To measure the heart's electrical activity, the negative electrode must be placed on the endocardial side (inner wall) and the positive electrode on the epicardial side (outer wall), because the electrical impulse propagates from inside to outside the heart wall, meaning depolarization direction flows from the negative toward the positive electrode.
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Added:If we want to measure the electrical activity of the heart, we must place the negative electrode on the endocardial side and the positive electrode on the epicardial side because the electrical impulse in the heart propagates from the inside of the wall to the outside of the wall. Thus, the direction of the depolarization will be from the negative electrode toward the positive electrode of the electrocardiograph or ECG.
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