The Mechanism Behind Chemo-Induced Neuropathy #chemotherapy #cancertreatment #education

Added: 2026-05-26

[00:00:00]Platinum drugs and acute neuropathy.

[00:00:03]Let's start there. Again, this is things like carboplatin, cisplatin, and oxaliplatin.

[00:00:09]The ox in FOLFOX. Acute neuropathy here usually shows up both often, over 90% of the time, and fast.

[00:00:16]Often right after or even during the infusion. And it's driven by two main issues. A buildup of calcium inside the nerve cells because of the actual drugs.

[00:00:26]Oxaliplatin binds calcium.

[00:00:28]And sodium channel dysfunction on the nerve surfaces. Translation, your nerves get electrically cranky. And that crankiness can last for an entire week before resolving itself.