Obesity is a chronic disease that requires ongoing medical management, similar to diabetes or hypertension; clinical trials show that patients who stop GLP-1 medications like Ozempic typically regain most of their weight within 18 months, even when continuing lifestyle changes, because these drugs fundamentally alter physiology including food preferences, gut bacteria, and neurohormonal responses to food.
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What Happens After You Stop Ozempic? #shortsfeed #trendingAdded:
Now, the data is definite. Within 18 months of stopping GLP-1s, patients regain most of the weight. Trials like STEP 4, SURMOUNT 4 have shown rapid rebound.
Now, here's my question to you. Where does this leave bariatric surgery in the conversation? Are you seeing patients walk into Sir H. N. Reliance, walk into Digestive Health Institute who tried Ozempic, plateaued, stopped, and saying, "Doc, I need the sleeve or the bypass now." So, you know, when we uh in medicine, when we treat chronic diseases, it's always about how do you tackle it. So, the analogy of cancer, you've got radiotherapy, you've got chemotherapy, you've got immunologics, biologics, and you've also got surgery.
So, when to pick what? Bariatric surgery remains a very important member of treating obesity, but so do these drugs.
Uh for example, if you've regained weight after bariatric surgery, these drugs are very, very effective, in fact, twice more effective than they would be if you did do it without the surgery.
And for those who don't want to do surgery, maybe you could try these drugs. Remember, right, because it's a chronic disease like diabetes, like hypertension, like uh heart ailments, you don't stop the drug.
Obesity is a chronic disease. The longest trial, like you mentioned some of these trials, uh have 5-year results, and when patients do stop this drug, there is a chance that they will gain back, even if they continue lifestyle changes, even if they continue everything. So, if you think that you can use it for a short period of time and then watch your diet, no, because it's all about your biology, your physiology, which we've not yet understood about obesity.
Obesity is not just a simple word, calories in, calories out. No, this drug changes a lot more other things. It changes uh your preferences for food. It changes your gut bacteria. It changes the way your neurohormonal responses go to what you food you take and how you react with that food. So, I do believe that it is a chronic disease, needs chronic management. The day you stop this drug, there's a very good chance you'll regain weight.
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