Prokaryotic DNA Replication Made Easy 🧬 #molecularbiology #education

Added: 2026-05-18

[00:00:00]I am bacterial DNA. Watch how my entire circular genome gets copied.

[00:00:04]>> I am DNA gyrase, here to help relieve the twisting stress that builds up within the circular chromosome during the process of cellular replication. I am helicase, binds and prepares to open DNA.

[00:00:14]>> We are single-stranded binding proteins, stabilizing the exposed single strands.

[00:00:19]I am primase, laying down a short RNA primer. I am DNA polymerase 3, initiating the new strand. I am beta clamp. I hold polymerase firmly onto DNA.

[00:00:33]I am DNA polymerase 1. I remove RNA primers and replace them with DNA. I am DNA ligase. I seal gaps between DNA fragments.

[00:00:45]I'm replication fork. This is where all the copying happens. It is quite a busy place with all of my friends working hard on the DNA strand today.

[00:00:53]We are the replication team. Together, we copy bacterial DNA accurately.