Medicina 1046 Máster Anatomía Patológica Patólogos 00136290 M7 T4 EN Horizontal

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[00:00:01][music] >> Malignant neoplasms of the seminal vesicles are extremely rare entities [music] within the pathology of the genitourinary tract. However, their recognition is crucial due to their aggressive behavior and the [music] diagnostic challenges they present.

[00:00:19]In this context, primary adenocarcinoma [music] is the most frequently described subtype, characterized by non-specific clinical [music] presentation, hematuria, hemospermia, dysuria, or a palpable superprostatic mass, and by a typically delayed diagnosis, [music] which leads to a poor prognosis.

[00:00:40]Histologically, it can exhibit papillary or mucinous patterns [music] with mucin production and marked atypia, making it essential to rule out secondary infiltration [music] from the prostate, rectum, or bladder.

[00:00:54]In immunohistochemical [music] terms, these tumors usually express CK7 and CA125, with negativity for PSA and PAP, which allows them to be differentiated from prostatic [music] adenocarcinoma.

[00:01:10]Furthermore, the comparative study of markers such as CK20, CEA, and MUC6 is [music] key to establishing the differential diagnosis from bladder, colorectal, or urachal neoplasms.

[00:01:26]In addition to adenocarcinoma, exceptional variants have been described [music] such as primary squamous cell carcinoma, sometimes associated with chronic [music] inflammation or Zinner syndrome, neuroendocrine tumors with a poor prognosis, and mullerian adenosarcoma-like lesions.

[00:01:46]Consequently, the approach requires clinical, radiological, and histopathological correlation, with radical surgery [music] being the main therapeutic strategy, while the response to chemotherapy or hormone [music] therapy is usually limited.

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