GLP-1 medications like tirzepatide (Zepbound/Mounjaro) work through a lock-and-key mechanism that binds to receptors without wearing out over time, meaning they do not stop working as receptors do not become desensitized. Clinical trial weight loss percentages (such as 20% average weight loss) represent the average across all participants, not the maximum possible loss, and individual results vary significantly based on factors like starting weight, adherence, and lifestyle. The 15mg dose limit for tirzepatide was chosen for safety and efficacy balance, though higher doses are currently being tested for diabetes patients. Weight loss plateaus are common and can be addressed by varying calorie intake, while maintaining the medication helps prevent the return of food cravings.
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Deep Dive
Can GLP-1s Stop Working? The Truth Might Surprise You. Weekly Weigh-InAdded:
Hello and welcome to the downsized. It's Friday, May 29th.
>> That is correct.
>> Is that right? 2026. And this is a channel where we talk about weight loss and all things related to GLP1 medications. My patio table of 30 plus years. Hopefully we'll will hold up through this video. I've lost over 50 pounds on trappepide and this is this is our time where we talk about what's going on with us and then we also answer questions from you our viewers. So, welcome back.
>> What do we call that time?
>> It's the question and answer time.
>> No, what is the actual name of this series?
>> Weekly weighin.
>> Thank you.
>> Where we get to weigh in on our questions.
>> Yes. And this is my husband, Christopher Durham.
>> That's me. We got all kinds of fun stuff to talk about today. Of course, bridge initiatives coming up. We've got side effects. We've got how tall Lraine is is one of the questions. All kinds of fun.
>> All kinds of fun things. I I laughed because I'm like, she says this every time.
>> If you're an old viewer, go ahead and put my height right into the comments right now. Okay.
>> There's like a whole drama about her height. Yes, >> sir. Anyway, so the way this works is we'll talk a little bit about our our we'll talk a little bit about our week >> to begin with how our weights were just how the whole GLP1 processes for us and what's going on in our lives and then we'll take questions from you. If you're one of those people who think I don't care about their lives, >> I don't care about Lorraine and Christopher. I want the questions. I just want the information right now. I appreciate you. And like and subscribe this minute because we are here for you.
It'll be here about 20 minutes from now after she finishes rambling, but that's okay. You can advance forward. There's always chapters in the video. Yeah.
>> If you don't know how to do it, just scroll and you should see it'll pop up in the questions. You and you can go to the question that you're interested in.
>> If you'd like >> or just hang around just because we're, you know, >> just hang.
>> It's a lovely day.
>> There are there are little tidbits embedded in some of this stuff.
>> You never know when you're going to get one of our our little lovely tidbits.
It's true.
>> Sounds funny. All right.
>> All right. So, >> what do we do now?
>> Well, we talk about our week. So, did you weigh today?
>> I did weigh myself today. Let me let me pull up the receipts as the girls say, as the kids say. So, I weighed myself on my Hume Body Pod. We are sponsored by the Hume Body Pod. And today, the Hume Body Pod told me my weight was high.
Okay, human body pod, I don't need your analysis. I just need you to tell me the numbers. Thanks. But it does tell you the analysis, so that's fine. Today, my weight is 147.6.
It is a little high, honestly. Thanks, Body Pod, for pointing that out. My starting weight when we started back in September of 2023 was 193 pounds. I got as low as 138 pounds. And last year at this time I was sitting at about 145 pounds. So and I I like to be about 143 145. So 147.
Yeah. All right. Hume. That's >> what has been your average weight over the last >> 145.
>> So >> yeah. I mean I >> sounds like 145 is really where your body wants to be.
>> Yeah. I think I think so. However, you know, as people have, viewers have pointed out to me, you know, Lorraine, you do a lot of working out, you're building a lot of muscle. How is that affecting your weight? So, you know, looking at my other numbers, um, my body fat percent is 30%. Human Body Pod tells me for me that's standard. And my muscle mass, my lean mass today, is that today is 96.7 lbs.
So 96.7 lbs of that 147 whatever is lean mass, which I think is pretty good. So then I go back to what was my uh lean mass when I first got the body pod back in September, October of last year. So I go back to October of last year and it was 93.1 pounds.
>> So you're 3.7 pounds up in muscle.
>> So I'm three that's not really muscle though.
>> 6 lb up in lean mass which could be muscle which could be cardiac muscle which could be >> and tendons and thingsing but it's not fat. So, my weight has gone up about three pounds in lean mass since October.
Okay? So, this isn't an overnight thing.
But if I'm sitting here stressing about three extra pounds, maybe I should really look deeper into my body composition and know that I have put on some lean mass. And that's that's where it's coming from, right? because my clothes aren't fitting differently. You know, usually you gain five pounds, you're like, "Yeah, this might be a little tight." My clothes are not fitting differently. Um, and so that was that was something I wanted to look into. And also further on the body pod, I mean, yeah, on the body pod, uh, you can pull up, let's see, is there another is there another one that's a good um, skeletal muscle mass, 62.1 pounds of skeletal muscle, which have gone up about the same number of pounds. It's about four pounds. Yeah, 57 58.7.
Uh, so yeah, about four pounds. So, my muscle mass has increased 3 or 4 pounds since October. Now, it is really hard to gain muscle anytime, especially if you're a woman over 50, post-menopausal, as am I, right? Especially if you're in a calorie deficit, it's hard to put on muscle.
Really, if you're trying to put on muscle, you It's a little easier if you're in a calorie surplus. Okay. So, the fact that I've put on three or four pounds of muscle in the past what, like nine months?
>> You haven't been trying to lose weight anyway.
>> I haven't been trying to lose weight.
Uh, I've been trying to maintain my weight and I've also been working out a lot. I've put a focus, an increased focus on weights through my classes at the gym and through my I did some I did went and tried some pull-ups today. Uh, so you know, I'm I'm okay with the weight I am today, but because the body pod, even though it's telling me my weight is high, I can see that I've put on muscle through this time, it's not like my body fat is just getting out of control, right? So, that's encouraging.
>> And either way, if the weight your body wants to be at is one, >> I don't know. I don't know.
>> What has the average been over the last since you've been here?
>> 145. I mean, it was 145.
>> I was 145 exactly for like six continuous months.
>> So, that sounds like that's a comfortable place for your body to be.
>> Yeah, it's a it's a weight that I can maintain without really tracking calories, without really agonizing over every little thing that I eat. Um, >> I'm still on the medication. I'm still taking >> Even if you hadn't gained muscle. Mhm.
>> You're still within a standard deviation of 145 >> after we were on a trip for 10 days in Europe.
>> So, >> uh yeah. Yeah. I mean I we came home from we went to Amsterdam and uh Paris. We came back a week ago and I weighed myself. I was a pound less when we came. No, no, not not right after the day we flew, but the next day I weighed. And I was a pound down from the weight I was before we left. And that usually that usually doesn't happen, but I did I was I think I did pretty good with my eating. And we walked so many steps.
>> So many steps. Uh like 15,000 some days.
So that I mean, you know, it helps Yep.
>> That's my story.
>> That's your story.
>> Well, very And did you give all your statistics?
>> I am a 57year-old, 5 foot five, mother of three grown children, post-menopausal if anybody cares about that. Uh I'm also on uh I have a estrogen patch and a progesterone pill. Ladies, talk to your doctor about that if if you're in this age bracket.
It's very helpful. Okay.
>> Okay. Christopher Durham, 57 years old.
I started at 286.4 pounds. It's been two and a half years ago, now September of 2023, we started.
>> Took me about 15 16 months to lose 100 pounds. And today when I weighed, I was actually 187.4.
>> Oh, okay. Because you had been up a little bit, right?
>> Um, yeah. Yeah. But actually, I weighed the day after we got back and I was like, "Oh, don't do that."
>> Yeah. I I never like to weigh the day after >> the airplane. A 9-h hour flight is not good for you.
>> Fight was ever long. Ever long.
>> I was a couple of pounds up then and it's it's come back down.
>> Yeah.
>> So, you know, it's fine. I am 5 foot 10 and a half on a good day and I've been maintaining right around 185 pounds is kind of my my center weight that I want to stay at on a 15 milligram dose of deptide zeppelara. If you guys have watched I did a quick pin so I've actually gone back and forth on on >> compounded and branded a number of times over the last two years.
>> I'm on the 10 milligram dose. I didn't say that. And honestly, people were asking, "Did you lose more on the zip?"
Well, I wasn't I'm not trying to lose.
Number one, I'm trying to maintain.
>> Well, people always want to know if there's a difference.
>> And number two, I can't tell a difference to be quite frank. I just it if I didn't know I had done it in that pen versus the need, I can't tell the difference at all.
>> It all works the same for me, you know. I mean, I can tell you traveling in Europe, particularly France, and you you guys know I'm a foodie and I I love all of that.
So, I had a croissant. It was delicious.
Was we ate some good food. We didn't overindulge. We didn't do anything crazy. There was no, you know, $500 meals. There was none of that kind of stuff.
>> Was one crappy meal, but you know, whatever.
>> Was that the cheese fondue?
>> Oh, it was not good.
>> Fondue for two. Fondue for two. the fondue for two.
>> We were traveling with my youngest daughter who is pretty picky.
>> It's fondue for three actually.
>> Yeah. Who's pretty picky. So, we're we have to to work around her and make sure that she's happy because, you know, >> Well, we tried to go to the fondue place that was highly rated, but we didn't have a reservation and we just went there and they couldn't fit us in. So, we went across the street to another Fondue place that had like two people in the restaurant.
>> Was not good. And that wasn't that wasn't the greatest.
>> We had lots of fish, lots of fresh produce, and I was, you know, I did we didn't it was no overindulgence, but we I certainly ate more than I did do normally at home.
>> Yeah. I think anytime that we're traveling, we're eating more than we do at home. I mean, I think that's just going to happen. And that's not something that I'm too worried about because I think it's good to vary your calories and to, you know, have some low eating times and vary it with some higher calorie eating times. I think that's good for your body to kind of shake it up a little bit.
>> Yep.
All right. So, we have the cruise next week, >> right? So, the second annual downsized at sea cruise. The ship is officially sold out. So, I'd invite you to come, but sorry. Sold out. Sold out.
>> Now, it did not sell out because of our people. We have about 85ish people that will be coming. It's a several thousand person ship.
>> Was it like 3,600?
>> Something like that. Yeah.
>> So, we'll be selling out of Miami, Florida, Nassau, Bahamas. Stay tuned.
We'll be filming lots of stuff on the ship. There will be a weekly weigh-in from Miami.
and a weekly weigh- in from the ship will be all kinds of fun stuff going on.
>> All right, you want >> Well, it's I went to the gym this morning and one of my friends at the gym like loves to travel and she and her husband celebrated their 30th anniversary and they celebrated by going to Italy for 30 days. And she just got back and we were looking at her pictures. It just looked like a fantastic, fabulous trip. And she goes, "Lorine, you travel a lot, right?" I said, "Yeah, I'm going the cruise. We just got back and we're going on the cruise." She goes, "Did you mean to do those backtoback like that?" I'm like, "Well, that's kind of how it worked out." Yeah. She goes, "Well, how do you like recover and like get back into the groove of things once you get home?" I said, "You know, you just have to get back on your really clean eating, you know, water, fiber." I said, "Exercise, you know, you're here. That's great." I said, "Um, sunlight is great. It's hard to." She's like, "I'm waking up at 4:30 in the morning." I said, "Yeah, I woke up at 5:00 in the morning today."
>> That's just kind of when I wake up now.
>> Well, and we're seven hours off, you know, and it takes >> It takes a week really. It takes an a day for every hour that you're time changing.
>> So, um, you know, but I think I think exercise is really key. I think sunlight is really key. So, you know, if you're going through some time changes like that, it uh, you know, let your nutrition kind of help you through that because, you know, if you're eating a bunch of sugar and a bunch of crap, you're just not going to feel good and that's not going to be helpful.
All right? Not that y'all are not, you know, you know, sometimes you get in that high eating mode and you come back from vacation and you're like, "Let's go out to dinner." No. like let's let's go to the grocery store and you know cook some nice maybe salmon in the air fryer or something like that. So got to have cut it off kind of.
>> Yep.
>> Yeah.
>> All right. Would you like to take some questions?
>> All right.
>> So this is the portion of our weekly weigh-in where we take questions from you, our viewers. If you'd like to submit a question, you can leave it under this video. Make sure you use a question mark, the actual punctuation mark, and YouTube will do magic things and sort out all the questions for me.
So, it makes my life easier. Otherwise, we get so many comments I I will not go back and figure out which ones are questions. I'll tell you right now.
>> Yeah, make sure you use a question mark.
>> So, let's start with Mary Millsler 6915 who asks, "I was told the needles do not come with the quick pen. How did you get them to include them?"
>> So, I recorded a video I guess a week or so ago of taking a zapbound quick pin shot.
It's an interesting question, Mary, because we have actually now gotten a couple of different quick pens and twice it came with the needles and once it did not come with the needles. I have no idea why that happened.
>> Uh I know they're being delivered by differenties by Lily. So Lily has aies that fulfill them for them >> and it may just be a function of the different pharmacy, but we didn't do anything different. You can actually order those needles from your local drugstore or Amazon if you need additional ones though. And they're only a few dollars. I don't think they're they're terribly expensive. Next question.
>> This is from PATH 6923. Hi, what's the price difference between compound and branded Mjaro, please? So, Mjaro is usually prescribed for type two diabetics. Zepbound is the same thing prescribed for weight loss and the name of the main medication is Tzepide. So Tzepide I get compounded Tzepide through my teleaalth provider which is Mochi Health. If you use my code and my link in the description of this video you can join Mochi and save $40 on your first month's membership fee. $79 a month membership fee that covers all your doctor visits, unlimited messaging of the doctor through the portal, and it also includes any nutritionist visits that you may want to set up to talk about, you know, what you're eating, and it's kind of like p personal coaching session almost with the nutritionist.
That's $79 a month. The compounders appetite is $199 per month, any dose.
So, it's not like some of these tellahalths where they lure you in with a low price and then as you go up in dose, the price goes up. No, every dose is $199.
It ships directly to your door. I'm actually waiting on a shipment right now. Um, and this particular pharmacy ships FedEx, so I can even track it on my phone, like where is it in transit and how how quick is it going to get here? Now, how much is the branded Zetbound or >> Well, Mjaro and Zetbound are two different conversations >> and that's why I started off talking about type two diabetes. So, if you're if you're in this for weight loss, this you what you're going to get is zbound.
If you're in this for because you're a type two diabetic, you're not going to a compounded pharmacy. you you need to work with your doctor and you're probably going to get insurance coverage for some kind of GLP-1 uh due to the fact that you're a type two diabetic >> and that could be as your cost could be as low as $25.
>> Yeah, I think uh like Mike on a mission says, you know, he's a type two diabetic and he doesn't feel lucky that that happened, but it is lucky because then he got coverage >> for his medication. So if you you can go to the Eli Liy website, there's an actual Eli Liy Mangaro site and an Eli Liy Zepbound site. We don't honestly follow the Mangaro pricing as much because that is and it's all the same medication.
>> Same medication, >> but it it's branded Mangaro. It's for type 2 diabetics. The Zetbound, I think, starts at $2.49 and goes up to $4.99. I won't get those numbers exactly right.
So, go to the go to the Zepbound website and you can see those things >> if you don't have >> if you don't have insurance coverage. If you do have insurance coverage, it could be as low as $25. And if so, hey, you won the lottery. Good for you.
>> Yeah. So, what you want to do is uh you know, call your insurance company and see what kind of coverage you have for obesity, GLP1 medications, or take the prescription, you know, and take it over to CVS or Walgreens and see what the price comes out to be. Sometimes that's really the only way to know. It's so hard to get through to somebody at my I think I hear the FedEx man pulling up.
Um it's so hard to get somebody on the phone at these insurance companies sometimes. But anyway, uh yeah, so your mileage may vary with the price. Now, um for us, it's the cheapest to do the compounded. So that's I've done 98% of my shots have been compounded shots.
Next question is from Jacqueline Walters 6811 who says, "Christopher, why don't you and your wife buy Part D as a standalone to get this savings?" She's talking about the bridge program. Then I did a video, >> right? And that's the answer, Jacqueline. We're not 65, so we're we're 57 years old. We don't qualify for Medicare at this point.
>> It it would be nice if we could get $50 medication, but we're we we're not eligible for it.
>> Get to 65. We'll have to see what the state of the union on these drugs is.
I mean, it'll be completely different by by that time.
>> What I would say is, and we get comments about this all the time of, well, I guess I'm just out of luck cuz I'm not old enough to qualify for Medicare of I celebrate every time anybody gets affordable access to these medications.
Anytime somebody that can treat their disease of obesity, their sleep apnea, whatever it is, they can do it. And these changes to Medicare and this test will hopefully roll down. Typically Medicare pricing is the leading edge and your insurance should follow if this if this proves to be effective. So >> yeah, so we're very interested in what's going on with GLP1s and Medicare even though >> we're uh you know my dental hygienist said to me, you know, what about what about me? I'm 55. Don't they don't they care about me? I don't care about Medicare. Well, the only reason, you know, we should care is because it has to start somewhere, right? If that coverage starts with Medicare, then eventually other insurance companies, like Christopher said, will follow. So, um, that's, you know, the same thing with the Treat and Reduce Obesity Act that's currently going around Congress right now. That would get that would uh make a law that says um Medicare can cover obesity medications.
This is from Rita Young. If you have chronic kidney disease, do you have to be careful with protein or water? That's a question for your doctor. I don't think we've said this in this video yet.
We're not doctors. Okay. If you have a chronic kidney condition, I don't know nothing about that. Right.
>> The answer is yes. The answer is yes.
So, there are standard recommendations around GLP1s for protein consumption and for water consumption. But if you have other medical conditions then yes there are concerns. I don't know much about chronic kidney disease but I I know the requirements are different. So please talk to your doctor about that.
>> Next question again on the bridge program popular. Kim Kelly >> says can our doctor log on and submit after our appointment in June or are they all going to try and log on to CMS on July 1st at one time? Thank you for the clarity. Uh the system does not open until July 1st. Your doctor cannot do anything, >> nothing to look at >> until July 1st. So the reason you make an appointment in June >> is such that you have a conversation with your doctor and your doctor has all the information they need that when July 1st hits, they are ready to go.
>> Yeah.
>> I suspect there will be a rush.
There will be a million people out there trying to get this done.
>> Kind of like getting Taylor Swift tickets on ticket master. Like be patient, right? It's probably gonna be, you know, it's gonna be a loted.
>> Yeah, it is. But no, your doctor cannot do anything until July 1st.
>> Two more questions on Bridge and then we're going to move on from Bridge. Ruby Pooh says, "I'm concerned with them not accepting enrollment until 71. How long will it take them to actually process the applications so that we can recognize the $50 price? August uh September? Who knows?" And Derell says, "How does Humana know where to send our prescriptions? Do you have any idea how long it will take for Humanana to process? I don't want per I don't want to purchase a quick pen if I'm going to have it 4 days later."
>> So, >> I plan for a 30 60.
>> Yeah, let me sit. Let me start with this. First of all, all of the information that is available is in the video.
I didn't hold anything back. If it's there, it's in the video. Uh, >> and that's just a couple videos back, right?
>> Yeah. Right. It would just >> please go back and watch it >> carefully yesterday.
>> Yeah. So, please go if you have questions about this Medicare uh bridge program situation, please go watch this video. Everything's in the video, >> right? And there is also a link in that description to the CMS FAQ for GOP1s that gives you all that information you can read yourself. Same information.
I've just made it a little more digestible. I'm I'm not making anything up. It comes directly from them. We don't know how long it will take is the answer. It just I can tell you I think there's a lot of people who have expressed concern about this and well, how long is it going to take? Well, is it going to go smoothly?
>> Probably not.
>> No matter what no matter what political party you're in, you you we all recognize that our government is not the most efficient or timely or anything like that. So, are there going to be road bumps?
>> Absolutely.
>> Absolutely. Plan on it.
>> Plan. You don't want to run out of your medicine, right? So, plan on it's going to take a month or two. Just plan for that now. And you know, if you have a few extra weeks worth of medicine, then God bless America.
>> I mean, the good thing about the quick pen is the bud dates on those are a long time. They're a full year out usually, so it's not going to go bad. Yeah, it's a little expensive to do it that way and you'd hate to have to buy one and then spend then their $50, but I'd rather you have your medication than >> be off of it for a month.
>> So, the Humana and the prescriptions question is your doctor picks where your prescription goes to just like every other prescription when you're sitting in the doctor's office and they >> pharmacy, >> right? And they they send it. So, Humanana doesn't actually send it. The Humana piece of it is really just a systems piece.
So there it's their computer system that's being used. I don't know that there's humanana people out there that are going to look at and I think what is going to happen and we'll see more when it rolls out officially is that there are criteria there's a system your doctor inputs the criteria and it's only a few things I go through the criteria in the video. It's BMI it's coorbidities and if you meet first of all your Medicare you're 18 or older you have the right BMI you have whatever coorbidities I think it'll be a pass through. I don't think there's somebody going, "Well, does the rain I don't >> I think it's going to be a pass through and it shouldn't take very long." No, I could be wrong. So, >> we'll just have to wait and see.
>> We'll see. But that's my understanding of the process. There will be more videos, I assure you, coming out about this as we learn more. So, stay tuned.
>> Next question. Ah, this is a good learning question.
This is from my uh picture with my standing in front of my shorts, my my old shorts. Uh this is from Shine on 6944. Question for you. You mentioned you don't track food anymore and intuitively eat with a focus on protein.
Was there a time in your 50 lb loss that you hit a plateau and eventually broke through it? Not really. I'll tell you more about that in a minute. I'm about 10 pounds away from where I want to be.
All right. I'm 5'4, 145 pounds. I'm eating as much protein as possible while balancing it with high fiber. That's good. I've been stuck at this weight since January. Interesting. Did you just accept where you are or did more weight eventually fall off? I'm at 15 milligrams. Thank you. Um, all right.
Let me let me >> dissect >> dissect this a little bit. Um I did and I think I also answered this uh directly on this question. I did not hit a plateau and I know this because I kept a spreadsheet of my weight. I've kept it for the past uh two and a halfish years.
And there was no time when my weight plateaued. However, there were weeks when my weight went up when we went on vacation or it was Christmas or it was the day after New Year like there were, you know, peaks and and valleys, so to speak, but I never kind of flatlined.
And I think the reason for that is is that I varied my calories. Not maybe intentionally, but you know, we did go on a cruise in those first three months.
It was the holidays when we started. You know, there were a lot of times where I was eating more food than I would have like on a Tuesday in May, you know what I mean? So, that just it just so happened uh to to be like that for me.
Um, and everybody's different, right? I know a lot of people plateau and what I tell them is go eat a cheeseburger, go eat a higher calorie meal, bump those calories up, get that metabolism going a little bit, and then drop it down for a while and see if that kind of um bumps you around a little bit. Uh she's 10 pounds away from where she wants to be, 5'4 at 45 lb. Um and she's been there since January and she's at 15 milligrams.
you may have you may have maxed it out, right? Um 145 pounds at 5'4 is I believe a healthy weight. Now, you guys can check me on the BMI on that, but I believe it's a healthy weight. So, um you know, what we want our goal weight to be may not be where our bodies are are going to go. So, there might be a little bit of a of a fight there. If you're at 15 milligrams, well, you've got nowhere to go. So, you're gonna keep taking your shot, right? And, you know, I think maybe over time if you really force the issue, and by force the issue, I mean eat fewer calories, get more movement in, maybe you can force it down a couple pounds. Um, you know, I don't know, talk to your doctor and see. Sometimes I heard Dr. talking about this on his podcast.
Sometimes he prescribes other med other older medications too alongside with with some medic, you know, there might be something else your doctor could suggest to help you because right now if you're at the top dose you got, you know, you not going beyond 15 and you've been at this weight since January, I'd say it's your body saying, uh, we're out of >> I'll tell you at that point. I've been on 15 for more than a year now. It's still possible to lose weight on 15.
It's harder and the close you closer you are to your goal, the less your body your body doesn't really want to lose weight. Your body is built to maintain or grow weight. It is not built to lose weight.
So what these medications are doing is Lorraine did a whole book series on the enough point is it's moving you past that point because your body basically it's telling your body it's okay. Let it go. Right? So maybe you're at a point where you need to stop. Maybe you're at I mean honestly I would just keep taking your shot doing the best you can. And it's possible a little bit comes off.
It's possible it doesn't.
>> I mean maybe you're at a point now where you want to look at maybe some body recomposition. Maybe you want to start trying to build muscle that might, you know, sometimes we get really stuck on a number on the scale and we have to think about how our clothes fit, how we look, you know, are we, you know, I don't want to be skinny and no muscle. I My goal is not to be skinny. My goal is to be strong. So, you know, I want to be able to maintain my balance, to be strong, to be able to travel and carry my suitcase and put it up above my head and do all those kinds of things I want to do. So, you know, don't get stuck on a number that, you know, may or may not be realistic of you getting there. I would still I would instead focus on uh other other parts like strength training or aerobic training or things that are good for your heart and good for your mental state and all that stuff.
>> If you don't have a smart scale like we were talking about earlier, the body pod, it's one of those things that gives you a deeper look. So instead of just that three number >> like Lan was talking about water and muscle and all those other things.
>> Yeah. Once you hit maintenance, honestly, the weight number doesn't vary much. So there's it it's not really a good indicator for the next year, two years, 5 years, 10 years, or whatever. Really, it's >> water, it's muscle, there's all these other things that if you're trying to say, hey, am I healthy? Well, you got to look at something else.
All right, let's see here. Next question. An easy one for you, Lorraine.
Avis O' Bearden says, "How tall are you?"
>> I am 5 foot five inches. Um, you're welcome. Uh, I used to be 5'5 and a half over, you know, somewhere in my 40s, I lost a half an inch. And longtime viewers will remember that my checkup, not this past March, but I guess my checkup in 202, I measured at like five, four and a quarter and I nearly had a nerves breakdown.
>> Yes, she did.
>> Uh because as a longtime member of Weight Watchers, I follow that height weight chart to for my goal weight, right? So, if I'm now shorter, I have to weigh less. And that like and you might think, "Oh, that's really dumb, you know, whatever." But it all these years of diet culture are not going to unravel in a year or two years or five years, right? So, uh, I really had to reassess like, am I at the right weight? Do I really need to focus on losing five more pounds to be at this new lower height? Um, and I really got torquked up about it. And then fast forward to the next checkup. I went in and I got my height measured. Oh, you're 5'5.
She said, "Shut the front door. Are you kidding me?" And then people told me, "Well, you can weigh you can measure different heights at different times of day." And I'm like, "What in the huh?" So, I'm 5'5. Yeah, >> she's 5'5.
Poppy Moore asks, "Can you take GLP-1 jab in your backside or your bum?" I'd like to know if injecting in this site would still be effective. I don't want to waste the medication by experimenting, so I thought I'd ask you both whether this is a viable option. So, we'll start with what the recommended ones are from Lily and Novo. recommended ones from Lily and Novo are basically a few inches outside of your your belly button in sort of a ring right here, the back of your arm, and on the top of your thigh.
There are shots like this where people do recommend your your butt basically. So, yes, you can do it. Basically, you're trying to get it into fat.
>> Certainly, you can do it. We actually were on a live last night with our friend Ally from Fit Flavor Fun and she experimented with with it a little bit.
She didn't like it, I'll tell you.
Wasn't really a function of whether it worked or not. I think she just didn't like the shot. As long as you're getting it in fat, there are people who swear by certain spots, though.
>> And you know what? Just to reiterate, we're not doctors. We're going to follow the recommendations of the drug manufacturers as to where to inject these. So, it's back of arm, stomach, or top of thigh, right? And really, my I've really only ever done the stomach. I've done the thigh a few times. I didn't like it. Uh, so I just kind of go around go around my belly button. Make sure you're injecting into fat and not loose skin. Uh, because it absorbs better if it goes into fat.
>> Next question is from Kil Goddess. Do you know about lipos suction? Would it change hormone signals in a way that would make doing it a bad idea? Thanks.
So again, not doctors >> that would make it a bad idea.
>> Right. So you actually had surgery that included some lipo, right?
>> Well, I haven't had lipo.
>> Uh well, I'm going to have to tell the whole story now.
>> Oh, imagine that.
>> But I'll try to do the abbreviated version. So, back before GLP1's, right after COVID 2021, 2022, I started thinking, you know what? I'm going to I'm just going to be 195, 200 lb forever. I'm never going to be able to get lower than this. And I've had three kids, two of which were C-sections. And I had that apron belly, right, that just kind of hang hangs hung over. And it really bothered me. And I really felt like, you know, if I could just have that part removed or, you know, a tummy tuck or something like that, I think I would feel a lot better about myself.
So, I started looking into it and the tummy tuck procedure was very expensive.
I had no insurance coverage for anything like this. And then I found another place that would just do a pinelectctomy, which is basically they just cut off that loose hanging skin, do a little lipo on the sides, not much, and then, you know, sew it back up. And that's what I did. And I went to a place called Sonabelloo. I'm not sponsored by them or anything. And they're all over the country. Um, and it was expensive. And now it wasn't overnight. their commercials would lead you to believe that, you know, one one procedure and, you know, you get a flat stomach. No, it was over the course of about six months that I had to deal with the swelling and some drainage and some everything going shifting back in. So the the interesting how this relates to this question is once I had that skin removed now I've had food noise all my life but had never named it as that at that point in 2022 because nobody was talking about it then once I had that skin removed I honestly felt like and I think I had mentioned this to you that I didn't feel so much urges to eat anymore like once those fat cells got removed or whatever there was less fat on my body like the signaling got better or you know and I've always said that I believe my hormones are disregulated I was always hungry always looking for food never full I never got a full signal and that's leptin and grein those hormones in your body regulate those right so I think I don't you I'm not a doctor and I don't know the the um scientific aspect of that, but I think it it did have something to do with it. Um, I don't think lipos suction would change it to make you hungrier, but again, I'm not a doctor.
>> So, I'm not a doctor and have never had liposuction. I do know several doctors who I actually shot this question to one of the doctors that I know and >> and they came back with a short answer, of course, saying, "We haven't seen this patient.
>> We're not their doctor."
>> Um, but gave me the general science of it. So generally what they said was remember fat is the largest endocrine or organ in your body >> and fat is not just we think of fat almost as this kind of blob of butter or crisco or something sitting there and it doesn't do anything. Well it does. It's actually sending signals and it's talking to the rest of your body all the time no matter what you weigh. That's what it's doing. It's like part of the whole communication process.
So what this doctor said was by removing some of that fat, it could temporarily change the hormonal signaling, but most doctors would not remove so much that it would be a permanent thing because honestly it would hurt you. You can't change your endocrine organ.
I forget.
>> Well, I mean I there's only so much they can take out at one time. Again, I was listening to the Navevelski brothers, the Docs Who Lift podcast, and uh one of the older brothers said, "You fat begets fat. Fat wants more fat. The fat on your body wants to remain and it wants to create more to keep it there."
>> Yep.
>> So, you know, once you get in that mode, once you hit that disease of obesity, it's chronic and progressive and it doesn't stop. Anyway, so what this doctor said was yes, there would be some temporary hormonal changes, but your body should balance out >> with the exception of they would avoid wherever you got liposuction for the shot for a while.
>> You don't have any fat there.
>> Just kind of that makes sense.
>> Just pick a different spot for a little while.
>> Yeah.
>> Is it a bad idea? No, I don't. It doesn't necessarily sound like it's a bad idea, but talk to your doctor. Make sure they understand that you're doing GLP ones, whatever that is, and have a conversation about that.
>> Here's a good one.
>> This is from, this is a long one. I'm going to put my glasses on for that.
This is from Crystal Conglaten. At the risk of sounding ignorant, I don't understand the percentage of weight loss on any particular drug. Is the percentage a total weight loss from the lowest to highest prescription of the drug, or is it how much you can lose once you reach your highest prescription? It's a great question.
I've been on MGOI for almost 6 months and lost 45 lbs. I've been on 2.4 milligrams for 5 weeks uh of that 6 months I guess. Should I expect to continue to lose or will I have to switch to a stronger drug?
>> So the percentages that you hear us and everybody else talk about come from the clinical trials, >> right? And the clinical trials percentages that are reported are always the big numbers that are a function of they took how many people were in the trial. So say you had a thousand people that trial went on for 52 weeks. How much did they how much did the average person lose? So they actually did the average math. So your average math on that right would be basically dividing those numbers and then you get to 18% or 12% or something like that. doesn't have anything to do with the doses. It's the total number of people, the amount of weight lost over the period over the time. If you wanted to dive deeper into the clinical trials, all the other data is published. So, you could go to Novoite or Lilyite or whoever and see well 14% of the them were on this dose and lost this lost this much in average.
>> Okay.
>> Well, and let me do with a numerical example.
>> Yeah. So say someone is 200 lb and zbound the average weight loss on Zepbound is 20% of your starting weight.
So 20% of 200 lb is 40 pounds. Right? So you would go from 200 to 160. 200 or to 140. Excuse me. No. Did I say that right? 40 pounds. 40 lbs is 20% of 200.
>> Yes. So you go to 160.
>> 160. So that's that's how you figure it.
So you if you want to figure your how much percent of your total body weight you have lost you take your starting weight minus your current weight divided by your current weight. Did I say that right?
>> Hard to say >> let's do it with uh let's do it with me.
>> So the number that is reported is across the total number of people in the trial.
So there may have been people who lost 60%, there may have been people who lost 2%. And it all kind of averages out to the middle and that's where you get 18 to 20%, 12 to 16, what whatever those numbers are. Asking should I expect to continue to lose or will I have to switch? We simply don't know the answer to that. That's going to be dependent on you. I've lost 38% of my body weight on through zepide zeppbound. According to the trials, that average number is 20%.
So there are plenty of people that vastly exceed it. There are plenty of people who stay at the average. There are some people who are below it.
>> I've got it now. Okay. So, uh, my starting weight was 193. My lowest weight was 138. 193 minus 138 is 55 lb.
55 lbs divided by my starting weight of 193 is 28.28 which if you convert that to a percent is 28%. So I personally lost 28% of my starting weight with Trisepide. So I beat the average and I'm just an average lady who lives in the suburbs of Charlotte, North Carolina. There's nothing special about what I did.
There's no special proced I didn't follow a special diet. I I took my shot every week pretty much except >> now go wgoi's numbers average numbers are lower but there are plenty of people that have well exceeded it.
>> Um I can tell you despite the popular wisdom around titrating slowly and all that there's really no evidence that that makes you lose more weight. You're going to lose what you're going to lose on these medications. Your body's going to do what it wants to do. Um, so keep going. Maybe you'll have to change, maybe you won't. It's hard to say, but take your shot or take your pill, whatever you're taking.
Barb Rogers says, "I hope the receptors don't eventually wear out. Is there anyone that's been on GLP1 meds long term, say 2005, where the food noise comes back?"
>> Let's let's do that in two different things. So, there haven't been GLP1s in the market since 2005.
>> Well, when did Ozimput come out? uh 2017 I think it was actually answered this question with the with the actual dates on it but basically about 20 years u it's been out so not quite >> I said it came out in 2007 >> about 20 years but you're looking at you're looking at laglutide you're looking at there's older ones >> all the older glutes >> um and those earlier ones really weren't there was not as much associated weight loss so the whole concept of food noise they they were really for diabetics and that's what they did that people lost a little bit of weight but there was no expectation around food noise >> wasn't really until we got to Ozimpic and WGOI and then Zep and Mjar that you began to get the conversation around food noise so honestly we don't know is the answer I've been on it two years she's been on it two years >> two and a half yeah on three in September >> I don't really have food noise every once in a while it creeps in at the end of the week but >> I think over Me personally, so now we've been on this for medication for two and a half years. I was on, if you followed along, you know that I was on a 7.5 milligram dose for about a first year of my maintenance was 7.5. Once I I came down from uh the 10 or the 12.5. I came down in dose because I thought you were supposed to. I wanted to see if I could maintain with a lower maybe for cost reasons or for whatever. Came down in dose. uh was on 7.5 for a long time and about two months ago I just started feeling really snacky and maybe a little food noise especially at the end of the week and um you know I just I kind of felt like I needed a little bit more help from the medication. And so I went up to 10 milligrams and it's been it's been a little bit better. Now at the toward the end of the week, like today is our shot day. Today's Friday, it's our shot day. I was I've been a little snacky. Like I've like it's it it's it's my shot day, right? This medication has a fiveday halflife. So days one through three, I can you can put anything in front of me and I'm going to be like, I might have a bite and that's fine. But days five, six, seven, I might be like, "Yeah, let's try that out a little bit more.
Let's take a extra few bites." So, I think maybe I feel like personally over time, over the course of another three years, will this still work? Will the trapatide still have the same effect on my body?
I don't know. But three years from now there's going to be 20 more medications that hit the market in GLP1s. There's going to be all kinds and different pathways like Kagraimma Red like I we don't even know. There's so many in development that there's going to be all these different ones. So does your body adjust to it over time?
Probably.
But I'm not worried about it because there's other things on the horizon. And just functionally the idea of receptors wearing out, it's not really the way it works. And I'll refer you to that. We did a interview when we were in Atlanta at Obesity Week with our friend, the fabulous molecular biologist condandy Carmarmac, who printed 3D models of of the cells of >> of your the whole of all of it. And basically what he does is he's got these 3D models and they're like 10,000 times blown up or something, right? So they're like this big versus, you know, I can't even molecules. Um, and he showed you that essentially the way it works is more like a lock and key and the tzepide or the semiglutide kind of fits into a spot and starts and stops things. It's a fascinating video. He's he has multiple PhDs and things. take a look at it because he talks about that extensively and it's not really a question of wearing out. So when it generally the belief is similar to what Lorraine just said about how can your body become accustomed to it over time. Yes, we know in the titration cycle we begin to become accustomed to it and you do it but with new drugs it'll change but wear out's not quite the idea that it is. So, next question for Lorraine.
>> This is from Lisa Marie 1937. Hi, Lorraine. Smiley face. A couple weeks ago, on one of your lives, you mentioned a product that could possibly help hair loss. I believe it started with the letter N. Do you remember what you said, what the product name is? Thank you for your channel and all the information you give. Um, yeah, it's on our Amazon store. If you go to the downsize.org or and click on the store tab. You can pull up all my GLP1 favorites and recommendations. And this is the product she's looking for is is a vitamin supplement called Neutrifull. Now, I haven't personally taken this one. My hairdresser did recommend it to me back a couple of years ago when I was in the height of my weight loss about four months in. I noticed my hair was getting a little thinner and I asked, you know, my hairdresser and she said, "Yeah, some people have success with this." So, um, you can definitely check that out. Mochi Health also has some prescription strength hair growth medications like minoxidil and things like that. So, if you're a Mochi member, you can get other prescription medications from your mochi doctor. But if you are just looking for like a vitamin that might help, it's a newer fall and that's on our Amazon store.
>> Right. Next question is from Elaine Edwards who says, "I have a question theory. If stronger drugs are now being tested, would it not be possible to have a higher dose of tepatide than 15 milligs? For those on maintenance or struggling at 15 milligrams, I wonder if a slightly higher dose might meet those needs. I wonder why 15 milligrams was the magic stop dosage during the studies. Food for thought. Don't you agree? Um I'm not sure what I'm supposed to agree with, but I can tell you what I know.
>> Higher dosage.
>> So So there are higher doses currently being tested of Mangaro for diabetics. I don't think there's any any being tested for Zeppbound, but there's I think a 20 and a 25 milligram dose of Muro being tested. So I think it it that's going to come across the board. Why they actually chose to stop the 15 milligrams for the I don't at some point they have to just pick a place to stop. I don't I don't think there's any big wisdom around that.
>> I can tell you I've actually taken a 16.6 six milligram dose that came from >> Mochi's top dose of 16.6.
>> Some of theirarmacies, not all theiries do that, but and I actually thought it did well for me. So that little bit of extra kind of got me to my goal that the 15 wasn't quite doing for me.
>> This is coming in a FedEx box today.
>> I like the I like the 166. Um, so I do think eventually you'll see higher doses from Lily of Zepbound and for them it's really a portfolio play of how do we have a a portfolio of products that can deliver on every all the metabolic needs whether it be obesity or diabetes or sleep apnnea or whatever. So with foundo zepbound and reatride coming soon it gives them the full span of products. So yeah, I think you will see higher doses recommended at some point when that happens. Your guess is as good as mine.
All right, so final question from JK Susan who says, "Hey, I've seen you guys have been traveling a whole lot. How are you taking your medication with you?"
>> Oh, how do we travel with it?
>> Well, this is our travel case. So, yes, we take our shots with us. This one is on All of these that I'm about to show you are on our Amazon store. So, you can go to the downsize.org, click on the Amazon tab, and go right to these. This particular one comes with the reusable, refreezable cold packs, and it has a little pocket inside. I'll tell you about this in a minute. Uh, a little pouch where it has these little handy dandy straps. You can put your pens in there. You can put your uh needles in there. Uh I like to put the vials in this little zippered pocket. It keeps that really handy. And >> and it's blue because I like blue and she makes me carry it usually.
>> Yeah. This little number is a needle snipper. So you can take your used syringe, stick the needle into this hole, and you click it and it snips the needle off and keeps them in there. You kind of hear them in there. Um, and then this is you can also keep this in there.
We kind of like to sniff them off if we're in a place where um we don't necessarily have a sharps container or we need to just whatever. It's just very handy to have. Okay. Um, that's contestant number one. And this is kind of like our favorite that we take with us and we will be taking this on the cruise.
We recently ordered some different ones because that one's kind of bulky and are there other newer better options? And so we found this one which is much smaller. So here's my phone. I'll compare. You can compare it to my phone, right? So it's it's it's like a pencil case really. Uh, it has the the reusable cold packs. It has the handy dandy elastic. It has the little pouches so you could put your needles in here, your vial in here. Zip it up.
>> So, I mean, what's I like this case a lot cuz it stays cold for a long time.
It's kind of a pain. I carry this in my carry-on backpack kind of thing and it fills up a lot. I like this size better, >> but honestly, you see the difference in the size of the cold packs.
>> The size of the cold pack. So, if I was going for very long, I would keep this one.
>> Yeah. If you're going on a 9-h hour flight, I'd do the bigger one. If you're flying to Florida and it's a 2-hour flight, you know, it's and and also let us mention that um you want to keep the medication refrigerated. Uh once it comes to room temperature, uh it's good for 28 days, right? And you need to use it. Once it comes to room temperature, you don't have to go back in the refrigerator. You don't want it to get above 80 degrees because that's not good for it. So, as long as you uh follow those kind of rules, you should be fine to travel.
>> So, we also got contestant number three.
Um, so our daughters travel, too, so we got some of these for them. This one is actually a zip bound shaped pen case. I >> mean, this put your little zip bound pen in there, >> which is kind of clever.
>> This case is kind of heavy, but it's very nice. Yeah.
>> Yes. It's a little bit bigger than this guy. If you can tell, but um it's a little bit it's a little bit bigger.
>> And then we got this softer case. Kind of >> I thought this was really kind of pretty >> cuz you thought it was cute. And it has little gold handles and you know, all kinds of fun stuff.
>> Mhm.
>> And >> it looks more like a makeup case.
>> Yeah. It zips open. Very similar thing.
It would be just fine. Uh now I can tell you if you're on the cruise with us, whichever ones my uh child don't want, we're going to use as as door prizes, too. So >> yeah. So this, you know, same thing you put the ice packs in here. And this I I mean, if you're traveling with uh maybe some people and maybe you don't want to share with them that you are taking this medication, this looks like a makeup bag to me. This this could go anywhere, right? You want to keep your medication in your check luggage. This even has a little clip. You could like clip it onto your backpack. Nobody's going to be any the wiser, right?
>> And then finally, we've shown this one before as well, too. This is a quick pen case. So, the quick pins once they come out of the refrigerator and you've used them once, don't have to be refrigerated. They can be at room temperature for 28 days. So, this case is just to protect the pen. There's no insulation in it at all. And the pen actually goes in this slot. And this slides in here. And then there's a side here. You can put each of your needles >> in here.
>> This I traveled with >> uh to Europe actually with one of these.
Super easy. Small in my backpack. No big deal. Yeah.
>> I liked this a lot. I would have probably gotten the black one just because I prefer more neutral. But >> I did. Yep. I But I was ordering it for the ladies in my life and there was multiples. So there's a pink one.
ladies in your life, the ladies like pink.
>> There's also a pink one. It was supposed to be a pink and a and a lavender one.
>> Oh, and we they didn't they shipped >> Yeah. So, um, one of our daughters is trying out the the quick pen just for ease of use with travel and, you know, she she's at school and she she doesn't share with her roommates her, you know, private health information and that's fine. So, she really wants something that's going to be compact. She is also not comfortable giving herself a needle and syringe type injection. Um, so that's why when she's at school, she has to for her to for us to enable her to stay on the medication, she uh is using the quick pen for that. And that's fine.
>> That being said, she's been very successful with it. So, >> yes, she's lost well, should we say?
>> Sure. 140 pounds. She lost 140 pounds.
Um, so yeah, what whatever whatever it takes to keep her uh on the >> do anything to take care of my babies.
>> Yeah, for sure.
>> All right.
>> All right.
>> So, that's our questions for this week.
If you'd like to submit a question for the weekly weighin, you can leave it underneath this video. Use a question mark and we'll sort it. Maybe we'll answer your question next week. We'll be in a different location next week. I think we'll actually be in Miami to do this >> because we'll be leaving for the Downsized at Sea cruise.
>> Stay tuned. We'll be publishing some meetups around the country for the rest of the year. So stay tuned. That's coming soon, probably after we get back from the cruise.
>> Is there anything else going on? OAC convention.
>> Yeah, in July we'll be at the OAC Your Weight Matters convention. I believe the dates are July 23rd through the 25th in Orlando, Florida at the Renaissance SeaWorld Hotel. Uh you can use our code, we'll put it in the description and save $20 off your registration. So Christopher and I will be there recording videos. We have like a a video >> podcast.
We'll be talking and recording videos with the doctors, with the patients, with the people at the OAC. Hope you can come join us for that. And there will be a corresponding meetup that has no cost associated with it. So you'll be able to come if you're in that area and say hello >> and just say hello.
>> Yep. All right. That's it for us this week, I think. Have you liked and subscribed?
>> Have you liked this video? Have you shared it with a friend? Sharing with a friend really helps the algorithm uh reach more people who are looking for information on a GLP1. And what we found is people are looking for information on GLP1's, how to get started, how to do it, what do I what what do I got to do, right? So, we have some other videos specifically. I made one, it's a shorter one about, you know, how to get started with a GLP1. So, if you have a friend who maybe is asking you some questions about how you lost your weight, you can share that video with them as well.
>> All right. Well, thank you very much for joining us this week. My name is Christopher Durham.
>> I'm Lorraine Durham. And we are the downsized.
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