Mass spectrometer and absorbance (UV-Vis) detectors are best suited for HPLC because they are liquid-phase compatible and provide high sensitivity and reliable compound identification, while thermal conductivity and flame ionization detectors are primarily designed for gas chromatography applications.
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UGC NET JRF Environmental Sciences December 2025 | Q4 Paper2 | #ugcnet #netjrf #ugcnetjrf #shortsAdded:
Hello students, welcome to UGC NetJRF Environmental Sciences December 202500 question series. Now let's solve question number four and the question is which of the following detectors are best suited for HLC. Now the options are mass spectrometer, thermal conductivity, absorbance and flame ionization detector. Here the answer is A and C only mass spectrometer and absorbance detectors which are best used for HLC.
But why? Because mass spectrometer provides very high sensitivity and accurate compound identification in LCMS systems. LCMS is liquid chromatography mass spectroscopy systems. UV w absorbance detectors are the most commonly used detectors in HLC because they are sensitive and reliable. But thermal conductivity detectors and flame ionization detector as their name says are mainly used in gas chromatography not HLC. Thank you so much. Remember HLC commonly uses liquid phase compatible detectors like UVBs and MS. Keep learning, keep growing and stay tuned for question number five.
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