10% then the type of the powder flow is complete, I had made a table, Cars index was Hosner ratio was angle of repose, it is almost certain that the question will come, whether we will give it to you by angle of repose, by Hosner or by Cars index, then brother it will be 10, so the power of 10, the movie was very good, it was excellent, so I said excellent, okay, ₹1 means Pandit ji it will come below that, so you must be noticing the trick, maybe everyone is noticing, from 1 to 10, in 16 to 20 years, a person wants to look fair, wants to look good, from 21 to 25, he will study to pass the college and if he studies to pass, then brother you will remain poor, hence preparation for competitive exams is also important. You can also keep this thing in mind in Special 26 movie.

[00:09:06]Question number 8 is for the tablet made by the direct compression powdered field capsule when dissolution apparatus is mostly preferred is paddle apparatus, basket apparatus, paddle over the disc apparatus and reciprocating holder apparatus will be told quickly for the tablet made by the direct compression powdered field capsule when dissolution apparatus is mostly preferred is answer what will happen to it? The answer is the pedal apparatus.

[00:09:44]Ok? This happens because if we take a basket instead of the pedal and fill this capsule and run it in it, then there can be chances of clogging at this place.

[00:09:58]We only prefer paddle apparatus as compared to the basket.

[00:10:04]If we are talking about capsules then. Ok.

[00:10:07]Next let us come to the next part.

[00:10:10]Dashes are added to improve the appearance of the tablet.

[00:10:14]Flow Property Of The Granules And To Prevent The Sticking Of The Material To The Dies And Punches. We call it disintegrating agent or lubricant, binding agent or it is known as diluent. There should be no sticking and the flow properties of the dies and punches should be good. Acentragrating agents will add lubricant. Will add binding agent.

[00:10:41]Diluent is the binding agent, diluent is the bulk enhancer, disintegration is the breaker, only one thing is left for our lubricants, okay, to do the lubrication, that one is the fractional forces in the case of the loose powder are measured by the dissolution test, unity of the weight or disintegration test or the angle of repose, the fractional forces in the case of the loose powder are measured by the dissolution test. There will be unity of the weight, disintegration test, angle of repose also. Ok? This is a very easy question. Angle of Refuge What do we do with it? The flow of the border checks all these things. So the answer will be D. [sound of clearing throat] Next comes question number 11. Plating of the punch faces is done by. What do we use to plate the punch? We do it with chromium, zinc, iron or none of the above so that there is no sticking, to prevent the particles from sticking, we do chromium plating on it. Option number A will be our correct answer. Isn't it? We use chromium because it will be a hard coating. It is resistant to water. There is no rusting and particles do not stick to it. That's why we use chromium as compared to other metals. Ok?

[00:12:16]The Indian Pharmacopoeia weight variation for the tablet having the average weight of 150 mg. 150 mg.

[00:12:27]According to the Indian Pharmacopoeia. Now always pay attention whether USP is written or IP, then how much will come according to IP, in this 1000, our answer will be what will be 7.5, we will see the data, for 80 or less 10%, for 80 to 250 7.5% and for greater than 250 5% variation is our alloy, for the tablet, go ahead after looking at both this IP and USP, question number 13, delicate use for the manufacturing of the tablet containing the water sensitive drug. Which of these diluents do we use in water sensitive drugs? Is it calcium sulfate, lactose, mannitol, or all of these? Manufacturing of the tablets containing the water sensitive drug. The correct answer is calcium sulphate, lactose, mannitol or all of these. Answer: What will happen to it? The answer will be calcium sulphate. Ok? I have already mentioned that calcium phosphate and calcium sulphate of die basis will have very high concentration of unbound moisture and they also absorb very little atmospheric moisture.

[00:13:50]Question No. 14 Which is the most economical granulation process in terms of time, labour and equipment?

[00:14:02]Which type of granulation process is the most economical? Is it slugging, weight regulation, drive regulation or none of these? What will be the answer? See that one is the drive egestion process. That's why it won't wait, son. Two processes are going on at this place.

[00:14:23]First we sew it, then we dry it and then we sew it.

[00:14:30]So there is a double process in this.

[00:14:34]But in the dry gallation process, we form slugs, so slug son, this is not your gallation process. One part of it is slug. Slug means hard compact mass of dry powder. That is known as the slug. We took the slug and sewed it directly and finally our granules are formed. It is very easy. It is a single process.

[00:14:58]Two processes take place at this place. Ok?

[00:15:02]Slugging comes under this. What does slug mean? The compact mass of dry powder is called slugging.

[00:15:12]What do we do through Chilsonator High Compressor Machine? Let's compact the powder.

[00:15:17]Ok? That one is the slug and this is the process of it. Option number C was our correct answer. In the first stage of the waiting upon the addition of a gelling agent to the powder is characterized by one of the following: capillary stage, undular state, punicular state and droplet stage. Which of these is the first stage of waiting process when we are doing the gation process for the padders? PFCD PFCD.

[00:15:53]Ok? Answer: What will happen to you?

[00:15:55]PFCD.

[00:15:57]pendular stage, funicular stage, capillary stage and droplet stage. Look at this place, air bubbles are visible. Here the water and the pot got collected together. It ended abruptly here.

[00:16:11]Here it drowned in the water.

[00:16:13]Meaning that the flour has become wet.

[00:16:16]I had explained this to you by giving an example of kneading the dough.

[00:16:18]Ok? Let's get into the multistation punching machine. The upper punches as well as the lower punches are connected by the cam track. They are attached to turrets, wire messages, or revolving belts.

[00:16:42]We had already discussed the multistation punching machine. They are connected by the turrets. Ok?

[00:16:49]Which viscosity grade of the povidone is most widely used as the binder and tablet coating material. Which of these viscosity grades of Pobidone is most commonly used as a binder and as a tablet coating material K15 K6 K90 and K30 K15 K6 K90 and K30 Very good Very good Very good Answer will be given, son we use our K30, there are different grades of it [nasal sound] is it okay? So K15 has a low binding capacity.

[00:17:34]K30 is medium. That's why M4 for Medium and M4 Most Widely Used are used as a binding and coating material. That's why we also know K30 as the King of Tablet Binding. To K30. So option number D which is our K30 that one is the correct answer disintegration time for the sugar coated tablet what will be our disintegration time for the sugar coated tablet? One, the table which was given, the complete disintegration time of uncoated, coated, dispersible tablet, effervescent tablet, revise it thoroughly once, our answer will be given, here the disintegration time of sugar coating, that one is the 60 minutes, I was talking about this tablet, I was talking about this table, dispersible tablet, three now 5 minutes for less effervescent tablet and less uncoated according to the IP 15, for film coated, 30 minutes for effervescent tablet, 60 minutes for sugar coated.

[00:18:50]Next comes OpCoint. The color concentrate for the film coating is known as Opalux. So I told you that The Sugar. Lux soap is made of sugar. I tried to tell you something like this through a trick, Opalux Sugar Opa Spray Opa Dry and D, so I have selected one from these two, you have to tell me what will be the answer to this, you have told absolutely right, it is absolutely correct answer, what will be the answer to this, the answer will be B. Lux means sugar coating concentrate, film coating Opa Spray and Opa Dry is a film coating concentrate, okay this is color and this complete film color concentrate, we know this coating concentrate by the name of Opa Dry.

[00:19:41]Next come diclofenac tablets coated with the cellulose acetate phthalate administered to a patient will release the drug in the tablet of diclofenac sodium. And if we have applied a coating of cellulose acetate thiolate on it, then tell me where will the drug be released? Will it be in the stomach, in the oral cavity, in the liver or in the small intestine?

[00:20:10]What will be the answer? Small intestine is the inter coated will be. So it degrades by going to basic PA and by doing it this way it will not happen in our stomach.

[00:20:21]Cellulose acetate or phthalates are insoluble in acidic PAs. As soon as it comes into the alkaline medium, it is at acidic alkaline pH or neutral pH, the layer above it starts degrading and what will happen finally? The drug will be released. Question No. 21 The uneven distribution of colour on the surface of the tablet is non-edge ticking, melting, lamination and chipping. Just now we had a discussion on a question that if there is an uneven distribution of colour then we know it as malting.

[00:21:01]Option number B will be our correct answer.

[00:21:05]Next comes the materials where the fracture suckers across the grains.

[00:21:12]Stronger tablets will be form from small granules, large granules, both small and large granules and none of the above. In the materials where the fracture suckers across the grains, stronger tablets will be form from the small granules. Answer kya hoga beta humara small. Earlier also we had told that small granules can make more stronger tablets.

[00:21:42]This will happen because when the particles are smaller, their surface area will be more. They will also be compact among themselves and will have small areas.

[00:21:54]As you can see in this, the larger particles will have less contact area. It will be more here. That is why what are the tablets that will be made from small granules? They are stronger. It will also be difficult to break them apart as compared to the larger ganules. So smaller granules option number A will be our correct answer.

[00:22:19]Question No. 23: Which one of the following drugs is available as the tablet triturate?

[00:22:27]Which of these drugs is available in tablet triturate form? Adrenaline hydrochloride, theophylline, nitroglycerin or digitoxin.

[00:22:41]Which of the following drugs is available as tablet triturated ephedrine, theophylline, nitroglycerin and digitoxin. So, we make the nitroglycerin patches by triturating them.

[00:22:55]Our option number C is correct.

[00:22:58]Which of these drugs? So we make tablet triturate from nitro glycerin.

[00:23:04]Ok? Which we use as angina pectoris.

[00:23:09]However, the use of tablet triturate is negligible as of today. The tablets we make are made through the process of alkalization. Ok? So the answer will be our nitroglycerin tablets.

[00:23:25]Question No. 24 Quickest way to reveal the capping and lamination problem in the tablet is to find out which of the following is the quickest way to reveal the capping and lamination problems? Will do reliability test.

[00:23:44]We can test its hardness. Can we do weight variation or disintegration? Son, trituration means that in earlier times, the medicines which were made, we used to go to quacks and doctors and the tablets were made by trituration process, that is, by triturating through the mixing process, mixing water pistol, etc. That one is the saturation process, son, it is the quickest. The feasibility test question is about capping and lamination. So just think what happens in capping and lamination.

[00:24:22]In capping and lamination, air is entrapped. We have used deep concave punch. The moisture gets reduced, which means that the tablet can break easily. So, to find out whether it is capping or lamination, check its breaking. We do friability test in advance.

[00:24:43]In friability, we measure the strength of the tablet. We will pass it from a height and drop it. We will pass through a height of 6 inches and 15 centimeters and drop it.

[00:24:55]What will happen by doing this? If our tablet falls and gets damaged, it will break apart easily. So if we want to detect capping and lamination then we perform feasibility test through which it can be detected. Option number A will be our correct answer.

[00:25:16]I had also told you about this thing that it is revolving and this tablet might be breaking. Question No. 25 A mixture of bee wax and karnama wax is used in the sugar coating process.

[00:25:34]What do we use wax for sealing while sugar coating? Do you do it for colouring, subcoating or polishing? So wax is used only for polishing.

[00:25:46]Option number C will be our correct answer.

[00:25:49]Ok? The pedal over the disc is an USP.

[00:25:54]According to which apparatus is the pedal over the disc called? From this place you always get questions from the Dissolution Apparatus and with the help of the cycle I have told you many times through tricks that if the cycle is moving then there is a handle, then there is a pedal, then the chain of the cycle is moving, then its disc will come at the back, its cylinder is kept on the carrier at number six and the holder of the cycle is kept at number seven, our option number D will be the correct answer. It has been asked many times. Not once, with the help of this bicycle I told it not once but 25 times. The basket is paddled. Reverse cylinder Reciprocating cylinder. At number four, this bicycle chain is flowing. At number five is the bicycle disc.

[00:26:48]This cylinder is at number six. And the cycle has to be held at number seven.

[00:26:51]According to this you can take care of it. It is very important and questions always come from this place.

[00:26:59]Question No. 27 The diameter of the mass apparatus aperture in the IP disintegration apparatus is given below. Choose the correct size.

[00:27:10]I have made a digester for this also. Even before this you can go and see it.

[00:27:16]Disintegration and dissolution apparatus. So what will be the mass aperture at that place? 2 mm 4 mm 1 mm and 1 5 mm what will be the answer? What will be the answer son? A that one is the 2 mm is 1.8. Although exactly the edge is 2 mm according to the USP 1.7 according to the IP 2 mm.

[00:27:44]Which of the following is the antidepressant for the tablet?

[00:27:50]What do we use in tablet form as an antihydrant? Mineral oil, magnesium esterate, lactose, or PG as an antihydrant. The job of anti-hydrants is to prevent any particles from sticking to our punch.

[00:28:05]No particles should stick to the dye.

[00:28:11]What do we call the person who reduces the friction between them?

[00:28:13]Antihydrants. The answer is magnesium sterate. Ok? Which is also used as a lubricant. Correct? Option number C will be our B will be our correct answer. The remaining options do not fulfill that thing.

[00:28:27]Question No. 29 In the tablet coating process, inadequate spreading of the coating solution before drying causes the orange peel effect, stick effect, blistering effect and picking effect.

[00:28:49]Inaccurate spreading occurred during tablet coating.

[00:28:52]Inert spreading of coating material is taking place.

[00:28:56]So what do we call this defect? We will call this defect orange peel effect. Option number A is our correct answer.

[00:29:08]Ok? Orange Peel Effect.

[00:29:13]Next comes Chilsonator is used as What do we use Chilsonator for? Chillsonator is used for coating of tablets, filling of capsules or counting of capsules or as a tablet gunnulator machine.

[00:29:37]Chillsonator So Chillsonator compressor machine for slugging, for slugging process we do it in dry granulation process. If not in the coating then what will be the answer? D That one is the tablet granulation process.

[00:29:56]If you want to see this instrument, you can also see that we use Chillsonator Compression Machine in the dry gravity process where we will form slugs through high roller compactor.

[00:30:12]We can make this seat like a ribbon.

[00:30:15]And then what can we do about it? By breaking them, granules can also be formed. This One Is The Chilsonator Compressor Machine. Ok?