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The Nuremberg Code, established in 1947 after the Nuremberg doctor's trial, created fundamental ethical principles for medical research including informed consent, the right to withdraw from studies, and prohibition of experiments serving no legitimate purpose; these principles were developed in direct response to the systematic atrocities committed by doctors at Hadamar killing center, where 200,000-300,000 people were killed by medical professionals who simply marked boxes on forms, serving as a permanent reminder of what medicine becomes when it forgets its purpose.

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