Humans possess the same limb-regeneration gene cluster (ERK) as axolotls, but a silencer protein called p21 blocks this pathway at birth; while Harvard researchers successfully reactivated ERK in adult mice to regrow severed fingertips in 28 days, the same p21 protein also prevents cancer, creating an evolutionary trade-off where organisms must choose between regenerative ability and cancer prevention.
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Scientists Find Gene That Regrows Limbs Like Salamanders Do #Shorts追加:
Your body had limb regrowth genes.
Evolution turned them off 300 million years ago. The myth, mammals lost regeneration because we evolved past it.
The truth traces to a single genetic switch. Axolotls regrow spinal cords, hearts, even brain tissue using a gene cluster called Erk. Humans carry the same cluster, but a silencer protein called P21 blocks at the moment we're born.
>> [music] >> Harvard Sinclair Lab reactivated Erk in adult mouse cells in 2023. Severed fingertips grew back in 28 days. But here's the part no one's saying yet. The same gene that blocks regrowth also prevents cancer. Turn it off and tumors explode. We can regrow a limb or stay cancer-free. Evolution picked one.
Follow at Brainy Whiz Bros. Tomorrow's gene is even darker.
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