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MCCQE Osteomyelitis + Review of Medbuddy Question bank

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347 views8likes1:47:24medcognitoclassOriginal Release: 2026-07-21

Osteomyelitis is an inflammatory bone infection that can be acute (days to weeks, responds to antibiotics) or chronic (months to years, requires surgical debridement). The most common organism across all age groups is Staphylococcus aureus (MSSA more common than MRSA), with specific variations: Salmonella in sickle cell disease, Pseudomonas in IV drug users, Group B strep in neonates, and polymicrobial in diabetics. Clinical presentation includes fever, localized bone pain, and decreased mobility. Diagnosis involves CBC, ESR, CRP, blood cultures, and imaging (X-ray first-line, MRI gold standard). The probe-to-bone test is highly specific for diabetic foot osteomyelitis. Treatment requires 4-6 weeks of antibiotics (6 weeks for vertebral involvement), with surgical consultation for exposed bone, abscess, or neurologic compromise.