You are taking letrozole, and Your ovulation kit said no

[00:00:00]Letrozole cycle, there's been no LH rise. What do I do? Let's go right at it. Does letrozole blunt LH? Yes or no?

[00:00:09]No. In rats, estrogen levels fell 76% and LH rose 37.8% of the control. The brain makes more, not less. That's an animal. What about humans? In 208 women, based on LH was identical in letrozole and natural cycles. The same starting line. Then why do clinics see a low LH?

[00:00:33]Number one, LH on day one was lower on the HCG trigger in 2.5 mg groups. A urine ovulation kit is a smoke alarm that only bleeps for a thick plume. A thinner, earlier wisp sets nothing off, even though the fire was real. The surge happened. Test sat at the wrong minute.

[00:00:55]And that's something which you're going to miss when you pee on letrozole cycle.

[00:00:59]Fine. But surely a low signal LH signal hurts ovulation. The Those same letrozole cycles grew more follicles and more pregnancies than natural cycles.

[00:01:09]Question again. Again in PCOS, where the LH is already high, what happens? In 835 PCOS cycles, high LH after letrozole did no harm. The normal baseline, high after letrozole group had a clear clinical pregnancy of 30.3% versus 17.3%. So what about live births?

[00:01:31]24% versus 15.2%. High LH after letrozole was a better group. So what about the follicle itself going quiet?

[00:01:41]In follicles, low estrogen, that's in cultured follicles, lowered the LH receptor gene lab level, not proven in women. But it explains a softer response without any drop in the hormone. So the surge isn't isn't masked for a from a blood test, is it? Estrogen does not chemically hide LH from an essay. It changes and how sharply the LH search fires. So, what's my final word?

[00:02:07]Letrozole lifts estrogen break, LH holds or rises, and ovulation is confirmed by a scan and a progesterone test, not by the pee stick.