Sobetirome GC1 is a synthetic thyroid receptor agonist that primarily accumulates in the liver (30-fold lower heart concentrations compared to T3), inducing adaptive thermogenesis in white adipose tissue and lowering LDL cholesterol by up to 41% without significant effects on thyroid axis or heart rate, though its clinical development was halted due to funding concerns stemming from Eprotirome's liver toxicity and cartilage effects observed in phase three trials.
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Increase White Adipose Tissue Thermogenesis And Lower Cholesterol With This Compound
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