In monophasic liquid dosage forms, solubility classification according to USP standards defines 'soluble' as requiring 10-30 parts of solvent per part of solute, while 'freely soluble' requires 30-100 parts. During syrup preparation, excess heat causes inversion (hydrolysis of sucrose into glucose and fructose), leading to increased viscosity, fermentation susceptibility, color darkening, and reduced sweetness.
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Monophasic Liquid Dosage Form | Pharmaceutics | GPAT 2027 | Class - 10 #gpat2027 #gpatexamAdded:
Hello everyone a very very good evening brother.
How are you? How is everyone? Welcome back in today's class champions.
Come quickly to today's class. Yes, preparations for JEE Main 2027 and 28 have already started. And here today we will talk about this in our 10th class i.e. class number 10. All the questions related to monophasic liquid dosage form of pharmaceuticals are asked or have been asked in your GPAT exam. Yes.
And this class is going to be updated by 2026. That means, in these classes, we are also going to discuss the questions asked in GPAT 2026 from this topic.
Ok? Everyone join quickly and we will discuss everything and before discussing the class, let me tell you here that the children who have joined for the first time, must download the Pharmacy India mobile app.
For your preparation, the video lecture of this GPAT lecture that you are watching as well as its PDF will be available to you on Pharmacy India mobile app. Ok? Due to which your time will also be saved. Ok? Pharmacy will be available on India app. Remember, your preparation will be even better. Ok?
So let's go, you are already connected to the WhatsApp and Telegram group. Ok? If you have any query related to any exam, GPAT related, preparation related, then you can contact on this given number to make your preparation even better, okay, let's go and join the WhatsApp and Telegram group for latest updates, let's go, the first question is here on our screen, according to the USP, according to the USP, if one part of solute is required, 10 to 30 parts of the solvent, it is described as according to the USP.
Look, there is a solubility table. There is a solubility table. Regarding that solubility, the question asked here is how much of it is related to 10 to 30 parts per million and in which category will it fall? Slightly soluble, freely soluble or soluble. So let me tell you here that if it comes to 10 to 30 parts, then that is your solubility. Ok? 10 to 30 parts look VFS ok? VF S Dekho Yahan Par Bolo Na Very Very Soluble Fine Freely Soluble Sprungli. Ok? Remember, Sprengel soluble is 10 to 30 to 100. Ok? Soluble is your 10 to 30 parts for one part of solute.
Ok? Remember this. Solubile is the correct answer. So is it clear here? Solubility term defined. Okay, look, let me tell you this thing here and make it clear.
Solute means your sugar. Solvent means your water. Solution means a mixture of both. All three terms are different. Solute, solvent, solution. Similarly, suspension emulsion is different. A suspension consists of a solid and a solvent.
Remains liquid. Both are biphasic in emulsion.
Both are liquids. Oil and water. So these things are talking about monophasic, right?
So here we will talk about single fuzz. Ok? Next is what is the negative result of inversion caused by excess heat in syrup preparation? It's a simple thing. If you are making syrup. So what will happen in case of inversion in negative result? The viscosity of the excess wheat will increase until the syrup solidifies. Syrup becomes susceptible to fermentation and darkens in colour. Ok? That means its color will start becoming dark. Ok? Either the sucrose will crystallize out of the solution immediately or the syrup will become less sweet. So remember, whenever you mainly give excess heat, you will give excess heat to something, understand here that if you will give the excess heat, then what happens, you must have seen that it becomes like burning, it starts turning brown, it starts becoming dark, so yes, what will happen with the syrup, fermentation and darkening, its colour will become dark due to excess heat, so this is the correct answer, just say this, see, table sugar, if you give it excess heat, then inversion will start happening.
Ok?
Hydrolysis. Ok?
What does hydrolysis mean? Hydro means water.
Hydro means water. It's a simple thing.
What does lysis mean? Lysis means breakdown.
Break down due to water. Breakdown due to water. Ok? Remember this. You told me what is happening in inversion?
Hydrolysis is taking place. Sucrose into glucose and fructose. Excess heat means it is caramelizing it somewhere.
Ok? It is making its color dark.
Ok? So remember that is why it is called excess heat. Controlled heat should be given.
After that, next is what will be springily soluble according to USP?
Again, we can see the solubility table as very important in itself.
Springily soluble refers to how many parts of solvent dissolve one part of solute. Ok? Springily soluble means it is a simple thing. 30 to 100 springy soluble is mentioned here.
30 to 100 is okay? Here it is said that 3200 soluble 10 to 30 parts. Ok?
Slightly soluble 10 to 1000. Ok?
Remember this is a table. This is a table.
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