Can COVID-19 Directly Increase Pain?

Added: 2026-05-07

[00:00:00]Can a viral protein directly alter pain signaling at the level of peripheral nerves?

[00:00:07]As clinicians, we often encounter patients who report persistent pain after COVID-19.

[00:00:14]Yet, the biological mechanisms remain unclear.

[00:00:17]Understanding whether SARS-CoV-2 can directly modulate nociception has important implications for managing chronic orofacial pain.

[00:00:27]One important clinical question is whether SARS-CoV-2 infection can directly contribute to the development or persistence of pain through effects on peripheral sensory neurons.