What about that one study on LDL or Cholesterol? #data #science #research #cholesterol #ldl

Added: 2026-06-03

[00:00:00]What about that one study? How many times have you been talking to some friends and you tell them LDL causes atherosclerosis and they go, "What about that one study? What about that one study?" So, here's the thing about science and research.

[00:00:09]When you have that one study, there are people out there to try to prove you completely wrong. So, they will design a study and a protocol and a methods and a results and a study that is so well done that nobody has any questions anymore.

[00:00:21]Without any any shadow of a doubt, you want to be absolutely right and you want to prove them absolutely wrong. And that's what Ference did with his study.

[00:00:30]They took all of the studies. So, anytime you hear one of these carnivore or med influencers on here or whatever saying, "Well, there here's one study that looked at 300 people or here's a study of 50,000 people and here's one study and one study and one study."

[00:00:43]Ference looked at all of the studies. I always talk to you guys about looking at the totality of evidence. Look at the totality of evidence. What does the totality of evidence say about LDL? They looked at people with genetically very low LDLs, people genetically really high LDLs. They looked at everything in between. They looked at people whose LDLs weren't genetic, but we gave them high LDL and high uh cholesterol. They looked at 2 million people and all the studies they took all the studies. It was over 2 million people with over 20 million person years of follow-up. Now, if you don't know what person years means, you probably shouldn't be looking at studies. But that over 20 million years of person follow-ups and they proved with absolute certainty that LDL causes atherosclerosis. It's not a debate anymore. No one is sitting around here wondering, "Well, you know, there was this one study." There's no one study.

[00:01:30]This looked at all of them. I'm going to put it up for you. This is the study to end all studies. European Heart Journal of the European Society of Cardiology.

[00:01:37]This is the title you want to be looking for. Brian Ference and his group did the study to end all studies.

[00:01:44]And this is the final result. Whether you looked at genetic problems, whether you looked at we raised their LDL or we dropped their LDL, primary prevention, secondary prevention, this is the study of all studies. Over 2 million people with over 20 million year person years of follow-up. Every single time you lowered LDL, you had a significant reduction in atherosclerosis, cardiovascular disease, death, mortality, non-fatal MI, MI, strokes, whatever. Exactly aligned, straight line. Whether it was primary or or secondary prevention, the lower the LDL, the less chance of dying of something cardiac. So, don't come at me with there was this one study. This is the study of all studies.