AUTOCOID MOST IMPORTANT MCQ BY PHARMA SAPIENCE GPAT/NIPER/DI/GOVERNMENT PHARMACIST

追加: 2026-05-14

[00:00:00]Hello everyone, welcome to Pharma CPN. Today we will discuss 25 Most Important MCQs from the topic of Autocid Pharmacology.

[00:00:07]Let's discuss one by one. So the first question is which one of the following drugs is used in the management of open ductus arteriosus in premature infants by promoting ductus close. Option A: Alprostadil, Option B: Indomethacin, Option C: Dobitamin and Option D: Adrenaline.

[00:00:24]If we are talking about open ductus arteriosus or patent ductus arteriosus. So in this condition or we can say that this condition is seen due to the synthesis of prostaglandin E2. If we inhibit its synthesis then in this condition we can close this patent or open ductus arteriosus.

[00:00:40]So if we want to stop the synthesis of prostaglandin E2, then of course we will have to stop the COX pathway. So for this, the best drug or Cox inhibitor is the only drug we can see. That is the endomethacin. So option B will be the correct one. Talking about indomethacin, it is a non-selective COX inhibitor.

[00:00:56]If we talk about Alprostadil, it is a Progradin analogue. So this option will not be ours. Do vitamin is a dopamine derivative. It is a beta one selective beta one receptor selective. So Domin is also not our correct answer. Adrenaline is a sympathomimetic neurotransmitter. So our option D will also become incorrect. So we are left with only one option. That is the endomethacin. So, one of the most common prostaglandin analogues is alprostadil, which maintains the patency of the ductus and atrium, keeping them open. But it can't close it. If we want to close it, we will have to give Cox's inbiter. Like Indomethacin dobitamine is a beta one agonist which is inotrope.

[00:01:30]If we talk about adrenaline, it is a neurotransmitter and which is used for the anaphylaxis treatment and cardiac but not for the patent artery ducts. The only option we have is Indomethacin. So the next question is which one of the following drugs is used in the medical termination of the frequency? It is NIPER JE 2023 MCQs.

[00:01:49]Option A. Mizorapin, Option B. Method, Option C. Mifeprin and Option D. Dinoprin. If we are talking about mesoprolol it is a PGE2 analog Methot if we are talking about it is a dihydrofolate reductase inhibitor if we are talking about mesoprolol then yes it is a progesterone receptor agonist if we are talking about Dinopril then yes it is also the same PGE2 analog we are getting one drug that is a mifeprostone which is a progesterone agonist so yes it acts or we can say it is useful for the termination of the pregnancy so option C will be the correct explanation if we are talking about mesoprolol it is a progesterone receptor agonist which blocks the progesterone action and detachment which is responsible for the detachment of the trophoblast it is useful for the medical termination of early pregnancy used mainly following by the misoprolol Mezopral and Dinopr both are the PG E2 analogs which cause the uterine contractions. If we talk about method, it is an antifo drug which is used in ectopic pregnancy not for the term. So if we are talking about the next question.

[00:02:48]A child has a proximal renal tubular defect with hypokalemia, metabolic alkalosis, and normal blood pressure, which is one of the four defects most likely responsible for this condition.

[00:02:59]Option A: Increased renin secretion, Option B: Increased S activity, Option C: Defective prostaglandin synthesis, and Option D: Increased aldosterone secretion. So here the condition is given that a child has a proximal renal tubular defect with hypokalemia, metabolic alkalosis and normal blood pressure, one of which is defective is most likely responsible for this condition and that condition is known as the Bartter syndrome. If we talk about this syndrome, whenever there is excess renin secretion in the body, then this condition is called Bartter syndrome. If we talk about its treatment, here the treatment indomethacin will be the drug of choice for the Bartter syndrome. Yes, option A will be the correct increase in renin secretion.

[00:03:38]Next question is if we talk again the same question from the Bartter syndrome, which one of the following bases describe the mechanism underlying Bartter syndrome. Option A: Excess aldestron secretion leading to the salt wasting.

[00:03:48]Option B: Defective prostaglandin synthesis causing increase in the Sodium chloride reabsorption in tubular thick ascending loop Option C decreases ADS secretion causing polyuria and dehydration and Option D increases ANP secretion causing nephrosis and hypokalemia. So if we are talking about the pathophysiology of Butter syndrome, then in this condition, we will see maximum reabsorption of sodium chloride in the thick ascending loop of the tubule.

[00:04:20]So our option A will be incorrect.

[00:04:24]Option B: Defective protagan synthesis causing increased sodium chloride reabsorption in the solution. So yes option B will be the correct one.

[00:04:32]If we talk about the next question explanation, then Barr syndrome is due to the defect in the protein synthesis and loss of inhibitory effect of sodium chloride reabsorption in the thick ascending loop of the inlay due to which the reabsorption of sodium chloride will increase.

[00:04:45]So yes option B will be the correct one. Next question is from the AIIMS and RRB.

[00:04:50]This question has been asked in both the exams.

[00:04:51]Which of the following drug is used in the treatment of myocardial infarction as a thrombolytic agent? Option A Alteplase Option B Aspirin Option C Aspirin Option D Clopidogrel If we are talking about thrombolytic agents then Streptomycin, Alteplase, all these drugs are seen as thrombolytic agents. So option A will be the correct one. B. If we are talking about heparin then it is an indirect thrombin inhibitor.

[00:05:21]If we talk about aspirin, it is a thromboxane inhibitor. And if we talk about Clopidogrel, it is a P2 white receptor blocker.

[00:05:29]So we get only one option. That is the ultimate place.

[00:05:33]Talking about its explanation, ulteplase is a tissue plasmin activator which converts the plasminogen to the plasmin which dissolves the fibrin coil and which is used in the myocardial infection. Heparin We All Know It Is an Indirect Thrombolysis Inhibitor?

[00:05:45]If we talk about aspirin, it is the thromboxane inhibitor and if we talk about clopidreal, it is the P2 white receptor inhibitor.

[00:05:52]Which of the following drug is a selective thromboxane synthase inhibitor used as an antiplatelet agent?

[00:05:58]Option A Silastazole Option B Ozagre Option C Abscib Option D Option D Epoprostenol If we talk about silistazole, then it is a phosphodiesterase 3 inhibitor. If we talk about ABC map, then it is a glycoprotein 2B and 3A inhibitor. Whereas if we talk about epoprostenol, then it is a prostaglandin I2 analog, that is, it is a prostacyclic analog. So we have only one option, that is a Ojha grill. Ojha Gril which is a selective inhibitor of the thromboxane synthase.

[00:06:33]So option B will be the correct one. Oja Grail which is a selective inhibitor of thromboxane synthase which decreases the thromboxane level and inhibits platelet reaggregation. Next question is which one of the following drug is used in the treatment of rheumatoid arthritis by inhibiting the leukotriene synthesis.

[00:06:50]Option A is Methodeg Option B is Zeloton Option C is Sulfa Salazine and Option D is Hydroxychloroquine Hydroxychloroquine is a derivative of chloroquine.

[00:07:00]If we talk about sulfa salazine, then it is a folate synthase inhibitor. If we talk about methotrexate, then it is a dihydrofolate reductase inhibitor. So only one option is available to us that is Zeloton which is a LOX inhibitor which inhibits the synthesis of the leukotriene. So option B will be the correct option.

[00:07:17]Other option is available to us that is Zeloton which is a disease modifying anti-inflammatory drug for arthritis which does not have any effect on the leukotriene synthesis. Hydroxychloroquine is an antimalarial with immune modulatory action. So only one option is available to us that is Zeloton which is a five LOX inhibitor which inhibits the leukotriene synthesis.

[00:07:37]Next question is which of the following drug is a Prostacyclin Analog Option A Prostacyclin Analog to Treat Pulmonary Arterial Hypertension Option B Iloprost Option C Treprostinil and Option D All of the above So we all No Iloprostenol is a PGI2 and prostacyclic analog as well as Iloprost and Treprostinil both are also considered as analogs of prostaglandin I2 So yes all options are correct So option D will be the correct Prostacyclin is a potent vasolator and it inhibits the platelet aggregation If we talk about its analogs then Iloprostenol Iloprost and Treprostinil these all are the prostacyclic analogs. Next question is: One of the following drug is used as a leukine receptor antagonist in the treatment of allergic rhinitis. Option A: Zap Lukast, Option B: Cetirizine, Option C: Montelukast, and Option D: Prednisolone.

[00:08:36]So if here we are talking about leukotriene receptor antagonist. So option A yes zap licst is also licotine receptor antagonist. Cetirizine is our HH1 agonist Montek is also the glucocorticoid receptor agonist and option D Prednisone which is a which is a glucocorticoid here we are seeing two options Zypar Lukast and Montekast both are glucocorticoid receptor antagonists but if we are talking specifically in the condition of allergic renitis so yes there we will go with the Mettelkast so our correct answer will be the Montekst next question is one of the following drug is used to inhibit the thromboxane synthesis as an anti platelet agent option A Aspirin option B Indomethacin option C Diclofenac and option D Paracetamol so we all know about the thromboxane synthesis inhibitor that is the aspirin which is salicylic acid derivative talking about indomethacin it is a non selective COX inhibitor Diclofenac is also one of the non selective COX inhibitors whereas paracetamol is also the other which has analgesic antipyretic but not anti inflammatory action so if we talk about thromboxane synthesis then yes there is only one option that is aspirin so that is the explanation thromboxane promotes platelet aggregation and vasoconstriction so aspirin it irreversibly inhibits the COX in platelet and decreases the thromboxane synthesis next question which one of the following drug is used as a selective COX inhibitor in the treatment of bronchial asthma.

[00:10:17]What are the five lock inhibitors that we use to treat asthma? Option A Zeltan, Option B Montonakst, Option C Endomethacin and Option D Dexanthosum. So yes there is only one option is there Zelton which is a five locks inbetween. If we talk about Mantakast, it is a leukotriene receptor inhibitor. Talking about indomethacin, it is a cox inhibitor. If we are talking about Texamethosan.

[00:10:41]So it is a glucocorticoid.

[00:10:47]Filo catalyzes the conversion of arachidonic acid into lactose.

[00:10:52]Zelton is a file inbiter? Yes, speaking of Montont, is it a leukotriene receptor antagonist? Indomethacin is a COX inhibitor and dexamethasine is a glucoid.

[00:11:01]Next question. Which one of the following drugs is used to prevent labor by relaxing the uterus through the stimulation of the beta 2 receptor. What kind of drug is this?

[00:11:09]Which prevent labor relaxation in the uterus through the stimulation of the beta 2 receptor. So it is simply talking about the tocolytic agent.

[00:11:20]Option A Hiritotan, Option B Methyl Ergometrine, Option C Carbopyr and Option D Mezopyr.

[00:11:27]So beta-2 receptor agonist which is useful as a tocolytic agent. So here we have to remember a simple trick. Ser s i r t. S will be our subtest.

[00:11:37]I stands for Isoxapan R stands for Ritodrin and T stands for Terbutaline So yes option A will be the correct one that is Ritodrin beta to aces like Ritodrin Isoxapan Terbutaline sobat means they all increase the cyclic MP in the uterine smooth muscle and which cause the relaxation which is used as a tocolytic to prevent the preterm labor If we talk about methyl ergometrine it is an alkolytic which causes the uterine contractions Carboplast is a prostaglandin F2 analog which causes uterine contractions If we are talking about Mezobrostol.

[00:12:09]It is a PG even analog and is used for the medical termination and induction of labor.

[00:12:15]Next question: Which one of the following drugs is a thromboxane synthase inhibitor used as an antiplatelet agent. What drug acts as a thromboxane synthase inhibitor? Option A tick griller.

[00:12:25]Option B. Aspirin, Option C. Clopidogrel and Option D. Diperidol.

[00:12:30]Talking about Ticargiller and Cropidogrel, these both are the P to white receptor inhibitors.

[00:12:35]And Dapperdmal if we're talking. So yes it is a phosphodiester inhibitor. The only drug we have left is aspirin, which acts as our thrombocytopenia synthesizer.

[00:12:45]So option B will be the correct one.

[00:12:51]Next question: Which of the following drug is used in the treatment of bronchial asthma by inhibiting leukotriene receptor? Option at Option B Mulcast Option C Indomesine and Option D Sal.

[00:13:07]If we talk about silametal then it is a beta2 receptor agonist it is the long acting beta2 receptor agonist indomethacin is a cox inhibitor non selective cox inhibitor If we talk about zoletan it is a loox inhibitor and montelukast yes it is a lutrine receptor agonist so option B will be the correct answer leukotriene which is used in asthma apart from this montelukast is a loox inhibitor next question is which one of the following drug is used in asthma as a selective thromboxane receptor antagonist as an anti platelet agent so we have already discussed such question if we talk about aspin then yes it is a thromboxane inhibitor clopidrem prasugrel ticagrelor all are the p20 receptor inhibitors on ADP.

[00:14:07]Next question is: One of the following drugs is used in the treatment of migraine by acting as a serotonin 5HT1β receptor agonist. Option A: Sumatriptan, Option B: Mechlorpropamide, Option C: Propranolol, and Option D: Ergotamine. We also use this in the condition of migraine.

[00:14:25]Propranolol it is used and we can say the drug of choice for the prophylaxis of migraine Metochlorpropamide which is act as an anti emetic drug Sumatriptan yes this is our drug which acts as a selective receptor agonist of 5HT1β. The most appropriate answer would be the one that is suma triptan 5H1β D receptor agonist cause cranial vasoconstriction and inbit the neurogenic inflammation. So the suma triptan is a selective 5H1β agonist. In the condition of migraine, we see dilation of our cranial blood vessels.

[00:15:04]So yes for the treatment we have there constriction will be the must. So triptans will be the drug of choice for such conditions. Mediclophamide is an antiemetic and D2 receptor antagonist Propernal is a beta blocker Protamine is a non-selective it is also used but not a selective 5H1β receptor agonist Next question is which one of the following drug is used in the treatment of pulmonary arterial hypertension by acting as a prostacyclin analogue Option A Epoprostenol Option B Ibrosentone Option C Sildenafil and Option D Ambrisentane If we are talking about Ambrisent. So it is an endothelin receptor agonist.

[00:15:46]Endothelin receptor agonist. Sildenafil we all know it is a phosphodiesterase five inhibitor.

[00:15:54]If we talk about bosentan, it is an endothelin receptor agonist. Same like the Ambrisent. We have only one drug left which we have already discussed.

[00:16:02]That is an epoprostenol. It is the prostacyclan and we can see PGI2 analog. So option A will be the correct one.

[00:16:10]Prostacyclin is a potent vasolator and inhibits the platelet Prostanol is a prostacyclin analog.

[00:16:16]Prostanol and ambrisant are both endothelin receptor agonists.

[00:16:25]Talking about sildenafil, yes it is used in erectile dysfunction which acts as a phospholipid inhibitor. Next question which of the following drug is used as a phospholipid inhibitor for the treatment of chronic urticaria is asked to us here. Option A Montlicast Option B Zeltan Option C Lora Tidan and Option D Fenisan.

[00:16:47]We discussed this before also. Zeltan is a five locus inhibitor. Montelukast is a leukocyte receptor agonist.

[00:16:56]If we are talking about loratidine which is H2 receptor agonist and if we are talking about prednisone. So yes it is an immuno suppressant glucoid. So option B will be the correct one.

[00:17:08]Next question is which one of the following is used in the treatment of bronchial asthma by inhibiting the leuko synthesis Option A Cromolean sodium Option B Chapkast Option C Theophylline and Option D Hydrocortisone Option A Cromolean sodium ki agar aapnea hai, then it will be seen as a mast cell stabilizer Japar Chapkast is a leukotriene receptor agonist Theophylline is a phosphodiesterase 3 inhibitor Hydrocortisone ki agar aapnea hai.

[00:17:40]So yes it is not a glucoid lox inhibitor but yes if we are talking about Zhap Lukast then it will be seen as our leukotriene receptor antagonist.

[00:17:49]So as per the option, we will go with option B. That is the Jhapar Lucast.

[00:17:56]Next question is with the following drug is used as selective prosta glandan I2 i.e. prostacyclin analog alprostadil mesoprostol carboprost dinoprostone if we are talking about alprostadil it is analog of our prostaglandin E1 then this will not be our option. If we're talking about CarboPro, then this would be our Prostaglandin F2 Alpha analog.

[00:18:24]If we are talking about Dinopr, then this will be our prostaglandin E2 analog. Whereas if we are talking about Mezoprale. So it is a prostaglandin E1 analog we will see.

[00:18:38]But if we are talking about options, then here we will not find any analogue of Prostaglandin I2 i.e. Prostacycling.

[00:18:44]If here in the options epo prestinol or ilopast or tre prostinal all these drugs are present then yes there is a little error in the options here but yes they are all our prostacyclin analogue and prostadil is a prostaglandin E1 Mesoprostal is also our prosta glandin E1 analogue Carbopra PGF2 alpha and Dinopra also our PG2 analogue Next question is one of the following drugs is used to prevent the gastric mucosal injury by acting as a prostaglandin analogue action it is a nipper G 2022 question option A Mesopral option B Omezole option C Renitin and option D Sucralfate which drug will prevent mucosal injury by acting as a prostaglandin analogue action only one option we are seeing is the misopral that is PG E2 analogue If we talk about omeprozol then yes it is a proton permeate Renidine is a H2 Receptor agonist and sucralfate is a protective agent which form a layer on the ulcer. So the only drug we are seeing is Misopral. It will work as a prostaglandin analog and there we will see protective action.

[00:20:03]Next question is which one of the following drug is used as a thromboxane synthesis inhibitor for the prevention of myocardial infection.

[00:20:11]Option A: Aspirin. Option B: Clopid. Option C: Ticagrelor and Option D: Abixim. Ok?

[00:20:16]We will not discuss this much.

[00:20:18]We have solved the same questions before also.

[00:20:19]That is aspirin is our thromboxane synthesis inhibitor.

[00:20:24]Next question is which of the following drug is used in profile of migraine by agonizing five HT to B C receptors.

[00:20:32]Option A Pizotifen, Option B Propranolol, Option C Reza Triptan, Option D Suma Triptan. Option C & D Both of these act as agonists of our 5HT1B or D receptors.

[00:20:45]So both of these will not be our correct answers.

[00:20:47]Propranolose is a beta blocker, so this will also not be our correct answer.

[00:20:51]Pizotifen if we're talking about or ketotifen if we're talking about, which acts as a 5HT2B receptor agonist. So yes, here option A will be correct for us. That is the Pizotifen Pizotifen 5HT2B receptor antagonist which reduces the migraine frequency which is also used in the treatment of hypertension Talking about Propanol, this is our beta blocker. Reese trypan and and and and and and and and and and and and suma trypan these both are the five H T one B D receptor and agonish which we use in the treatment of migraine.

[00:21:25]Next question: Which of the following drugs is used to prevent gout that causes uric acid synthesis? Option A. Allopurinol, Option B.

[00:21:34]Febuxistate, Option C. Probene acid and Option D. Colchicine.

[00:21:39]If we talk about colchicine, then yes it is a chemosis inhibitor.

[00:21:47]Colchicine will work to stop the movement of any inflammatory mediators.

[00:21:51]This is not related to uric acid synthesis.

[00:21:53]Probene acid: This will increase the excretion of uric acid.

[00:21:57]Alloparinol is a uric acid synthase inhibitor. Along with this, Febuxist is also our uric acid synthesis inhibitor.

[00:22:04]If we are comparing both of them, then we will give most preference to Allopinol. So option A will be the correct answer.

[00:22:10]Allopinol is a xanthine oxidase inhibitor which decreases the uric acid synthesis.

[00:22:14]Febuoxide also inhibits the xanthine oxidation. Probenecid increases the excretion of uric acid.

[00:22:18]Colchicine is involved in the microtubule polymerization and also in the chemotaxis process.

[00:22:28]Here the correct answer is our Alloparinol.

[00:22:30]We will get to see this. Next there is a case based study which is asked in the NIPER JEE 2020. A 22 year old male presents with a severe anaphylactic reaction after an injection of penicillin? Which of the following mediators is primary responsible for the immediate vasodilation and increased vascular permeability and bronchoconstriction observed in this reaction Option A Prostaglandin E2 Option B Bledognin Option C Histamine and Option D Leukotriene B4 So here is a case of a 22 year old male who has a condition of severe anaphylactic reaction along with immediate vasodilation and increased vascular permeability so with which autocyte will we see all this?

[00:23:13]Prostaglandin E2, bradykinin, leukotriene B4, if we are talking about histamine, then it remains our responsibility. Vasodilation increases permeability also and bronchoconstriction.

[00:23:26]We can see all these characters inside the amine autocid.

[00:23:28]That is the histamine. Yes the correct option would be the C that is the histamine. Anaphylaxis is an IgE mediated type 1 hypersensitive reaction.

[00:23:37]We also have to keep this point in mind. Mart cell degranulation which releases the preform newly synthesized mediator. Histamine immediate release which causes vasodilation, vasocompatibility and bronchoconstriction and also the priorities?

[00:23:49]So the next and last question of this topic is a patient taking low dose aspirin for the cardiovascular profile who develops an acute bronchosm. Which of the following is the most likely mechanism? Option: Aspirin increases prostacyclin synthesis. Aspirin inhibits COX one which leads to decrease in the prostacyclin and increases leukotriene synthesis in the bronchi.

[00:24:11]Option C: Aspirin blocks histamine receptor and Option D: Aspirin stimulates LOX pathway.

[00:24:19]Aspirin increases prostacyclin synthesis. No, this will not be our correct answer.

[00:24:22]Yes, if aspirin is inhibiting COX then we will see decrease in prostacyclin synthesis and not increase. So, option A is incorrect.

[00:24:29]Aspirin blocks histamine receptor.

[00:24:31]Aspirin has no action on histamine receptor.

[00:24:33]Aspirin does not stimulate the LOX activity. It inhibits the COX pathway and does not stimulate the LOX pathway. So by inhibiting the Cox1 enzyme, we will see a decrease in the synthesis of PGI2.

[00:24:45]And it will cause the unexpected licorice synthesis which will lead to the Broncos. So yes, B is telling us a correct pathway or correct framework. From the bronchospasm due to the aspirin treatment. So these are some of the most recent 25 MCQs from the topic AutoKid.

[00:25:02]I Hope This All 25 MCQs