New drugs Part 2 -INICET MAY 26/ NEETPG | Medsynapse app by Dr. Nikita Nanwani

Añadido: 2026-04-29

[00:00:01]Hello friends, this is Dr. Nikita here, your educator, mentor and friend. And here we are to discuss the part two of the new drugs. The part one we have already discussed in another video. If you have not watched that, please watch it. It's very important for your upcoming exams. So we had already discussed the oncology related drugs. Uh just a quick correction here. Please make it in your notes as well that dostarly map is against PD1 not PDL1.

[00:00:27]Right? So that's a correction that I wanted to mention. So we have seen oncology drugs and multiple myoma leukemia neurology valid drugs is what we had already seen in part one. So what we would be learning now is about infectious diseases cardiovascular drugs endocrine valid drugs. So in infectious diseases and antibacterials the newer drugs dipotin remember like leopluxin cyproluxin it is it is sounding like that asin but it is not a fluoroquinolone. It inhibits DNA gyraase and topo isomerase 4 like fluoroquinolones also do that but this causes single stranded break in the DNA not double stranded and it is not a fluoroquinolone.

[00:01:11]So remember the mechanism of action is different and that is why it is active even against bacteria which are resistant to other fluorocquinolones and this is used in uncomplicated UTI. So jipoti dacin similar [snorts] to fluoroquinol like liofluxin jipoti dacin but different from that remember it is both t and d inhibiting that is your topo isomearase and dnagy inhibitor plasmy is a next generation like you have straptomy so m it is a next generation amino glycoside again used in complicated UTI dafluxasin fluxin like cyproflux fluxin or liofluxin.

[00:01:54]So L it is a fluoroquinolone which is active which has consistent activity against MRSA and it is used for skin infections. Remember dilafluxin delays MRSA infection so it is active against MRSA. Septarolin which sephalosporins are active against MRSA?

[00:02:14]Remember the fifth generation syphalosporins siftin and you have septtobol.

[00:02:21]So it is roal drugs which is active against MRSA. Remember with these drugs MRSA now I have drugs which will kill me. So sarolin and sephto berol these are MRSA active. Then you have newer tetracycansawy and sarcycl. So cyclcline these are tetracycline drugs. Omar remember it like mast cells respiratory system. Then you have iavocyc is for intraabdominal and sare cycl skin that is for acne. S for s for skin acne tuberculosis ptomined delaminate. What is the mechanism of action? Remember ma this is molic acid synthesis inhibiting drugs which are used and they generate free radicals is what they generate.

[00:03:12]Right? Even is acid inh also inhibits micolic acid synthesis but by a different mechanism and in INH it inhibits INHA which is important an enzyme which is in reductase is important for micolic acid synthesis.

[00:03:29]Prytominid daminate they generate free radicals. Ptominate delaminate micolic acid MA right NID tells you that it is nitroidol drug. Bidaquilin is ATP synthes inhibitor very very important remember A and B ATP va is bidaquilin coming to antimmalarials very important tephenocqueen like prime queen remember antimmalarial so tephenocqueen is a single dose radical cure when I say radical it kills the hypnosids so used for vivwax and oale tephenocquin like primmaquin you need to test the G6 PD status for this drug teapenoquin important single dose Medical care. Lena where again some virus which virus?

[00:04:15]HIV1. CAP it is acting as a capsid inhibitor and L for long acting. It is capsid inhibitor. Glorify map is respiratory one. RSV in infant is what it is acting as. For RSV you have glorify map. Okay. For that you have glorify map.

[00:04:36]Now coming to cardiovascular system uh and metabolics. So in cardiovascular we have this very important drugs nicandal.

[00:04:45]So nicorandal is used for angina.

[00:04:47]Remember it as nicorandal. Write it as nico is a potassium channel opener.

[00:04:53]Remember it's not a potassium channel blocker but opener. So it leads to basodo dilotation and decreases the preload and after load. Ranolasin N O L A write it as N A sodium late N A L A okay so ranolazin is the late sodium influx inhibitor by doing that it is decreasing the calcium and decreasing the cardiac work trasidin metaz remember it as metabolism making it zero so the basic fatty acid oxidation the p fox fatty acid oxidation is what it inhibits metabolism zero fatty acid oxidation zero it is shifting the metabolism to glycolysis which requires less oxygen so decreasing the oxygen demand. Then we have omicaptive a new drug. It is meiosin activator. So read it as cam is mac which is meiosin activator. M for meiosin AC for activator. So it is activating meiosin.

[00:05:49]So it increases the cardiac contractility in patients of heart failure with reduced ejection fraction but without acting on calcium. Right?

[00:05:58]Drugs like dobutaminera they'll increase the calcium but this is going to be without acting on calcium directly.

[00:06:05]Meiosine activator. Then we have sacubetril wartin. Wartin is arbs angotensin receptor blocker and sacubetril it is your nepriyin inhibitor. So arney combination welsartin sacubetril in heart failure patients it decreases mortality because nepriyin it increases the netri uretic peptides level and decreases the fluid overload causes vasod dilotation. So sakubitril plus wellsertin army combination. Coming to endocrine and GI typide like sema glutide that is your GLP1 drug. Tzipatide TIR it is two mechanisms by which it is increasing [snorts] in insulin raising. Okay it is insulin raising. So GLP and also GIP. So it it helps in increasing the insulin.

[00:06:56]It is incretin drug right dual incrretin by acting on both GLP and GIP. So it in decreases the blood glucose decreases the weight as well and recently it has been approved for OSA as well obstructive sleep apnnea. Loracaserin is serotonin. So 5HT2 that is serotonin agonist 5 HT2C which suppresses the appetite. Set milanotide. Milano is your Milano cotton for agonist and by doing that it treats the obesity in barded beetle syndrome. Then you have sarog glitterazar remember like glitter zone pioglazone ros glitterazone but this is glazar. So similar to that drugs it is acting on pp gamma but also pp alpha. So remember saro acts on sara pp that is alpha and gamma both. So it is alpha and gamma both. So basically it will act in diabetes also and alpha is for fats.

[00:07:56]Remember ppr alpha is for fat. So it acts in diabetes also. So diabetic dis lipidmia is what it is acting upon and treats the nld non-alcohol fatty liver disease nash and also hypertrigidia.

[00:08:12]Tigoprazan like your pantoresol. So presants which are used for presols which are used for acidity. GD the reflux disease. The difference here is to prescap that is potassium competitive acid blocker and this operates independent of meal timing. It surpasses even your PPIs, proton pump inhibitors.

[00:08:34]This is PC cap tigraan procaropide like you have IDs which we have discussed in short short course on metanaps app the electron transport chain inhibitors ID drugs like cyanide carbon monoxide they are etc chain complex 4 inhibitor similarly this eyid is your 5HT 4 agonist which is used for constipation okay tenapenor nap na and p it is sodium and potassium exchanger inhibitor Okay, this is also used for constipation. Tinapenor imunology dupillumap due is di interlucans IIL. Remember interlucan switch interlucan 4 and 1 + 3 is also four. So four and 13 both of these are important like interlucan 4 is very important for Ig switching right and 13 also has a role in it. Both of these cause TH2 cell activation allergic diseases may role here. So these are used in urticaria attopic dermatitis where there is role of IG dupillimab secanumab remember s e s 17 va it is interlucan 17 inhibitor used in zorasis mikisumab interlucan 23 remember mi is like biri batup 2 re is three that is 23 inhibitor used in IBD inflammatory bowel disease fettoeran saran is s I RNA while drug it is acting on anti-throen decreasing anti-throbin so increasing the thrombin level promoting the clot formation in hemophilia A and B so bleeding may clot formation help fitan then you have nippocalumabocalumab is FC receptor while blocker the IGG FC receptor blocker so preventing the IG the antibodies generation in myastthenia gravis you have nepoalap nippo Focali map right so that was about the part two of the new drugs we have many more such tricks and all subjects preparation for nepgmg ICT on metanaps app by Dr. and Nikita we do have a lot of free pneumonics videos also there a lot of free like free test of the day also going on so please make sure you make the best of those resources available on metsanaps app and you have a dedicated shortsh short course like in the last meetpg we had around 155 from 200 questions from those just 80 hours of content the short and extra edge on medsaps app the pdf of this you can download again from metsignaps app I'll be putting the link in the comment section as well and in the description.

[00:11:15]So you can download the PDF for this and do not forget to revise this before your exam. Thank you so much. That was for today.